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(Inclusive of all taxes) *10 Capsule(s) in a Strip * Mkt: Alkem Laboratories Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

ESOKEM L 75/40MG CAPSULE is a combination of Esomeprazole and Levosulpiride which belongs to the group of medicines called Proton-pump inhibitors and Dopamine D2 antagonists respectively. ESOKEM L 75/40MG CAPSULE is indicated for the treatment of Gastro-esophageal reflux disease (GERD) among patients who do not adequately respond to proton-pump inhibitors alone (Ex. pantoprazole, rabeprazole, esomeprazole, omeprazole).        

GERD is a chronic digestive disease in which the stomach acid frequently flows into the esophagus leading to irritation of lining of food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort.    

ESOKEM L 75/40MG CAPSULE can also be used to treat peptic ulcer caused by H. pylori infection or NSAID use. Peptic ulcers are painful sores that develop on the linings of the stomach, esophagus or intestines. Symptoms include stomach pain, flatulence, indigestion, vomiting and fatigue.   

Along treatment with ESOKEM L 75/40MG CAPSULE eat less spicy food and drink plenty of water or fluids as advised by your physician. Avoid consumption of alcohol as it could aggravate your existing disease conditions.   

Patients receiving long-term treatment with ESOKEM L 75/40MG CAPSULE should be kept on regular surveillance to rule out the risk of bone fractures (hip, wrist or spine), predominantly in patients taking corticosteroids and in patients with other recognized risk factors like osteoporosis. Before taking ESOKEM L 75/40MG CAPSULE, inform your doctor if you have any heart, kidney or liver disease as a precaution.  

ESOKEM L 75/40MG CAPSULE is not recommended for use in pregnant or breastfeeding women, including children and adolescents (aged below 18 years) due to lack of safety and effectiveness.  ESOKEM L 75/40MG CAPSULE should be used with caution in elderly patients (aged 65 years or above).

The most common side effects of taking ESOKEM L 75/40MG CAPSULE are headache, nausea, vomiting, stomach pain, diarrhea or constipation. Consult your doctor if any of the side effects worsen.

USES OF ESOKEM L 75/40MG CAPSULE

  • Treats Gastro-esophageal reflux disease (GERD) among patients who do not respond to proton-pump inhibitors (Ex. pantoprazole, rabeprazole, esomeprazole, omeprazole) alone
  • Treats peptic ulcer  

HOW ESOKEM L 75/40MG CAPSULE WORKS

ESOKEM L 75/40MG CAPSULE reduces peptic ulcers and acid reflux, where rabeprazole acts by inhibiting the secretions of stomach acid by blocking the proton pump (H+ K+ ATPase) at the secretory surface of gastric parietal cells and levosulpiride acts by blocking the dopamine D2 receptors in the gut which promotes the secretions of acetylcholine, thus facilitating gastric emptying and healing of ulcers and/or esophageal lesions.  

DIRECTIONS FOR USE

Take ESOKEM L 75/40MG CAPSULE as advised by your physician. Swallow ESOKEM L 75/40MG CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.  

SIDE EFFECTS OF ESOKEM L 75/40MG CAPSULE

COMMON

  • headache
  • nausea or vomiting
  • diarrhea, stomach pain, constipation, flatulence
  • benign polyps in stomach

UNCOMMON

  • swollen ankles and feet
  • insomnia (lack of sleep)
  • dizziness
  • pins and needles (tingling sensation in the body)
  • sleepiness
  • vertigo (spinning sensation)
  • dry mouth
  • skin rash, lumpy rash (hives) and itching
  • fracture of wrist, hip or spine

RARE

  • agitation, confusion, depression, aggression
  • blurred vision
  • changes in taste
  • bronchospasm (difficulty in breathing)
  • mouth sores
  • fungal infection (Ex. thrush)
  • hair loss
  • skin sensitivity (skin rash following sun exposure)
  • joint pain or muscle pains
  • tiredness or lack of energy
  • increased sweating
  • abnormal heart rhythm

Stop taking ESOKEM L 75/40MG CAPSULE and contact your doctor immediately if you experience the following side effects:

  • signs of severe allergic reactions (such as skin rash, sudden wheezing, swelling of the lips, tongue and throat or body, fainting or difficulty in swallowing)
  • signs of severe allergic skin reactions (such as skin redness with severe blisters or peeling, bleeding in the eyes, lips, mouth, nose or genitals associated with a high fever and joint pains)
  • signs of liver problems (such as yellowing of the skin, dark urine and tiredness)

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Stick to simple meals. Avoid eating oil rich, fried or spicy food. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom did not improve.

