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INTRODUCTION
EPIMAC PLUS TABLET is a combination of Eperisone and Paracetamol which belongs to the group of medicines called Muscle relaxants and Analgesics respectively. It is used to treat pain due to muscle spasm.
Avoid consumption of alcohol while taking this medicine as it may severely damage the liver. EPIMAC PLUS TABLET should be used with caution in patients with asthma, liver disease or disorder and kidney disease.
EPIMAC PLUS TABLET should be used with caution in pregnant women unless advised by the doctor and it is not recommended for use in breastfeeding women. EPIMAC PLUS TABLET is not recommended for use in children due to lack of safety data and it should be used with caution in elderly patients (aged 65 years and above).
The most common side effects of taking EPIMAC PLUS TABLET are nausea, vomiting, stomach discomfort, abdominal pain, general discomfort and constipation. Consult your doctor if any of the side effects worsen over the time.
USES OF EPIMAC PLUS TABLET
- Treats pain due to muscle spasm
HOW EPIMAC PLUS TABLET WORKS
EPIMAC PLUS TABLET helps to treat pain due to muscle spasm, where eperisone works by acting on the centres in the brain and spinal cord. It also dilates vascular smooth muscles improving blood flow and relieves muscle spasm. Paracetamol works by increasing the pain threshold by inhibiting COX-1 and COX-2 enzymes.
DIRECTIONS FOR USE
Take EPIMAC PLUS TABLET as advised by your physician. Swallow EPIMAC PLUS TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking EPIMAC PLUS TABLET without informing your doctor.
SIDE EFFECTS OF EPIMAC PLUS TABLET
COMMON
- nausea, vomiting
- loss of appetite, gastric discomfort
- abdominal pain
- diarrhea, constipation
- light-headedness, drowsiness
- lack of energy
- general discomfort
- rash, itching
- erythema multiforme exudativum (red and raised rash)
RARE
- depression, confusion, hallucinations
- tremor, headache
- disturbed vision
- oedema (abnormal accumulation of fluid under the skin)
- bleeding from stomach or intestines
- dizziness, fever
Stop taking EPIMAC PLUS TABLET and contact your physician immediately if you experience any of the following side effects:
- severe allergic reactions (signs include swelling of the face, lips, tongue, neck or throat causing difficulty in breathing)
- anaphylactoid symptoms (such as itchiness, edema (such as facial), respiratory distress)
- steven-johnson syndrome, toxic epidermal necrosis (signs include fever, erythema, bloodshot eyes)
HOW TO MANAGE SIDE EFFECTS
Constipation
Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals and drink plenty of water. Exercise regularly (such as daily walk). If this does not help, consult your doctor for receiving alternate treatment for constipation.
Diarrhea
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Do not take any medicine on your own for treating diarrhoea. Consult your doctor if the symptom does not improve.
Headache
Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the forehead if necessary. Do not consume alcohol. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Take this medicine with or immediately after food. Stick to simple meals. Avoid eating oily, fried and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom does not improve.
Stomach Pain
Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, consult your doctor.
WARNING & PRECAUTIONS
PREGNANCY
Use with CautionEPIMAC PLUS TABLET should be used with caution during pregnancy unless considered clearly necessary. Consult your doctor before taking EPIMAC PLUS TABLET.
BREASTFEEDING
ContraindicatedEPIMAC PLUS TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking EPIMAC PLUS TABLET.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you feel weakness, sleepiness, light-headedness after taking EPIMAC PLUS TABLET.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking EPIMAC PLUS TABLET as it may severely damage the liver.
KIDNEY
Use with CautionEPIMAC PLUS TABLET should be used with caution in patients with kidney disease. Consult your doctor before taking EPIMAC PLUS TABLET.
LIVER
Use with CautionEPIMAC PLUS TABLET should be used with caution in patients with liver disorder or disease (including Gilbert’s syndrome or hepatitis). Consult your doctor before taking EPIMAC PLUS TABLET.
ALLERGY
ContraindicatedDo not take EPIMAC PLUS TABLET if you are allergic to Eperisone, Paracetamol or other ingredients of this medicine.
LUNGS
Use with CautionEPIMAC PLUS TABLET should be used with caution in patients with asthma. Consult your doctor before taking EPIMAC PLUS TABLET.
OTHERS
Before taking EPIMAC PLUS TABLET, inform your doctor if you:
- are dehydrated or have impaired nutritional state (caused by alcohol abuse or wrong nutrition)
- haemolytic anaemia (abnormal breakdown of red blood cells)
- deficiency of glucose- 6-phosphatedehydrogenase enzyme
- serious infection such as blood poisoning
Use in Paediatrics:
EPIMAC PLUS TABLET is not recommended for use in children due to lack of safety data. Consult your child’s doctor for advice.
