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INTRODUCTION
EC PAN contains Pantoprazole which belongs to the group of medicines called proton pump inhibitors. It is used to treat reflux oesophagitis (inflammation of oesophagus with regurgitation of stomach acid), stomach and duodenal ulcers, Zollinger-Ellison-Syndrome and other conditions where, too much acid are produced in the stomach. It reduces the amount of acid produced in your stomach and will only be given to you if your doctor thinks that it is more suitable for you than pantoprazole tablets at the moment.
Pantoprazole decreases stomach acid production by inhibiting the proton pump (H+ K+ ATPase). Along with this treatment, your doctor might recommend you, to take enough rest and drink plenty of fluids. Sticking to simple meals and avoiding rich or spicy food can also be beneficial. Avoid smoking and consumption of alcohol during this therapy, as it may reduce the chances of healing and worsen the ulcers.
Always take this medicine as directed by your physician, because long-term use of pantoprazole may reduce your blood magnesium levels, affect liver function or increase the risk of bone fracture. To avoid this, regular monitoring of bone functions, liver enzymes and blood magnesium levels are required during the course of treatment.The most common side effects of this medicine are vomiting, stomach pain and diarrhea. Contact your doctor if any of these symptoms bothers you. Before taking this medicine, inform your doctor if you have any liver disease. If you are pregnant or breast-feeding, consult your doctor for advice before taking this medicine. This medicine is strictly not recommended for use in children and adolescents under 18 years of age. Consult your doctor before taking.
USES OF EC PAN
- Treats reflux oesophagitis
- Treat stomach and duodenal ulcers
- Treats Zollinger-Ellison-Syndrome
HOW EC PAN WORKS
Pantoprazole binds to and irreversibly inhibits the enzyme called H+ K+ ATPase (proton pump) in the parietal cells of the stomach, which decreases gastric acid secretions and can reduce the symptoms associated with pain and inflammation of stomach wall.
DIRECTIONS FOR USE
This medicine will be given to you only a doctor or a nurse into a vein (intravenous infusion). Your doctor will decide the correct dose and duration for you depending upon your age, weight and health condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
SIDE EFFECTS OF EC PAN
SERIOUS
- serious allergic reactions (such as skin rash, swelling of tongue and/or throat, difficulty in swallowing, hives (nettle rash), difficulties in breathing, allergic facial swelling, severe dizziness, fast heartbeat, heavy sweating)
- signs of liver or kidney damage (yellowing of skin or whites of eyes, fever, rash, painful urination, and lower back pain)
COMMON
- thrombophlebitis (inflammation of the wall of the vein and blood clotting)
- benign polyps in the stomach
- vomiting (dark coffee grounds in your vomit)
- blood in your stools
- looking pale or weak
- stomach pain
- chest pain
- diarrhea
RARE
- lack of sense of taste
- blurred vision
- joint pain or muscle pain
- changes in weight
- high fever
- swelling of extremities
- depression
- breast enlargement in males
HOW TO MANAGE SIDE EFFECTS
Skin rash:
Avoid hot showers because hot water can irritate the skin. Do not rub or scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use moisturizers to soothe and hydrate the affected area. If it does not get better, speak to your doctor.
Vomiting:
Try taking this medicine with, or just after meals. Stick to simple meals. Do not eat rich or spicy food.
WARNING & PRECAUTIONS
PREGNANCY
EC PAN should be used in pregnant women only if it is clearly necessary. Consult your doctor for advice before taking this medicine.
BREASTFEEDING
EC PAN can be excreted into the breast milk and so it is not recommended for use in breastfeeding women. Consult your doctor for advice before taking.
DRIVING AND USING MACHINES
Do not drive or operate any machines if your ability is affected by this medicine.
ALCOHOL
Avoid consumption of alcohol while taking this medicine.
LIVER
EC PAN should be taken with caution in patients with severe liver disease. Consult your doctor for advice before taking.
ALLERGY
Do not take this medicine if you are allergic (hypersensitive) to Pantoprazole or any other similar proton pump inhibitors.
