Eparel 50mg Tablet 10'S

Neuropathic Pain Rx required
OUT OF STOCK

Best Price* ₹ 51.60 MRP ₹ 64.50
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mkt: Micro Labs Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

EPAREL 50MG contains Epalrestat which belongs to the group of medicines called Aldose reductase inhibitors. It is used in the treatment of diabetic neuropathy. Diabetic neuropathy is a serious and common complication of type 1 and type 2 diabetes, which is a type of nerve damage that occurs due to long-term high blood sugar levels in diabetic patients that affects most often the legs and feet. It is generally characterized by symptoms such as numbness/reduced ability to feel pain or temperature changes, tingling/burning sensation, sharp pains/cramps, and muscle weakness.

Epalrestat works by inhibiting an enzyme (aldose reductase) which converts glucose into sorbitol. In diabetics, there is an excess sorbitol production that gets deposited in nerves and other tissues, causing diabetic neuropathy. By inhibiting the enzyme, epalrestat delays sorbitol accumulation in nerves and other tissues thus delaying the progression and occurrence of diabetic neuropathy in affected individuals. During treatment with EPAREL 50MG, your doctor will closely monitor you if you have diabetic peripheral neuropathy with irreversible organic changes.

EPAREL 50MG is not recommended for use in patients with allergic to Epalrestat. It should be used with caution in patients with diabetic peripheral neuropathy with irreversible organic changes. EPAREL 50MG should be used with caution in pregnant women only if it is clearly advised by your doctor. It should be used with caution in breastfeeding women after consulting the doctor.

The safety and effectiveness of EPAREL 50MG have not been established in children and adolescents (under 18 years of age), so consult your doctor before taking it. The most common side effects of taking EPAREL 50MG are elevated liver enzymes (signs are dark urine, tiredness, itching, jaundice, and loss of appetite), and/or gastrointestinal disorders such as nausea, vomiting. Contact your doctor if any of these symptoms worsen.

USES OF EPAREL 50MG

  • To treat diabetic neuropathy

HOW EPAREL 50MG WORKS

EPAREL 50MG works by inhibiting an enzyme (aldose reductase) which converts glucose into sorbitol. In diabetics, there is excess production of sorbitol that gets deposited in nerves and other tissues, causing diabetic neuropathy. Thus, by inhibiting the enzyme, EPAREL 50MG delays sorbitol accumulation in nerves and other tissues thereby delaying the progression and occurrence of diabetic neuropathy in affected individuals.

DIRECTIONS FOR USE

Take EPAREL 50MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF EPAREL 50MG

COMMON

  • signs of elevated liver enzymes such as dark urine, tiredness, itching, jaundice (yellowing of your skin or eyes), and loss of appetite
  • gastrointestinal disorders such as nausea, vomiting

HOW TO MANAGE SIDE EFFECTS

Nausea:

Take EPAREL 50MG with, or just after meals. Stick to simple meals. Avoid eating oily, fried or spicy foods. If nausea does not improve, contact your doctor.

Vomiting:

Get adequate rest. Drink lot of fluids, especially water. Have small sips if you feel sick. Do not lie down immediately after eating. Do not take any medicine for vomiting without asking your doctor. If vomiting does not improve, contact your doctor.

WARNING & PRECAUTIONS

PREGNANCY

EPAREL 50MG should be used with caution in pregnant women only if it is considered clearly necessary. Consult your doctor before taking it.

BREASTFEEDING

EPAREL 50MG should be used with caution in breastfeeding women. Consult your doctor before taking it.

KIDNEY

EPAREL 50MG should be used with caution in patients with kidney problems such as renal impairment. Consult your doctor before taking EPAREL 50MG.

ALLERGY

Do not take EPAREL 50MG if you are allergic to Epalrestat or any of the other ingredients of this medicine.

OTHERS

Before taking EPAREL 50MG, inform your doctor if you:

  • have diabetic peripheral neuropathy with irreversible organic changes

Use in pediatrics:

The safety and effectiveness of EPAREL 50MG have not been established in children and adolescents (under 18 years of age). Consult child’s doctor for advice.

