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INTRODUCTION
ENPRED contains Difluprednate which belongs to a group of medicines called Corticosteroids. It is used to treat inflammation and pain associated with cataract surgery and endogenous anterior uveitis (inflammation in the middle part of the eye).
Corticosteroid inhibits the inflammatory response to a variety of inciting agents and may delay or slow healing. It also inhibits edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.
Before using ENPRED inform your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding. The common side effects are burning sensation, eye irritation and watery eyes. Avoid touching your eyelids or surrounding areas with the dropper tip of the bottle. If you wear contact lenses, remove them before using this medicine, do not wear a contact lens if your eye is red.
USES OF ENPRED
- Treats inflammation and pain associated with cataract surgery and endogenous anterior uveitis (inflammation in the middle part of the eye)
HOW ENPRED WORKS
ENPRED stimulates the production of certain proteins that prevents the production of other substances that are part of the inflammatory process and reduces the pain and inflammation of cataract surgery and uveitis.
DIRECTIONS FOR USE
Always use ENPRED as instructed by your doctor. Keep bottle tightly closed when not in use.
- Wash your hands and tilt your head back and look at the ceiling
- Gently pull the lower eyelid to make a small pocket
- Turn the bottle upside down and squeeze it smoothly to release one drop into the eyelid pocket
- If you need to use medicine in both eyes, repeat the steps for your other eye
SIDE EFFECTS OF ENPRED
SERIOUS
- hives, breathing difficulty, swelling in the face, lips, tongue, or throat
- vision loss, blurred, tunnel vision, eye pain, eye itching, irritation or redness, severe headache, sensitivity to light, foreign body sensation in eye
- eye swelling, weeping, drainage, crusting
COMMON
- eye irritation
- burning sensation
- watery eyes
HOW TO MANAGE SIDE EFFECTS
Eye irritation:
Place a cold cloth above your closed eyes two to three times a day for five minutes.
WARNING & PRECAUTIONS
PREGNANCY
ENPRED should be used with caution in pregnant women only if the potential benefit justifies the potential risk to the fetus and mother. Consult your doctor for advice.
BREASTFEEDING
ENPRED should be used with caution during breastfeeding. Consult your doctor for advice.
DRIVING AND USING MACHINES
Do not drive or operate machinery while taking this medicine, since it may cause impaired vision.
ALLERGY
Do not use if you are allergic (hypersensitive) to Difluprednate.
OTHERS
Inform your physician if you have or had,
- eye diseases caused by viruses, bacteria or fungus
- eye infection
- allergic to other corticosteroids
- glaucoma
- diabetes
INTERACTIONS
Tell your physician if you are taking,
- ritonavir or cobicistat (used to treat HIV/AIDS)
- NSAIDs
SYNOPSIS
| Drug | : | Difluprednate |
| Pharmacological Category | : | Corticosteroid |
| Therapeutic Indication | : | Inflammation/pain, Uveitis |
| Dosage Forms | : | Ophthalmic emulsion |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT ENPRED
How does ENPRED works?
It stimulates the production of certain proteins that prevents the production of other substances that are part of the inflammatory process and reduces the pain and inflammation of cataract surgery and uveitis.
Can I wear contact lenses while using this ENPRED?
No, do not wear contact lenses prior to administration and wait at least 15 minutes after instilling the medicine.
Is ENPRED effective?
This medicine is effective if used in the dose and duration as directed by your doctor.
REFERENCES
1. Eric D Donnenfeld. Difluprednate for the prevention of ocular inflammation postsurgery: an update. June 15, 2011. [Accessed on June 23, 2021] https://pubmed.ncbi.nlm.nih.gov/?term=Donnenfeld%20ED%5BAuthor%5D&cauthor=true&cauthor_uid=21750615
2. Charu Mithal, Shilpa Singh, Sonali Gupta, Sandeep Mithal. Difluprednate: An Overview. Sep 25, 2013. [Accessed on June 23, 2021] https://www.djo.org.in/articles/23/3/difluprednate-an-overview.html
3. Novartis Pharmaceuticals Canada Inc. [Revised on July 19, 2018] [Accessed on June 23, 2021] Durezol - Novartis Pharmaceuticals Corporationhttps://www.novartis.us › www.novartis.us › files PDF
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