Erlonat 100mg Tablet 30'S

Cancer/Oncology Rx required

Best Price* ₹ 3,174.49 MRP ₹ 4,348.61 GET 27% off
(Inclusive of all taxes) *30 Tablet(s) in a Bottle * Mkt: Natco Pharma Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

ERLONAT 100MG TABLET contains Erlotinib which belongs to the group of medicines called Kinase inhibitors. It is used in adults to treat non-small cell lung cancer at an advanced stage, as initial therapy (or as therapy if disease remains largely unchanged after initial chemotherapy, provided your cancer cells have specific EGFR mutations).

It is also used if previous chemotherapy has not helped to stop the disease and to treat cancer of the pancreas at a metastatic stage in combination with gemcitabine. Cancer can be defined as body cells beginning to grow out of control. Cells in any part of the body can become cancer cells and can spread to other areas of the body. Your doctor may perform certain blood tests prior to the treatment.

Avoid smoking during the treatment of ERLONAT 100MG TABLET, as it decreases the effect of the medicine. ERLONAT 100MG TABLET is not recommended for use if you have severe liver or kidney disease. Before taking ERLONAT 100MG TABLET inform your doctor if you have diarrhea, glucuronidation disorder like Gilbert’s syndrome, history of peptic ulcers or diverticular disease, you use contact lenses, or have a history of eye problems (severe dry eyes, inflammation or ulcers of the cornea).

ERLONAT 100MG TABLET is generally not recommended for use in pregnant and breastfeeding women unless considered clearly necessary, therefore consult your doctor before taking it. ERLONAT 100MG TABLET is not recommended for use in children and adolescents below 18 years of age. The most common side effects of taking ERLONAT 100MG TABLET are rash, infection, loss of appetite, decreased weight, or depression. Contact your doctor if any of the symptoms worsen.

USES OF ERLONAT 100MG TABLET

Treats:

  • non-small cell lung cancer at an advanced stage
  • initial cancer stage (or as therapy if disease remains largely unchanged after initial chemotherapy)
  • pancreatic cancer at a metastatic stage in combination with gemcitabine

HOW ERLONAT 100MG TABLET WORKS

ERLONAT 100MG TABLET binds to the intracellular portion (tyrosine kinase) of the epidermal growth factor receptor (EGFR) and inhibits its activity. EGFR is expressed on the surface of both normal as well as cancer cells. Inhibition of EGFR and its signaling significantly decreases tumor multiplication and survival, resulting in cell death.

DIRECTIONS FOR USE

Take ERLONAT 100MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Do not take medicine with food. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.

SIDE EFFECTS OF ERLONAT 100MG TABLET

COMMON

  • rash which may occur or worsen in sun-exposed areas
  • infection
  • loss of appetite, decreased weight
  • depression
  • headache
  • change in skin sensation or numbness in the extremities
  • difficulty in breathing, cough
  • nausea
  • mouth irritation
  • stomach pain, indigestion, and flatulence
  • itching, dry skin
  • loss of hair
  • tiredness, fever, rigor
  • bleeding from the nose, stomach, or the intestines
  • inflammatory reactions around the fingernail
  • infection of hair follicles
  • acne
  • cracked skin (skin fissures)
  • reduced kidney function

UNCOMMON

  • eyelash and eyebrow changes
  • excess hair in the body and face of a male distribution pattern
  • brittle and loose nails

RARE

  • palmar plantar erythrodysaesthesia syndrome (flushed or painful palms or soles)

Stop taking ERLONAT 100MG TABLET and contact your doctor immediately if you experience any of the following side effects:

  • persistent and severe diarrhea and vomiting
  • eye irritation due to conjunctivitis/keratoconjunctivitis or keratitis
  • interstitial lung disease (sudden difficulty breathing associated with cough or fever)
  • gastrointestinal perforations (severe pain in the abdomen)
  • acute or worsening redness and pain in the eye increased water in the eye, blurred vision, and/or sensitivity to light
  • blistering or peeling of skin
  • inflammation of the liver ( feeling of being unwell, with or without jaundice (yellowing of the skin and eyes), dark urine, nausea, vomiting and abdominal pain)

HOW TO MANAGE SIDE EFFECTS

Nausea:

Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.

Headache:

Take some rest, in a quiet place and avoid using mobile phones and other electronic devices for a while. Drink water as inadequate hydration may worsen your headache. If symptoms persist, contact your doctor.

Stomach pain:

Rest and relax. Try to have smaller meals but take them frequently. Keep a heat pad on your stomach. Do not self-treat and contact your doctor if the symptom did not improve.

Flatulence:

Eat smaller and more frequent meals. Eat and drink slowly and exercise regularly. If the symptoms do not improve, contact your doctor.

Loss of appetite:

Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack which is rich in calories and protein, such as dried fruit and nuts.

WARNING & PRECAUTIONS

PREGNANCY

There is no adequate data on the use of ERLONAT 100MG TABLET in pregnant women. If you become pregnant during the treatment immediately inform your doctor who will decide if the treatment should be continued.

Use adequate contraception during treatment, and for at least 2 weeks after taking the last medicine. Consult your doctor before taking ERLONAT 100MG TABLET.

BREASTFEEDING

ERLONAT 100MG TABLET is not recommended for use in breastfeeding women and for at least 2 weeks after taking the last medicine. Consult your doctor before taking ERLONAT 100MG TABLET.