Use in geriatrics:
EPIMAC PLUS TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions:
Before taking EPIMAC PLUS TABLET inform your doctor if you are taking any of the following medicines:
- methocarbamol (used to treat muscle spasm)
- probenecid (used to treat gout)
- salicylamide (used to treat fever and pain)
- lamotrigine, phenytoin (used to treat epilepsy)
- barbiturates such as pentobarbital, phenobarbital or carbamazepine (medicines used to treat mental disorders and epilepsy)
- chloramphenicol, rifampicin, isoniazid (medicines used to treat bacterial infections)
- St. john’s wort (used to treat depression)
- medicines that delay emptying of stomach (Ex. dicyclomine)
- anticoagulants Ex. warfarin (medicines used to prevent or treat blood clots)
- medicines used for nausea and vomiting (Ex. metoclopramide, domperidone)
- cholestyramine (medicines used to lower high cholesterol levels)
- imatinib (medicine used to treat leukaemia and some stomach tumours)
Overdosage:
If you or anyone else accidentally take too much of EPIMAC PLUS TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of EPIMAC PLUS TABLET inlcudes nausea, vomiting, loss of appetite, paleness, stomach pain and liver damage.
SYNOPSIS
| Drug | : | Eperisone, Paracetamol |
| Pharmacological Category | : | Muscle relaxant, Analgesics |
| Therapeutic Indication | : | Pain due to muscle spasm |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep EPIMAC PLUS TABLET out of reach of children
- Store at room temperature
FAQs ABOUT EPIMAC PLUS TABLET
Q: What to do If I forget to take a dose of EPIMAC PLUS TABLET?
A: You should take EPIMAC PLUS TABLET immediately when you remember. If it is time for the next dose skip the missed dose and follow the regular dose schedule. Do not double the dose to match up the missed dose.
Q: How does EPIMAC PLUS TABLET work?
A: EPIMAC PLUS TABLET helps to treat pain due to muscle spasm, where eperisone works by acting on the centres in the brain and spinal cord. It also dilates vascular smooth muscles improving blood flow and relieves muscle spasm. Paracetamol works by increasing the pain threshold by inhibiting COX-1 and COX-2 enzymes.
Q: Is EPIMAC PLUS TABLET safe to use in patients with liver problems?
A: EPIMAC PLUS TABLET should be used with caution in patients with liver disorder or disease (including Gilbert’s syndrome or hepatitis). Consult your doctor for advice before taking it.
Q: What are the common side effects of EPIMAC PLUS TABLET?
A: The common side effects of taking EPIMAC PLUS TABLET are nausea, vomiting, loss of appetite, gastric discomfort, abdominal pain, diarrhea, constipation, light-headedness, drowsiness, general discomfort, lack of energy, rash and itching. Consult your doctor if any of the side effects worsen over the time.
Q: Does EPIMAC PLUS TABLET cause constipation?
A: Yes, this medicine may cause constipation in some individuals. To manage this effect, try to eat more high-fiber foods such as fresh fruit, vegetables, cereals and drink plenty of water. Exercise regularly (such as daily walk). If this does not help, consult your doctor for receiving alternate treatment for constipation.
REFERENCES
1. K.D. Tripathi. NSAIDs and Antipyretic- Analgesics. Essentials of medical pharmacology. Seventh edition. 2013. Page - 206.
2. P. Cabitza, P. Randelli. Uses of Eperisone. European Review for Medical and Pharmacological Sciences. December 2008. [Accessed on 15th June 2022] http://europeanreview.org/wp/wp-content/uploads/502.pdf
3. Eperisone. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem. 2004. [Accessed on 15th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/eperisone
4. Accord, Barnstaple. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 15th June 2022] https://www.medicines.org.uk/emc/files/pil.5916.pdf
5. Balkan Pharma. Health Products Regulatory Authority (HPRA). [Revised in June 2019] [Accessed on 15th June 2022] https://www.hpra.ie/img/uploaded/swedocuments/2b04cfdb-8571-4543-a4c9-b1380e0a92c3.pdf
6. Eisai Co., Ltd. Myonal Tablet (Eperisone). [Revised in July 2009] [Accessed on 15th June 2022] http://www.shijiebiaopin.net/upload/product/201082521391314.pdf
7. Taj Pharmaceuticals. Eperisone and Paracetamol Tablet. [Accessed on 15th June 2022] https://tajpharma.in/portfolio-item/eperisone-hdrochloride-paracetamol-50mg325mg-tablets-taj-pharma/
8. Steris Healthcare Pvt Ltd. Epstate Plus Tablet (Eperisone and Paracetamol). [Accessed on 15th June 2022] https://www.sterisindia.com/latest-update/eperisone-hydrochlor/7176
9. Towa Pharmaceutical Co., Ltd. Eperisone Hydrochloride Tablets. [Revised in November 2016] [Accessed on 15th June 2022] https://www.rad-ar.or.jp/siori/english/search/result?n=34882
USEFUL DIAGNOSTIC TESTS
- Liver function test
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 24 Jan 2023 | 08:20 PM(IST)
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