Diarrhoea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Flatulence:

Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. Consult your doctor if the symptom did not improve.

Constipation

Eat fiber rich foods such as fresh fruits, vegetables, cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.

WARNING & PRECAUTIONS

PREGNANCY

ESOKEM L 75/40MG CAPSULE is not recommended for use in pregnant women. Consult your doctor before taking ESOKEM L 75/40MG CAPSULE.

BREASTFEEDING

ESOKEM L 75/40MG CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking ESOKEM L 75/40MG CAPSULE.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines if you experience dizziness, drowsiness or blurred vision after taking ESOKEM L 75/40MG CAPSULE.

ALCOHOL

Avoid consumption of alcohol while taking ESOKEM L 75/40MG CAPSULE, as it could aggravate your existing disease condition.

KIDNEY

ESOKEM L 75/40MG CAPSULE is not recommended for use in patients with severe kidney disease. Consult your doctor before taking ESOKEM L 75/40MG CAPSULE.

LIVER

ESOKEM L 75/40MG CAPSULE is not recommended for use in patients with severe liver disease. Consult your doctor before taking ESOKEM L 75/40MG CAPSULE.

ALLERGY

Do not take ESOKEM L 75/40MG CAPSULE if you are allergic to Levosulpiride, Esomeprazole or other proton pump inhibitors (Ex. pantoprazole, rabeprazole, omeprazole).

HEART DISEASE

ESOKEM L 75/40MG CAPSULE should be used with caution in patients with prolongation of QTc interval (irregular electrical activity of the heart), stroke and cardiac insufficiency. Consult your doctor before taking ESOKEM L 75/40MG CAPSULE.  

OTHERS

ESOKEM L 75/40MG CAPSULE is not recommended for use if you:

  • have parkinson’s disease
  • have history of epilepsy
  • have porphyria (a rare blood disorder)
  • have breast cancer or non-cancerous tumor in breast
  • have alcohol intoxication (drinking too much alcohol in short period)
  • have certain tumors like phaeochromocytoma (tumor in adrenal glands) or pituitary prolactinoma (tumors of pituitary gland)
  • have hypokalemia (low blood potassium levels)
  • have bleeding or perforation in the stomach or intestines
  • have manic states (abnormally elevated mood)

Before taking ESOKEM L 75/40MG CAPSULE, inform your physician if you:

  • are due to have a specific blood test (Chromogranin A)
  • reduced vitamin B12 levels in body
  • osteoporosis

Use in pediatrics:

ESOKEM L 75/40MG CAPSULE is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety and effectiveness. Consult your child’s doctor for advice.

Use in geriatrics:

ESOKEM L 75/40MG CAPSULE should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before taking ESOKEM L 75/40MG CAPSULE.

INTERACTIONS

A. Drug-Drug interactions:

Before taking ESOKEM L 75/40MG CAPSULE inform to your doctor, if you are taking any of these medicines:

