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Drug Information

What is Eplerenone used for?

Eplerenone is prescribed to treat high blood pressure (hypertension), which, if left untreated, can lead to stroke, heart failure or kidney failure. Besides hypertension, this drug is also prescribed to treat congestive heart failure following a heart attack. This medicine may also be used to treat other conditions as determined by your doctor.

How to take Eplerenone?

The dosage of Eplerenone prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label. The following dosage information includes the common dose of Eplerenone. If your dose is different, do not follow the dosage described below unless your physician has approved.

The recommended dosage of Eplerenone is usually once or twice daily. This medication can be taken by mouth with or without food. It must be taken regularly and should be continued despite feeling well. The complete effect of this drug can be felt after four weeks of its consumption.

If your physician has instructed or directed you to take Eplerenone medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, instead skip the missed dose and go back to your regular dosing schedule. Do not double the doses unless otherwise directed.

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately. Some of the overdose symptoms of Eplerenone include severe muscle weakness, severe dizziness and irregular heartbeat.

What are the drugs that interact with Eplerenone?

  • Amiloride
  • Captopril
  • Clarithromycin
  • Enalapril
  • Erythromycin
  • Fluconazole
  • Ibuprofen
  • Indomethacin
  • Itraconazole
  • Ketoconazole
  • Lithium
  • Losartan
  • Naproxen
  • Nefazodone
  • Nelfinavir
  • Ritonavir
  • Saquinavir
  • Spironolactone
  • St. John's wort
  • Triamterene
  • Troleandomycin
  • Valsartan
  • Verapamil

It may be noted that drugs other than those listed above may also interact with Eplerenone.

Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Eplerenone, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions.

Eplerenone can interact with certain protease inhibitors, certain macrolide antibiotics, potassium supplements, and protease inhibitors.

Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. Make sure to inform your doctor of any medical conditions you may have, or any family history of medical problems. Do not start or stop using any medicine without consulting your doctor.

What are the side effects of Eplerenone?

Like other medicines, Eplerenone can cause some side effects. If they do occur, the side effects of Eplerenone are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.

It is pertinent to note that side effects of Eplerenone cannot be anticipated. If any side effects of Eplerenone develop or change in intensity, the doctor should be informed as soon as possible.

Eplerenone can cause side effects such as :

  • Headache
  • Diarrhea
  • Stomach pain
  • Dizziness
  • Nausea
  • Cough, or flu-like symptoms

Some of the uncommon side effects of eplerenone include:

  • Itching
  • Chronic muscle weakness
  • Severe dizziness
  • Changes in mood

This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Eplerenone.

What are the questions to ask your doctor before taking Eplerenone?

Is it possible for me to take Eplerenone with other drugs?
Should certain beverages, foods and other products be avoided when I take Eplerenone?
What are the possible drug interactions of Eplerenone?
How will Eplerenone work in my body?
How should Eplerenone be taken?
How to reduce the risk of Eplerenone drug interactions and side effects?

What should you tell your doctor before taking Eplerenone?

Before taking Eplerenone, it is important to inform doctor if you have high potassium blood levels, low sodium levels, diabetes, heart disease, lever problems or severe kidney disease. Also, it is important to discuss with your doctor about your excessive intake of salt substitutes or potassium-containing foods such as bananas. When using this drug, caution should be exercised while driving or handling machinery as it may cause dizziness.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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