INTRODUCTION

EGLUCENT RAPID 100IU contains Insulin lispro which belongs to the group of medicines called rapid-acting human insulin analog. It is used to treat diabetes mellitus in adults who requires a daily dose of more than 20 units of rapid-acting insulin. Diabetes mellitus is a chronic disease associated with abnormally high levels of glucose in the blood due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) or inadequate sensitivity of cells to the action of insulin.

Insulin lispro is indicated to improve long-term glycemic control in patients with diabetes. It works more faster than normal human insulin because insulin lispro is closely related to human insulin (hormone made by pancreas). Always consult your doctor before doing any physical activity and be careful about the time intervals between your meals.

This medicine should only be injected with a pre-filled reusable pen. It can be taken within 15 minutes of a meal or soon after a meal. Do not repeatedly inject this medicine at the same site as it may create a lumpy area under your skin. Try to inject the medicine by rotating to its adjacent areas apart from previous sites to prevent skin changes such as lumps under the skin. To prevent the possible transmission of disease, avoid sharing your needles or pen and only use only a new needle each time.

Avoid smoking and consumption of alcohol while taking this medicine. Regularly monitor your blood sugar levels, because this medicine may cause hypoglycemia which may put your life in danger. The most common side effect of this medicine is application site redness, itching or swelling. Before taking this medicine inform your doctor if you have any kidney, liver or heart disease.

USES OF EGLUCENT RAPID 100IU

• Treats diabetes mellitus in adults

HOW EGLUCENT RAPID 100IU WORKS

Insulin lispro binds to the alpha subunit of insulin receptor and stimulates the tyrosine kinase activity. This stimulation causes phosphorylation of various insulin receptor substrates proteins. This in turn, leads to the activation of downstream signaling molecules including PI3 kinase and Akt, which plays a critical role in glucose metabolism.

DIRECTIONS FOR USE

Take EGLUCENT RAPID 100IU as directed by your physician. It should be taken within 15 minutes of a meal or soon after a meal. Carefully inject this medicine under the skin (subcutaneously) of the stomach area, back of upper arms, upper legs or buttocks. Do not inject this medicine into a muscle or vein without consulting your doctor. Your doctor will decide the correct dose, duration and time for you depending upon your age, weight and body condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF EGLUCENT RAPID 100IU

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after meals. Stick to simple meals. Do not eat rich or spicy food.

Application site reactions (such as redness, swelling or itching)

Avoid hot showers because hot water can irritate the skin. Do not rub or scratch the affected area. Regularly use moisturizers to soothe and hydrate the affected area. If it does not get better, speak to a doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor, if you are taking:

• other medicines used to treat diabetes orally (e.g. metformin, acarbose, pioglitazone, empagliflozin, sitagliptin or saxagliptine)
• medicines used to treat high blood pressure, heart problems and kidney damage due to diabetes such as beta-blockers (e.g. metoprolol, atenolol, propranolol), ACE inhibitors (e.g. captopril, enalapril) or angiotensin II receptor blockers (e.g. losartan, valsartan)
• medicines used to treat depression (e.g. sertraline, fluoxetine, citalopram, escitalopram, or selegiline)
• contraceptive pill (birth control pills)
• steroids (used to treat inflammation) e.g. dexamethasone
• thyroid hormone replacement therapy (used to treat thyroid disorders)
• acetyl salicylic acid (used to treat pain)
• sulphonamide antibiotics (used to treat bacterial infection) e.g. sulphasalazine, sulfamethoxazole
• octreotide (used to treat abnormally high levels of growth hormones)
• salbutamol or terbutaline (used to treat asthma)
• ritodrine (used to stop premature labour)
• danazol (used to treat endometriosis)

SYNOPSIS

MORE INFORMATION

Store in a refrigerator (2°C to 8°C) and keep out of reach of children.

FAQs ABOUT EGLUCENT RAPID 100IU

Can EGLUCENT RAPID 100IU be mixed with NPH?

Do not mix the contents of this medicine with any other insulin or any other medicine directly.

Can EGLUCENT RAPID 100IU be given I.V.?

No. Do not inject this medicine into the vein (intravenously). Always inject this medicine under the skin (subcutaneously) of the stomach area, back of upper arms, upper legs or buttocks.

Can EGLUCENT RAPID 100IU cause diarrhea?

It is generally safe and does not induce diarrhea. However, if you experience any unusual side effects after taking this medicine, consult your doctor immediately.

REFERENCES

1. Alvin C. Powers and David D’Alessio. Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycemia. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page - 1250.

2. KD. Tripathi. Insulin, oral hypoglycaemic drugs and glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 265.

3. Eli Lilly and Company. Study of Insulin Lispro in Participants with Inadequately Controlled Type 2 Diabetes (AUTONOMY). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on April 2014] [Accessed 13th November 2020] https://clinicaltrials.gov/ct2/show/NCT01215955

4. A L Puttagunta and E L Toth. Insulin lispro (Humalog), the first marketed insulin analogue: indications, contraindications and need for further study. NCBI; PMC National Library of Medicine, National Institute of Health. February 1998. [Accessed 13th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1228925/

5. Eli Lilly and Company Limited. Electronic Medicines Compendium (EMC); [Revised on September 2020] [Accessed 13th November 2020] https://www.medicines.org.uk/emc/files/pil.3725.pdf

6. Sanofi-Aventis Deutschland GmbH. Electronic Medicines Compendium (EMC); [Revised on July 2020] [Accessed 13th November 2020] https://www.medicines.org.uk/emc/files/pil.9263.pdf

7. Eli Lilly and Company Limited. Electronic Medicines Compendium (EMC); [Revised on September 2020] [Accessed 13th November 2020] https://www.medicines.org.uk/emc/files/pil.7464.pdf

8. Eli Lilly and Company. humalog-pen. [Revised on November 2019] [Accessed 13th November 2020] https://pi.lilly.com/us/humalog-pen-pi.pdf

USEFUL DIAGNOSTIC TESTS

• Fasting plasma glucose (FPG) test
• Random plasma glucose (RPG) test
• Glucose challenge test
• Oral glucose tolerance test (OGTT)