  • medicines used to treat HIV infection (Ex. nelfinavir, atazanavir)
  • medicines used to treat fungal infections (Ex. ketoconazole, itraconazole or voriconazole)
  • medicines used to treat depression (Ex. citalopram, imipramine, clomipramine, rasagiline, selegiline, phenelzine, or St. John’s wort)
  • anticholinergics (used to reduce gastrointestinal movements) such as atropine, biperiden or hyoscine butylbromide
  • narcotic analgesics (used to provide pain relief) Ex. morphine, pethidine, fentanyl
  • medicines that can make you feel sleepy or drowsy such as sedatives or hypnotics (Ex. phenobarbital) or tranquilizers (Ex. diazepam, clonazepam, lorazepam)
  • clopidogrel (an antiplatelet medicine used to prevent blood clots)
  • erlotinib (used to treat cancer)
  • phenytoin (used to treat epilepsy)
  • medicines used for blood thinning (Ex. warfarin)
  • cilostazol (a medicine used to treat intermittent claudication (pain in legs))
  • cisapride (used to treat heartburn or indigestion)
  • digoxin (used to treat abnormal heart rhythm)
  • methotrexate (a medicine used to treat cancer or other auto-immune disease)
  • tacrolimus (used to suppress immune function and prevent graft rejection)
  • rifampicin (used to treat tuberculosis)
  • diuretics (used to reduce blood pressure by increasing urine output) Ex. furosemide, hydrochlorothiazide

B. Drug-Food interaction:

ESOKEM L 75/40MG CAPSULE can be taken with food or on an empty stomach. Try to take this medicine at least one hour before meals to maximize the efficacy. However, consult your doctor before taking ESOKEM L 75/40MG CAPSULE.

Overdosage:

If you or anyone else accidentally take too much of ESOKEM L 75/40MG CAPSULE, contact your doctor immediately or go to a hospital straight away.

SYNOPSIS

Drug :  

Esomeprazole, Levosulpiride

Pharmacological Category :  

Proton pump inhibitors, Dopamine D2 antagonists

Therapeutic Indication :  

Gastro-esophageal reflux disease (GERD), Peptic ulcer

Dosage Forms :  

Tablet, Capsule

MORE INFORMATION

  • Keep ESOKEM L 75/40MG CAPSULE out of reach of children
  • Store at room temperature

FAQs ABOUT ESOKEM L 75/40MG CAPSULE

Can ESOKEM L 75/40MG CAPSULE be used in children?

ESOKEM L 75/40MG CAPSULE is generally not recommended for use in children and adolescents (aged below 18 years) due to lack of safety and effectiveness. Kindly consult your child’s doctor for advice.      

Can ESOKEM L 75/40MG CAPSULE be used during pregnancy?

No, ESOKEM L 75/40MG CAPSULE is generally not recommended for use in pregnant women. If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking ESOKEM L 75/40MG CAPSULE.   

Can ESOKEM L 75/40MG CAPSULE cause depression?

Yes, ESOKEM L 75/40MG CAPSULE can rarely cause depression in some individuals. If you experience any signs of depression such as feeling extremely sad, solitary attitude, lack of social connectivity, please contact your doctor immediately.   

Can ESOKEM L 75/40MG CAPSULE be taken for long term?

ESOKEM L 75/40MG CAPSULE can be taken as a long-term therapy for gastrointestinal disorders. However, consult your doctor before taking ESOKEM L 75/40MG CAPSULE. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and health condition. Do not stop taking ESOKEM L 75/40MG CAPSULE abruptly or take for a longer period than prescribed without consulting your doctor.  

Can ESOKEM L 75/40MG CAPSULE cause black stools?

Yes, ESOKEM L 75/40MG CAPSULE can rarely cause black stools or blood-stained stools in some individuals. If you experience black stools or blood-stained stools with or without stomach pain or indigestion, stop taking ESOKEM L 75/40MG CAPSULE and consult your doctor immediately.

Is ESOKEM L 75/40MG CAPSULE safe to use in patients with heart problems?

ESOKEM L 75/40MG CAPSULE should be used with caution in patients with prolongation of QTc interval (irregular electrical activity of the heart), stroke and cardiac insufficiency. Consult your doctor before taking ESOKEM L 75/40MG CAPSULE.  

REFERENCES

1. KD. Tripathi. Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page – 653.

2. Keith A. Sharkey and John L. Wallace. Treatment of disorders of bowel motility and water flux; Antiemetics; Agents used in biliary and pancreatic disease and Pharmacotherapy of gastric acidity, peptic ulcer, and gastroesophageal reflux disease. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1326 & 1311-1313.

