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INTRODUCTION
ENDACE 160MG contain megestrol which belongs to a group of medicine called progestogens. It is used to treat certain types of cancer known as hormone-dependent cancer (including breast cancer). Cancer is a disease in which abnormal cell divide uncontrollably and destroy body tissue. Hormone-dependent cancer is a type of cancer that is dependents on a hormone for growth and/or survival which include breast cancer, which is dependent on estrogens like estradiol.
Hormones are substances produced naturally in the body and they act as chemical messengers and help control the activity of cells and organs. Hormone therapies interfere with the way hormones are made or formed in the body. Many types of cancer depend on hormones to grow. ENDACE 160MG may stop the cancer growing by changing this hormone balance in the body and slows down the growth of cancer. It can also act directly on cancer cell so that they cannot grow.
The most common side effects are increase in appetite, weight gain, hot flushes, high blood pressure, constipation, increased blood sugar levels. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
USES OF ENDACE 160MG
- Treat certain types of cancer known as hormone-dependent cancer (include breast cancer)
HOW ENDACE 160MG WORKS
ENDACE 160MG may stop the cancer growing by changing the hormone balance in the body and slows down the growth of cancer. It can also act directly on cancer cell so that they cannot grow.
DIRECTIONS FOR USE
Always take ENDACE 160MG exactly as your doctor has told you. This medicine must be taken with or without food and try to take at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.
SIDE EFFECTS OF ENDACE 160MG
SERIOUS
- allergic reaction such as swelling of the face, lips, or tongue, skin rash, difficulty breathing
- blood clot (signs include loss of co-ordination, slurred speech, pains in your groin, pains or numbness in your arm or leg (especially in calf of leg), shortness of breath, weakness, headache, and fainting)
COMMON
- increase in appetite and weight gain (not associated with water retention)
- shortness of breath
- hot flushes
- reddening of the face and neck
- high blood pressure
- increased blood sugar levels
- rounded face, sometimes called moon face
- constipation
- swelling of a vein due to a blood clot
- blood clot in the lungs
- temporary increase in the sign and symptom of your disease
- changes in mood
- numbness, pain or tingling in finger or thumb
- heart attack
- hair loss
- diarrhoea, tiredness, feeling weak
- impotence
- passing wind
- needing to urinate more often
- nausea and vomiting
- changes in vaginal bleeding (breakthrough bleeding, spotting)
- build-up of fluid which causes swelling (mainly in the ankles)
- pain
- rash, including hives or nettle rash (urticaria)
HOW TO MANAGE SIDE EFFECTS
Constipation:
Take fibre rich foods such as fresh fruit, vegetables and cereals and drink plenty of water. Exercise more regularly.
Diarrhoea:
Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without talking to a doctor.
Nausea and vomiting:
Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
WARNING & PRECAUTIONS
PREGNANCY
ENDACE 160MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
ENDACE 160MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
ENDACE 160MG do not usually affect your ability to drive.
ALCOHOL
Consumption of alcohol is not recommended during treatment with ENDACE 160MG.
KIDNEY
ENDACE 160MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
ENDACE 160MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take ENDACE 160MG if you are allergic (hypersensitive) to megestrol or any other ingredients in this medicine.
OTHERS
Tell your doctor if you have:
- currently or have a history of suffering from blood clot (thrombophlebitis)
- have diabetes
- are over 65 years of age
INTERACTIONS
Tell your doctor about all the medicines you use, including prescription and non-prescription medicines and herbal supplements.
SYNOPSIS
| Drug | : | Megestrol |
| Pharmacological Category | : | Antineoplastic Agent, Hormone, Appetite Stimulant, Progestin |
| Therapeutic Indication | : | Hormone-dependent cancer (including breast cancer) |
| Dosage Forms | : | Tablet |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT ENDACE 160MG
Does ENDACE 160MG need to be refrigerated?
No, there is no need to refrigerate. However, this medicine should not be stored above 25°C. It should be stored in original packaging to protect from moisture.
Does ENDACE 160MG stop periods?
No, it does not stop periods.
Can I take ENDACE 160MG during liver disease?
It should be used with caution in patients suffering from liver function impairment or active liver diseases.
REFERENCES
1. J Aisner, N S Tchekmedyian, M Moody, N Tait. High-dose megestrol acetate for the treatment of advanced breast cancer: dose and toxicities. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Apr 1987. [Accessed 15 Dec 2020] https://pubmed.ncbi.nlm.nih.gov/3589708/
2. Haupt Pharma Amareg GmbH; Electronic Medicines Compendium (EMC); [Revised on Sep 2020] [Accessed 15 Dec 2020] https://www.medicines.org.uk/emc/files/pil.11135.pdf
USEFUL DIAGNOSTIC TESTS
- Breast Cancer (CA 15.3/ ER/ PR)
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