DRIVING AND USING MACHINES

ERLONAT 100MG TABLET is unlikely to affect your ability to drive or use machines.

KIDNEY

ERLONAT 100MG TABLET is generally not recommended to use in patients with severe kidney disease. Consult your doctor before taking ERLONAT 100MG TABLET.

LIVER

ERLONAT 100MG TABLET is generally not recommended to use in patients with severe liver disease. Consult your doctor before taking ERLONAT 100MG TABLET.

ALLERGY

Do not take ERLONAT 100MG TABLET if you are allergic to Erlotinib or any of the other ingredients of the medicines.

OTHERS

Before taking ERLONAT 100MG TABLET, inform your doctor if you have:

  • contact lenses
  • history of eye problems such as severe dry eyes, inflammation or ulcers of the front part of the eye (cornea)
  • diarrhea
  • history of peptic ulceration or diverticular disease
  • glucuronidation disorder like Gilbert’s syndrome

Use in pediatrics:

ERLONAT 100MG TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking ERLONAT 100MG TABLET.

INTERACTIONS

A. Drug-Drug interactions:

Before taking ERLONAT 100MG TABLET, inform your doctor if you are taking any of the following medicine:

  • ketoconazole (to treat fungal infections)
  • erythromycin, clarithromycin, and ciprofloxacin (antibacterial agents)
  • protease inhibitors like atazanavir, idinavir (to treat HIV)
  • warfarin (to prevent blood clotting)
  • statins (Ex. atorvastatin, rosuvastatin, simvastatin) to lower blood cholesterol
  • phenytoin, carbamazepine (treats epilepsy or fits)
  • omeprazole, ranitidine (reduces stomach acid)
  • rifampicin (treats tuberculosis)
  • St. John’s Wort (treats depression)
  • barbiturates (used to treat seizures)

Overdosage:

If you or anyone else accidentally takes too much ERLONAT 100MG TABLET, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

Drug :   Erlotinib
Pharmacological Category :   Kinase inhibitors
Therapeutic Indication :   Non-small cell lung cancer, initial cancer therapy and pancreatic cancer
Dosage Forms :   Tablet

MORE INFORMATION

  • Keep ERLONAT 100MG TABLET out of reach of children
  • Store at room temperature

FAQs ABOUT ERLONAT 100MG TABLET

What is ERLONAT 100MG TABLET used for?

ERLONAT 100MG TABLET is used in adults to treat non-small cell lung cancer at an advanced stage, as initial therapy (or as therapy if disease remains largely unchanged after initial chemotherapy, provided your cancer cells have specific EGFR mutations), if previous chemotherapy has not helped to stop the disease and to treat cancer of the pancreas at a metastatic stage in combination with gemcitabine.

What is the mechanism of action of ERLONAT 100MG TABLET?

ERLONAT 100MG TABLET binds to the intracellular portion (tyrosine kinase) of the epidermal growth factor receptor (EGFR) and inhibits its activity. EGFR is expressed on the surface of both normal as well as cancer cells. Inhibition of EGFR and it’s signaling significantly decreases tumor multiplication and survival, resulting in cell death.

Can ERLONAT 100MG TABLET be used in pregnant women?

There is no adequate data on the use of ERLONAT 100MG TABLET in pregnant women. If you become pregnant during the treatment immediately inform your doctor who will decide if the treatment should be continued.

Can ERLONAT 100MG TABLET be taken along with Statins?

If you are taking statins (medicines to lower your blood cholesterol), ERLONAT 100MG TABLET may increase the risk of statin related muscle problems, which on rare occasions can lead to serious muscle breakdown (rhabdomyolysis) resulting in kidney damage, talk to your doctor before taking this medicine.

Can ERLONAT 100MG TABLET be used in children?

ERLONAT 100MG TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor for more information on this medicine before taking it.

REFERENCES

1. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018 Page – 863-886.

2. Jose Ramon Gonzalez-Porras and Jose Maria Bastida. Eltrombopag in immune thrombocytopenia: efficacy review and update on drug safety. National Library of Medicine, National Center for Biotechnology information. Pubmed Central. June 2018. [Accessed on 13th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971401/

3. Marco Dionisi, Sara Cairoli, Raffaele Simeoli, Francesca De Gennaro, Valeria Paganelli, Roberto Carta, Francesca Rossi, Carlo Dionisi-Vici, Giuseppe Palumbo and Bianca Maria Goffredo. Pharmacokinetic Evaluation of Eltrombopag in ITP Pediatric Patients. Journal of frontiers in pharmacology. December 2021 [Accessed on 13th May 2022] https://www.frontiersin.org/articles/10.3389/fphar.2021.772873/full

4. Roche Products Limited. Electronic Medicines Compendium (EMC). [Revised in November 2022]. [Accessed on 13th May 2022] https://www.medicines.org.uk/emc/files/pil.8844.pdf

5. OSI Pharmaceuticals Inc. U.S Food and Drug Administration. [Revised in October 2016] [Accessed on 13th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021743s025lbl.pdf

USEFUL DIAGNOSTIC TESTS

  • Blood test

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    40 g
    Ingredient
    ERLOTINIB 100MG
    Hsn Code
    30049049
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Erlonat 100mg Tablet 30'S

Erlonat 100mg Tablet 30'S Mkt: Natco Pharma Ltd

Rs.3,174.49 27% off M.R.P.: Rs.4,348.61
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