INTRODUCTION

EOFIL FORTE TABLET is a combination of Chlorpheniramine and Diethylcarbamazine which belongs to the group of medicines called Antiallergics and Filaricides respectively. It is indicated in the treatment of filariasis, tropical pulmonary eosinophilia and loa-loa (eye worm).  

Filariasis is a parasitic disease which affects the lymphatic system of the body and tropical pulmonary eosinophilia a clinical manifestation of filariasis in which these parasites reach the lung tissues.

Prior to the treatment with EOFIL FORTE TABLET your doctor might ask you to undergo several diagnostic tests to understand the existing condition.

EOFIL FORTE TABLET is not recommended for use in patients having heart or kidney disease and have a history of river blindness (onchocerciasis) involving the eyes. EOFIL FORTE TABLET should be used with caution in patients having liver or lung diseases, epilepsy, very high blood pressure and increased pressure in the eye.

EOFIL FORTE TABLET is not recommended for use in pregnant and breast-feeding women. Caution must be exercised while using the medicine in children and not recommended for use in elderly patients especially those with heart or kidney disease.

The most common side effects of taking EOFIL FORTE TABLET are nausea, dry mouth, headache, dizziness or tiredness. Ask for your doctor’s advice if any of these worsen or doesn’t improve.

USES OF EOFIL FORTE TABLET

Treats,

• filariasis
• tropical pulmonary eosinophilia
• loa-loa

HOW EOFIL FORTE TABLET WORKS

EOFIL FORTE TABLET helps in treating parasitic infections where Chlorpheniramine is an H1 Antihistamine which acts by blocking certain chemical substances in the body called histamine which is responsible for allergic symptoms. Diethylcarbamazine is a Filaricide which is thought to destroy the microfilariae (parasites) and also activate the immune system to further kill the parasites.

DIRECTIONS FOR USE

Take EOFIL FORTE TABLET as advised by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, condition and body weight.

SIDE EFFECTS OF EOFIL FORTE TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Take this medicine with or just after a meal or a snack and stick to simple meals and do not eat oil rich, fried or spicy food. Consult your doctor if the symptom does not improve.

Headache:

Try to take rest and don’t involve yourself in exertive activities. Apply a pain-relieving balm on your forehead if necessary.  Consult your doctor if the symptom does not improve.

Dry mouth:

Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug – Drug Interactions:

Before taking EOFIL FORTE TABLET, inform your doctor if you are taking any of the following medicines:

• monoamine oxidase inhibitors (MAOIs) such as isocarboxazid (used to treat depression)
• alprazolam, clonazepam (used to treat anxiety)
• psychotropic drugs such as escitalopram, sertraline (change the perception or behaviour)
• atropine (used to dilate the pupils, treat low heart rate in emergencies)
• phenytoin (used to treat epilepsy)

Overdosage:

If you or anyone else accidentally take too much of EOFIL FORTE TABLET, consult your doctor immediately or visit the nearby hospital. The symptoms of overdosage are nausea, vomiting, headache, vertigo, drowsiness and convulsions (fits).

SYNOPSIS

MORE INFORMATION

• Keep EOFIL FORTE TABLET out of reach of children
• Store at room temperature

FAQs ABOUT EOFIL FORTE TABLET

What is EOFIL FORTE TABLET and why is it prescribed?

EOFIL FORTE TABLET is a combination of Chlorpheniramine and Diethylcarbamazine which belongs to the group of medicines called Antiallergics and Filaricides respectively. It is indicated in the treatment of filariasis, tropical pulmonary eosinophilia and loa-loa (eye worm).

Can EOFIL FORTE TABLET impair my ability to drive?

EOFIL FORTE TABLET can cause drowsiness. Do not drive or operate any machines if you feel drowsy and sleepy after taking EOFIL FORTE TABLET. You can resume with activities as soon as you feel normal again.

Is EOFIL FORTE TABLET safe for children?

EOFIL FORTE TABLET is not recommended for use in children under 2 years of age. It should be used with caution in children as they may experience more side effects relating to the nervous system (such as mind, nerves, muscles and the senses). Consult your child’s doctor for advice.

Can EOFIL FORTE TABLET be given to pregnant and breast-feeding women?

EOFIL FORTE TABLET is not recommended for use in pregnant and breast-feeding women as it is not known if EOFIL FORTE TABLET affects the developing baby or passes through the breast milk. Consult with your doctor before taking it.

Who should not take EOFIL FORTE TABLET?

EOFIL FORTE TABLET is not recommended for use in patients having heart or kidney disease and have a history of river blindness (onchocerciasis) involving the eyes. Ask for your doctor’s advice before taking this medicine.

REFERENCES

1. K.D. Tripathi. Respiratory System Drugs, Antimicrobial Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 220 & 690.

2. Chlorpheniramine. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Accessed on 6th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Chlorpheniramine

3. Diethylcarbamazine. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Accessed on 6th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Diethylcarbamazine

4. Torrent Pharmaceuticals. Unicarbazan Forte (Diethylcarbamazine Citrate and Chlorpheniramine Maleate) Tablets. [Revised in July 2019] [Accessed on 6th July 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2826.pdf

5. Finecure Pharmaceuticals Ltd. Flary Forte (Diethylcarbamazine Citrate and Chlorpheniramine Maleate) Tablets. [Accessed on 6th July 2022] https://www.finecurepharma.com/product/flary-forte/

6. Sapco Laboratories (P) ltd. Dicar Forte (Diethylcarbamazine Citrate and Chlorpheniramine Maleate) Tablets. [Accessed on 6th July 2022] http://www.sapcolaboratories.com/productsearch.asp

USEFUL DIAGNOSTIC TESTS

• Blood smear