OTHERS
Before taking this medicine, inform your doctor if you:
- have gastric malignancy
- are going to have any specific blood test (Chromogranin A)
INTERACTIONS
Talk to your doctor, if you are taking,
- medicines used to treat fungal infections (e.g. ketoconazole, itraconazole and posaconazole)
- medicines used to thin your blood (e.g. warfarin and phenprocoumon)
- medicines used to treat HIV-infection (e.g. atazanavir)
- corticosteroids (used to treat inflammation or allergies) e.g. prednisone, dexamethasone, beclomethasone
- erlotinib (used to treat cancer)
- methotrexate (used to treat cancer, psoriasis or rheumatoid arthritis)
- fluvoxamine (used to treat depression and other psychiatric illness)
- rifampicin (used to treat tuberculosis infection)
- St John’s wort (used to treat depression)
SYNOPSIS
| Drug | : | Pantoprazole |
| Pharmacological Category | : | Proton Pump Inhibitors |
| Therapeutic Indication | : | Reflux oesophagitis, Duodenal or stomach ulcers, Zollinger-Ellison-Syndrome |
| Dosage Forms | : | Tablet, Capsule, Injection |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT EC PAN
How long does it take for EC PAN to work?
This medicine will generally take up to 2-3 days to show its effects and make you feel better. It may also take up to 4 weeks for some individuals depending upon their severity of disease.
Will EC PAN cause weight gain?
This medicine may rarely cause weight gain in some individuals over long-term treatment. Consult your doctor if this symptom bothers you. Try to exercise more regularly, for example, by going for a daily walk or run.
What are the uses of EC PAN?
This medicine is used to treat reflux oesophagitis, stomach and duodenal ulcers and Zollinger-Ellison-Syndrome in adults.
Can EC PAN be used in children?
This medicine is strictly not recommended for use in children and adolescents under 18 years of age. Consult your doctor before taking.
REFERENCES
1. KD. Tripathi. Drugs for Peptic ulcer and Gastroesophageal Reflux Disease. Essentials of medical pharmacology. Seventh edition. 2013. Page – 651-653.
2. John L. Wallace and Keith A. Sharkey. Pharmacotherapy of Gastric acidity, Peptic ulcer and Gastroesophageal Reflux disease. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1311-1313.
3. Gerald G. Briggs and Roger K. Freeman. R. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2960-2965.
4. Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Efficacy and Safety of L-Pantoprazole Sodium Injection to Treat Upper Gastrointestinal Ulcer Bleeding. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on April 2014] [Accessed 24th November 2020] https://clinicaltrials.gov/ct2/show/NCT02108756
5. Andrzej Dabrowski, Borut Štabuc, and Leonid Lazebnik. Meta-analysis of the efficacy and safety of pantoprazole in the treatment and symptom relief of patients with gastroesophageal reflux disease – PAN-STAR. NCBI; PMC US National Library of Medicine, National Institute of Health. March 2018. [Accessed 24th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894447/
6. Mandana Moradi, Samaneh Raeesi, and Zahra Sepehri. Audit of IV pantoprazole: pattern of administration and compliance with guideline in a teaching hospital. NCBI; PMC US National Library of Medicine, National Institute of Health. October 2016. [Accessed 24th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055508/
7. Pfizer. PROTONIX IV (Pantoprazole sodium). Pfizer medical information. [Accessed 24th November 2020] https://www.pfizermedicalinformation.com/en-us/protonix-iv?section=warnings
8. Sun Pharmaceutical Industries Europe B.V. Electronic Medicines Compendium (EMC); [Revised on June 2020] [Accessed 24th November 2020] https://www.medicines.org.uk/emc/files/pil.2833.pdf
9. Exela Pharma Sciences, LLC. U.S. Food & Drug Administration; [Revised on June 2017] [Accessed 24th November 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209463s000lbl.pdf
10. Wyeth Pharmaceuticals Inc. U.S. Food & Drug Administration; [Revised on May 2011] [Accessed 24th November 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020988s043lbl.pdf
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