3. Gerald G. Briggs and Roger K. Freeman. E. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 1427 & -2775.

4. Evangelos Kalaitzakis and Einar Bjornsson. A review of esomeprazole in the treatment of gastroesophageal reflux disease (GERD). NCBI; PMC US National Library of Medicine, National Institute of Health. August 2007. [Accessed on 29th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374928/

5. Caroline M den Hoed, Ernst J Kuipers. Esomeprazole for the treatment of peptic ulcer bleeding. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. December 2010. [Accessed on 29th October 2022] https://pubmed.ncbi.nlm.nih.gov/21108587/

6. Syed Ibrahim Hassan, Syed Mohd Akbar Hassan. Comparison of Safety and Efficacy of Levosulpiride and Itopride in Treatment of Gastroesophageal Reflux Disease. Journal of Evidence based medicine and healthcare. January 2017. [Accessed on 29th October 2022] https://jebmh.com/latest_articles/95552

7. R Lozano, MG Peralta Concha, A Montealegre, L de Leon, J Ortiz Villalba, HO Lee Esteban, M Cromeyer, JA Rivas García, A Brossa, G Lluberes, E Izquierdo Sandi and H Burgos Quiros. Effectiveness and safety of levosulpiride in the treatment of dysmotility-like functional dyspepsia. NCBI; PMC US National Library of Medicine, National Institute of Health. March 2007. [Accessed on 29th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936295/

8. Chi-Wook Song, Hoon-Jae Chun, Chang-Duck Kim, Ho-Sang Ryu, Jae-Gol Choe, and Jin-Hai Hyun. Effects of Levosulpiride in Patients with Functional Dyspepsia Accompanied by Delayed Gastric Emptying. NCBI; PMC US National Library of Medicine, National Institute of Health. February 1998. [Accessed on 29th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531935/

9. Torrent Pharmaceuticals Ltd. Nexpro L Esomeprazole DR and Levosulpiride ER Capsules. Torrentian.com. [Revised in June 2020]. [Accessed on 29th October 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2500.pdf

10. Cipla Ltd. Esomac-L Capsules (Esomeprazole magnesium + Levosulpiride). Ciplamed.com. [Revised in July 2020]. [Accessed on 29th October 2022] https://www.ciplamed.com/content/esomac-l-capsules

11. Soigner Pharma. Esomeprazole & Levosulpiride Capsules. [Accessed on 29th October 2022] https://www.soignerpharma.com/product/esperam-ls/

12. Alniche Life Science Pvt Ltd. Gastroenterology. [Accessed on 29th October 2022] https://www.alniche.com/product/esobiz-dsr-l/

13. Steris Healthcare Pvt Ltd. Esomeprazole+ Levosulpiride. [Accessed on 29th October 2022] https://www.sterisindia.com/latest-update/esomeprazole-levosu/1111

14. Aelida Healthcare. Esomeprazole 40 Mg +levosulpiride 75 Mg Sustain Release Caps. [Accessed on 29th October 2022] http://www.aelidahealthcare.in/esomeprazole-40-mg-levosulpiride-75-mg-sustain-release-caps-6423328.html

15. Mits Healthcare Private Limited. Esomeprazole sodium and levosulpiride capsule. [Accessed on 29th October 2022] https://www.mitshealthcare.in/product/esomeprazole-sodium-and-levosulpiride-capsule-manufacturers-and-suppliers

16. Vibcare Pharma Pvt. Ltd. Esovib L. [Accessed on 29th October 2022] https://vibcare.co.in/esomeprazole-levosulpiride/#!/INDICATION

USEFUL DIAGNOSTIC TESTS

  • Helicobacter Pylori IgA
  • Helicobacter Pylori IgG

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    17.5 g
    Ingredient
    LEVOSULPIRIDE 75MG+ESOMEPRAZOLE 40MG
    Hsn Code
    30049039
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Esokem L 75/40mg Capsule 10'S

Esokem L 75/40mg Capsule 10'S Mkt: Alkem Laboratories Ltd

M.R.P.: Rs.248.60
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