INTRODUCTION
ERYPRO PREFIL 2000IU (PFS) contains Erythropoietin alfa which belongs to a group of medicines called Erythropoiesis-Stimulating agent (ESA). It is used to treat symptomatic anaemia caused by kidney disease (in children on haemodialysis, in adults on haemodialysis or peritoneal dialysis and in severely anaemic adults not yet undergoing dialysis), anaemia in adults receiving chemotherapy for solid tumors. It is also used to treat moderately anaemic adults who donate their blood before surgery, in patients about to have major orthopaedic surgery and anaemia in patients with a bone marrow disorder that causes a severe disruption in the creation of blood cells (myelodysplastic syndromes).
Erythropoietin alfa (epoetin alfa) is a protein that stimulates the bone marrow to produce more red blood cells which carry haemoglobin (a substance that transports oxygen).
This medicine will be administered by your doctor or nurse by intravenous or subcutaneous route. Before receiving ERYPRO PREFIL 2000IU (PFS), tell your physician if you have high blood pressure, blood clotting diseases or problems related to liver, kidney and heart. Pregnant and breastfeeding women are recommended to consult the doctor before receiving this medicine. The common side effects are diarrhea, vomiting, headache, redness, burning and pain at the site of injection.
USES OF ERYPRO PREFIL 2000IU (PFS)
Treats,
- anaemia due to kidney disease
- anaemia in patients receiving chemotherapy for solid tumours
HOW ERYPRO PREFIL 2000IU (PFS) WORKS
ERYPRO PREFIL 2000IU (PFS) belongs to erythropoiesis-stimulating agents which works by causing the bone marrow (soft tissue inside the bones where blood is made) to make more red blood cells.
DIRECTIONS FOR USE
ERYPRO PREFIL 2000IU (PFS) will be administered intravenously or subcutaneously (under the skin) by your doctor or nurse.
SIDE EFFECTS OF ERYPRO PREFIL 2000IU (PFS)
SERIOUS
- serious skin rashes
COMMON
- diarrhea
- feeling sick in stomach
- vomiting
- fever
- stuffy nose and sore throat (respiratory tract congestion)
- increase in blood pressure
- headache
- blood clots
- feeling confused or having fits
- chest pain, breathlessness, painful swelling and redness (leg)
- cough
- bone or muscle pain
- flu-like symptoms
- redness, burning and pain (injection site)
- arm or leg pain
RARE
- unusual tiredness, feeling dizzy, breathlessness (Pure red cell Aplasia)
- increase in levels of small blood cells
- pain, dark coloured urine or increased sensitivity of the skin to sunlight (porphyria)
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and drink plenty of fluids. Apply a wet or cold cloth on forehead and rest in a quiet, comfortable and dark room.
Diarrhoea:
Drink plenty of fluids to avoid dehydration. ORS can also be used to prevent dehydration.
Vomiting:
Drink clear or ice-cold drinks. Eat light and bland foods. Avoid sweets.
WARNING & PRECAUTIONS
PREGNANCY
Pregnant women, consult your doctor before using ERYPRO PREFIL 2000IU (PFS).
BREASTFEEDING
It is not known whether ERYPRO PREFIL 2000IU (PFS) is excreted in human milk. Consult your doctor for advice.
KIDNEY
ERYPRO PREFIL 2000IU (PFS) should be used with caution in patients with kidney disease. Consult your doctor for advice.
LIVER
ERYPRO PREFIL 2000IU (PFS) should be used with caution in patients with liver disease. Consult your doctor for advice.
ALLERGY
Tell your doctor if you are allergic (hypersensitive) to Erythropoietin alfa.
LUNGS
ERYPRO PREFIL 2000IU (PFS) should be used with caution in patients with lung disease. Consult your doctor for advice.
HEART DISEASE
ERYPRO PREFIL 2000IU (PFS) is not recommended in patients with recent episodes of heart attack or stroke, severe heart disease, severe disorders of the veins and arteries. Consult your doctor for advice.
OTHERS
Tell your doctor before taking this medicine if you,
- have been diagnosed with Pure Red Cell Aplasia (bone marrow cannot produce enough red blood cells)
- have high blood pressure
- cannot have transfusions with own blood
- are going to have major elective orthopaedic surgery
- have blood clot
- are overweight
- have diabetes
- have epileptic seizures or fits
- have anaemia from other causes
- have porphyria (a rare blood disorder)
- have cancer
- have serious skin reactions
Use in pediatrics:
- Your doctor will administer the right dose depends on your child’s age and body weight.
Use in geriatrics:
- Dose adjustments may be required for patients with kidney disease, consult your doctor for advice.
INTERACTIONS
A. Drug - Drug interactions:
Tell the doctor about all the medications including prescription, non-prescription and herbal supplements.
- cyclosporin (used after kidney transplants)
- iron supplements and other blood stimulants
Overdosage:
- Tell the doctor or nurse immediately if you think too much ERYPRO PREFIL 2000IU (PFS) has been injected.
SYNOPSIS
| Drug | : | Erythropoietin alfa (epoetin alfa) |
| Pharmacological Category | : | Erythropoiesis-Stimulating Agent (ESA) |
| Therapeutic Indication | : | Anemia due to chemotherapy in patients with cancer, chronic kidney disease |
| Dosage Forms | : | Injection |
MORE INFORMATION
- Keep out of reach of children
- Store between 2-8°C
FAQs ABOUT ERYPRO PREFIL 2000IU (PFS)
What is ERYPRO PREFIL 2000IU (PFS) used for?
ERYPRO PREFIL 2000IU (PFS) helps your body make more red blood cells.
How do I know if ERYPRO PREFIL 2000IU (PFS) is working?
Your doctor will test the blood regularly, at least weekly at the beginning of your treatment.
What should I check before taking ERYPRO PREFIL 2000IU (PFS)?
You will be monitored regularly by your doctor while you are taking this medicine.
Can ERYPRO PREFIL 2000IU (PFS) affect blood pressure?
Yes. During initial therapy, blood pressure should be monitored and those who have high blood pressure should take appropriate measures to control blood pressure.
REFERENCES
1. KD Tripathi MD. Haematinics and Erythropoietin. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 611.
2. Kaushansky K, Kipps TJ. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page -1071-1072.
3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 479-481.
4. Janssen-Cilag Ltd. Electronic Medicines Compendium (EMC); [Revised on March, 2021] [Accessed on Sep 25, 2021] https://www.medicines.org.uk/emc/files/pil.3442.pdf
5. Janssen Products, LP. Amgen Inc. [Revised on May, 2012] [Accessed on Sep 25, 2021] https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/PROCRIT-pi.pdf
6. Ortho Biotech Products, L.P. Amgen Inc. U.S. Food & Drug Administration; [Revised on Aug, 2008] [Accessed on Sep 25, 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/103234s5196pi.pdf
7. Drugs.com. Epoetin Alfa. [Revised on June 02, 2020] [Accessed on Sep 25, 2021] https://www.drugs.com/ppa/epoetin-alfa.html
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
- Peripheral Smear Examination
PRODUCT DETAILS
ALTERNATE BRANDS View All
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.