ENSAME 200mg Tablet 10's

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Drug Information

What is S-Adenosylmethionine used for?

S-Adenosylmethionine is used for the treatment of following conditions:

  • Depression
  • Osteoarthritis
  • Liver problems
  • Abdominal pain
  • Chronic lower back pain
  • Fibromyalgia
  • Multiple sclerosis
  • Migraine headache
  • Anxiety
  • Tendonitis

S-Adenosylmethionine may also be prescribed for other conditions as determined by the doctor.

How does S-Adenosylmethionine work?

S-Adenosylmethionine belongs to the class of drugs called amino acids. This drug helps in the biosynthesis of essential components, such as DNA, RNA, proteins, phospholipids, epinephrine, creatine, melatonin and other molecules.

How to take S-Adenosylmethionine ?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Take S-Adenosylmethionine as prescribed by your doctor.

Swallow the whole tablet. Do not crush or chew the tablet. Take the drug with or without food. However, taking the drug with food prevents stomach upset.

If you miss a dose of S-Adenosylmethionine, please take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

What are the drugs that interact with S-Adenosylmethionine?

Drugs that interact with S-Adenosylmethionine include the following:

  • Amitriptyline
  • Clomipramine
  • Dextromethorphan
  • Fluoxetine
  • Imipramine
  • Levodopa
  • Meperidine
  • Paroxetine
  • Pentazocine
  • Phenelzine
  • Sertraline
  • Tramadol

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of S-Adenosylmethionine?

The following are the most common side effects of S-Adenosylmethionine:

  • Headache
  • Dizziness
  • Diarrhoea
  • Constipation
  • Increased sweating
  • Insomnia
  • Stomach upset
  • Vomiting
  • Dry mouth
  • Nervousness

The following are the severe side effects and you may require immediate medical attention:

  • Allergic reactions
  • Hives
  • Difficult breathing
  • Swelling of the face

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions S-Adenosylmethionine?

  • Avoid using the medicine if you are allergic to S-Adenosylmethionine or similar drugs.
  • Do not exceed the dose prescribed by the doctor.
  • Consult your doctor before taking S-Adenosylmethionine during pregnancy and breastfeeding.

You are advised not to take S-Adenosylmethionine if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking S-Adenosylmethionine?

  • Tell your doctor if you have any history of kidney diseases.
  • Inform the doctor if you are taking any OTC medications, herbal products or nutritional supplements.
  • Tell your doctor if you are taking any anti-depressant medications.

Frequently Asked Questions about S-Adenosylmethionine

  1. Can S-Adenosylmethionine be used in patients with bipolar disorder?
  2. Avoid using S-Adenosylmethionine medication in patients with bipolar depression disorder as it can lead to increased anxiety and mania.

  3. Is it safe to take S-Adenosylmethionine while on Linezolid medication?
  4. It is not advised to take S-Adenosylmethionine if you have taken MAO inhibitors such as Linezolid during past 2 weeks. Please consult your doctor.

  5. Can I reduce the dose of S-Adenosylmethionine if I feel better?
  6. It is not advised to alter the dose of S-Adenosylmethionine medication without medical supervision.

  7. How should S-Adenosylmethionine be stored?
  8. S-Adenosylmethionine should be stored at room temperature, away from heat, sunlight and excess moisture.

  9. How long can I take S-Adenosylmethionine?
  10. S-Adenosylmethionine should be taken for a prescribed duration of time.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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