Use in geriatrics:

EPAREL 50MG should be used with caution in elderly patients (aged above 70 years). Consult your doctor before taking EPAREL 50MG.

INTERACTIONS

Overdosage:

If you or anyone else accidentally take too much of EPAREL 50MG, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

Drug :   Epalrestat
Pharmacological Category :   Aldose reductase inhibitor
Therapeutic Indication :   Diabetic neuropathy
Dosage Forms :   Tablet

MORE INFORMATION

  • Keep EPAREL 50MG out of reach of children
  • Store at room temperature

FAQs ABOUT EPAREL 50MG

Can EPAREL 50MG be used in children?

As, safety and effectiveness of EPAREL 50MG have not been established in children and adolescents (under 18 years of age). Consult child’s doctor for advice. Your doctor will decide the correct dose or select a suitable alternative therapy for your child.

Can EPAREL 50MG cause vomiting?

Vomiting is a common side effect associated with the use of EPAREL 50MG. To manage this effect, get adequate rest and drink lot of fluids, especially water. Have small sips if you feel sick. Do not lie down immediately after eating. Do not take any medicine for vomiting without asking your doctor. Tell your doctor if you have continuous vomiting.

What precautions do I need to follow while taking EPAREL 50MG?

Patients taking EPAREL 50MG must inform their doctor about their pre-existing conditions like kidney, liver, or heart problems. Patients should also inform if they are pregnant, breast-feeding, or having any allergies. Consult your doctor if you experience any unusual effects.

Can EPAREL 50MG be used during pregnancy?

EPAREL 50MG should be used with caution during pregnancy only if it is clearly advised by your doctor. If you think you are pregnant, or planning to get pregnant, consult your doctor before taking this medicine. Inform your doctor immediately if you become pregnant during treatment with EPAREL 50MG.

Can I take other medicines with EPAREL 50MG?

Before taking EPAREL 50MG, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, non-prescription or any herbal medicine, as these might interact with each other and alter the effect of the medicine.

How does EPAREL 50MG work?

EPAREL 50MG works by inhibiting an enzyme (aldose reductase) which converts glucose into sorbitol. In diabetics, there is an excess sorbitol production that gets deposited in nerves and other tissues, causing diabetic neuropathy. By inhibiting the enzyme, epalrestat delays sorbitol accumulation in nerves and other tissues thus delaying the progression and occurrence of diabetic neuropathy in affected individuals.

REFERENCES

1. KD. Tripathi. Insulin, Oral Hypoglycemic Drugs and Glucagon. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 279.

2. S.R Sharma, Nalini Sharma. Epalrestat, an aldose reductase inhibitor, in diabetic neuropathy: an Indian perspective. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. December 2008. [Accessed on 7th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771994/

3. J W Steele, D Faulds, K L Goa. Epalrestat. A review of its pharmacology, and therapeutic potential in late-onset complications of diabetes mellitus. NIH National Library of Medicine. National center for biotechnology information. PubMed.gov. November 2013. [Accessed on 7th July 2022] https://pubmed.ncbi.nlm.nih.gov/8312678/

4. Mary Ann Ramirez, Nancy L Borja. Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy. NIH. National Library of Medicine. National center for biotechnology information. PubMed.gov. May 2008. [Accessed on 7th July 2022] https://pubmed.ncbi.nlm.nih.gov/18447661/

5. Aaron I. Vinik, Elsa S. Strotmeyer, Abhijeet A Nakave, and Chhaya V Patel. Diabetic Neuropathy in Older Adults. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. August 2009. [Accessed on 7th July 2022] https://pubmed.ncbi.nlm.nih.gov/18447661/

6. Micro Labs Ltd. Eparel 50 Tablets (Epalrestat 50 mg) [Accessed on 7th July 2022] https://www.microlabsltd.com/elibrary/node/1813

USEFUL DIAGNOSTIC TESTS

  • Filament test
  • Sensory test
  • Nerve conduction test
  • Electromyography
  • Autonomic test

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    17.5 g
    Ingredient
    EPALRESTAT 50MG
    Hsn Code
    30049079
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