INTRODUCTION

ELRIZ XL SYRUP is a combination of Ambroxol and Levocetirizine which belongs to the group of medicines called Mucolytics and Antihistamines respectively. It is used to provide symptomatic relief in allergic bronchitis and asthma associated allergic rhinitis in adults and children (aged 6 years and above).

Allergic bronchitis is a condition that occurs due to inflammation of the bronchial tubes by an allergic reaction which is generally characterized by symptoms such as cough, wheezing, chest tightness and weakness. Allergic asthma is a breathing condition where the airways tighten when an allergen is inhaled such as pollen and mold spores which is generally characterized by symptoms such as shortness of breath, coughing, wheezing and stuffy nose.

Avoid taking ELRIZ XL SYRUP, if you are allergic to Ambroxol, Levocetirizine or cetrizine or have end stage renal disease (kidney failure). Before taking ELRIZ XL SYRUP, inform your doctor if you have liver problems such as hepatic impairment.

ELRIZ XL SYRUP is not recommended for use during pregnancy and in breastfeeding women as it can pass through breastmilk. ELRIZ XL SYRUP is not recommended for use in children (aged 6 to 11 years) with impaired renal function and it is used with caution in children and adolescents (aged below 18 years) after consulting the doctor.

The most common side effects of taking ELRIZ XL SYRUP are headache, excessive sleepiness, dry mouth, weakness and decreased muscle strength. Consult your doctor if any of the side effects worsen.

USES OF ELRIZ XL SYRUP

• Provides symptomatic relief in allergic bronchitis (in adults and children aged 6 years and older)
• Provides symptomatic relief from asthma associated allergic rhinitis (in adults and children aged 6 years and older)

HOW ELRIZ XL SYRUP WORKS

ELRIZ XL SYRUP provides symptomatic relief from allergic bronchitis and asthma associated allergic rhinitis, where Ambroxol provides relief from symptoms of allergic bronchitis and rhinitis by thinning and loosening the mucus in the nose, windpipe and lungs. Levocetirizine provides relief from itching, swelling and rashes by blocking the effects of a chemical messenger called histamine in the body which is responsible for producing allergic reactions in the body.

DIRECTIONS FOR USE

Take ELRIZ XL SYRUP as advised by your physician. Use a measuring or spoon to properly measure the dose. Shake well before use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF ELRIZ XL SYRUP

HOW TO MANAGE SIDE EFFECTS

Headache:

If ELRIZ XL SYRUP causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking ELRIZ XL SYRUP. If headaches last more than a week or severe, inform your doctor.

Dry mouth :

Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.

Nausea:

Try to take ELRIZ XL SYRUP with or just after a meal or a snack. Stick to simple meals. Avoid eating oil rich or spicy food. Consult and inform your doctor if the symptom gets worse.

Constipation:

Try to eat high-fiber foods such as vegetables, cereals, fresh fruit and drink plenty of water. Involve in regular exercise (such as going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate treatments for constipation.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions:

Before taking ELRIZ XL SYRUP, inform your doctor, if you are taking any of the following medicines:

• antipyrine (used to decrease pain and inflammation)
• pseudoephedrine (medicine used to relieve nasal congestion caused by colds, allergies and hay fever)
• ketoconazole (used to treat fungal infections)
• theophylline (used to treat the symptoms of asthma, bronchitis and other lung diseases)
• cimetidine (medicine used to treat stomach acidity and peptic ulcers)
• amoxicillin, cefuroxime, erythromycin, azithromycin (medicines used to treat bacterial infections)
• ritonavir (used to treat HIV)

Overdosage:

If you or anyone else accidentally takes too much of ELRIZ XL SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are drowsiness in adults and initially agitation and restlessness, followed by drowsiness in children.

SYNOPSIS

MORE INFORMATION

• Keep the medicine out of reach of children
• Store ELRIZ XL SYRUP at room temperature

FAQs ABOUT ELRIZ XL SYRUP

What is ELRIZ XL SYRUP used for?

ELRIZ XL SYRUP is used in the treatment of allergic bronchitis and asthma associated allergic rhinitis in adults and children (aged 6 years and above) which are generally characterized symptoms such as cough, wheezing, chest tightness, weakness, shortness of breath and stuffy nose.

Who should avoid taking ELRIZ XL SYRUP?

ELRIZ XL SYRUP is not recommended for use in pregnant and breastfeeding women and in children below 6 years of age especially with renal impairment. It is not recommended to be used by patients who are allergic to Ambroxol, Levocetirizine or cetirizine and in patients who have end stage renal disease (kidney failure).

What are the side effects of ELRIZ XL SYRUP?

The most common side effects of taking ELRIZ XL SYRUP are headache, excessive sleepiness, dry mouth, weakness and decreased muscle strength. Consult your doctor if any of the side effect worsens.

What happens if you take more ELRIZ XL SYRUP than your required dose?

If you or anyone else accidentally takes too much of ELRIZ XL SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are drowsiness in adults and initially agitation and restlessness, followed by drowsiness in children.

Can ELRIZ XL SYRUP be taken by pregnant or breastfeeding women?

ELRIZ XL SYRUP is not recommended for use in pregnant women. It is also not recommended to be used in breastfeeding women since it may pass through mother’s milk. Consult your doctor before taking this medicine.

REFERENCES

1. KD. Tripathi. Drugs for Cough and Bronchial Asthma and Histamine and Antihistaminics. Seventh edition. 2013. Page – 167 & 219

2. Boehringer Ingelheim. Relative Bioavailability of Ambroxol Hydrochloride Lozenge in Comparison to Ambroxol Hydrochloride Syrup (Mucosolvan) in Healthy Female and Male Volunteers. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in July 2014] [Accessed on 17th June 2022] https://clinicaltrials.gov/ct2/show/NCT02194296

3. UCB Pharma. Efficacy and Safety of Levocetirizine for Treatment of Recurrent Cough Associated With Other Allergic Symptoms in Children. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in December 2013] [Accessed on 17th June 2022] https://www.clinicaltrials.gov/ct2/show/NCT00520754

4. Zuventus HealthCare Ltd. Elriz Xl Syrup.  [Revised in 2013] [Accessed on 17th June 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=143

5. Delpharma Reims. Mucosolvan forte. [Revised in March 2013] [Accessed on 17th June 2022] https://pharmacia1.com/wp-content/uploads/2015/08/mucosolvan-patient-info.-leaflet.pdf

6. UCB, Inc. U.S. Food & Drug Administration. [Revised in January 2008] [Accessed on 17th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/022064s009lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Sputum test
• Lung function test
• IgE antibody test