DYRONIB 70 Tablet 60's

INTRODUCTION

DYRONIB 70 TABLET contains Dasatinib which belongs to the group of medicines called Tyrosine Kinase Inhibitor. It is used to treat cancers of blood and bone marrow (such as chronic myeloid leukaemia (CML) or Philadelphia chromosome positive (Ph+) acute lymphoblastic leukaemia) in adults, adolescents and in children (aged 1 year or above).

It is primarily used in patients when treatment with conventional therapies is not suitable or fails to provide adequate response.

Leukaemia is the cancer of blood cells. It is caused due to abnormal growth and multiplication of blood cells within the bone marrow. It is characterized by severe tiredness, breathlessness, increased bleeding tendency, tiredness, anemia, night sweats, fever, chills, frequent infections and weight loss.

During treatment with DYRONIB 70 TABLET your doctor will closely monitor your health condition through several blood tests to avoid the risk of unwanted side effects. Avoid eating grapefruit or drinking grapefruit juice while taking DYRONIB 70 TABLET as it may increase the risk of side effects.

Before taking DYRONIB 70 TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have or at risk of developing hepatitis C infection as a precaution.

Avoid concomitant use of antacids or any stomach medicines along with DYRONIB 70 TABLET. Leave a time gap of at least 2 hours between the medicines. DYRONIB 70 TABLET is not recommended for use in pregnant or breastfeeding women.

Men and women taking DYRONIB 70 TABLET must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with DYRONIB 70 TABLET.

The most common side effects of taking DYRONIB 70 TABLET are increased bleeding tendency, increased infections, feeling tired or weak, nausea, vomiting, hair loss, mouth ulcers, changes in taste, inflammation of the food pipe or stomach, muscle pain or spasm, skin rashes, headache, dizziness and weight loss. Contact your doctor if any of these side effect worsens.

USES OF DYRONIB 70 TABLET

It is used in adults, adolescents and in children (aged 1 year or above) to treat:

• Cancers of blood and Bone marrow (such as chronic myeloid leukaemia or (Ph+) acute lymphoblastic leukaemia)

HOW DYRONIB 70 TABLET WORKS

DYRONIB 70 TABLET is an anti-cancer medicine. It works by blocking the actions of certain proteins (such as BCR-ABL, Src kinase, etc.) in the body that triggers cancer formation. As a result, it reduces abnormal growth and multiplication of cancer cells in the body.

DIRECTIONS FOR USE

Take DYRONIB 70 TABLET as advised by your physician. It can be taken with or without meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Try to take DYRONIB 70 TABLET at the same time each day. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking DYRONIB 70 TABLET unless advised by your doctor.

SIDE EFFECTS OF DYRONIB 70 TABLET

HOW TO MANAGE SIDE EFFECTS

Skin rash:

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.

Nausea and Vomiting:

Stick to simple meals. Avoid eating oil rich or spicy foods. If your nausea worsens, consult your doctor for advice.

Mouth ulcers:

Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.

Diarrhoea:

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.

Constipation:

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatments for constipation.

WARNING & PRECAUTIONS

PREGNANCY

DYRONIB 70 TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, inform your doctor before taking DYRONIB 70 TABLET if you are pregnant or think you may be pregnant. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with DYRONIB 70 TABLET.

BREASTFEEDING

DYRONIB 70 TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Therefore, consult your doctor taking it.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines if you feel dizzy after taking DYRONIB 70 TABLET.

ALCOHOL

Avoid consumption of alcohol while taking DYRONIB 70 TABLET as it could make you feel dizzier.

KIDNEY

DYRONIB 70 TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

LIVER

DYRONIB 70 TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.

ALLERGY

Do not take DYRONIB 70 TABLET if you are allergic to Dasatinib.

HEART DISEASE

DYRONIB 70 TABLET should be used with caution in patients with heart problems. Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug Interactions:

Before taking DYRONIB 70 TABLET, inform your doctor, if you are taking any of the following medicines such as:

• medicines used for blood thinning (Ex. warfarin)
• ketoconazole, itraconazole (used to treat fungal infection)
• medicines used to treat bacterial infection (such as erythromycin, clarithromycin, telithromycin)
• ritonavir (a medicine used to treat HIV infection)
• medicines used to treat epilepsy (Ex. phenytoin, carbamazepine, phenobarbital)
• rifampicin (a medicine used to treat tuberculosis)
• medicines used to treat stomach ulcers (such as famotidine, omeprazole)
• St. John’s wort (an herbal preparation used to treat depression)
• antacids (used to neutralize stomach acids) Ex. aluminium hydroxide or magnesium hydroxide

B. Drug-Food Interactions:

Avoid eating grapefruit or drinking grapefruit juice while taking DYRONIB 70 TABLET as it may increase the risk of side effects.

Overdosage:

If you or anyone else accidentally took more DYRONIB 70 TABLET, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep DYRONIB 70 TABLET out of reach of children
• Store DYRONIB 70 TABLET at room temperature

FAQs ABOUT DYRONIB 70 TABLET

What DYRONIB 70 TABLET is used for?

DYRONIB 70 TABLET is used to treat cancers of blood and bone marrow (such as chronic myeloid leukaemia (CML) or Philadelphia chromosome positive (Ph+) acute lymphoblastic leukaemia) in adults, adolescents and in children (aged 1 year or above). It is primarily used in patients when treatment with conventional therapies is not suitable or fails to provide adequate response.

How DYRONIB 70 TABLET works on my body?

DYRONIB 70 TABLET is an anti-cancer medicine. It works by blocking the actions of certain proteins (such as BCR-ABL, Src kinase, etc.) in the body that triggers cancer formation. As a result, it reduces abnormal growth and multiplication of cancer cells in the body.

Can DYRONIB 70 TABLET cure cancer?

The cure rate of cancer depends upon the severity of the disease. However, DYRONIB 70 TABLET acts by preventing the abnormal growth and multiplication of cancer cells in the body, which may help in curing cancer completely.

Can the use of DYRONIB 70 TABLET cause hair loss?

Hair loss is one of the common side effects of taking DYRONIB 70 TABLET. If it bothers you, consult your doctor for advice.

Can the use of DYRONIB 70 TABLET cause mouth ulcers?

Mouth ulcers are one of the common side effects of taking DYRONIB 70 TABLET. Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.

Can DYRONIB 70 TABLET be used in children?

DYRONIB 70 TABLET can be used in children and adolescents (aged 1 year or above) if prescribed by the physician. It should not be used in children aged below 1 year due to increased risk of side effects.

Is DYRONIB 70 TABLET a chemo drug?

Yes. DYRONIB 70 TABLET contains a medicine called Dasatinib which is a chemotherapeutic agent. It stops abnormal growth and multiplication of cancer cells in the body.

What happens if I forgot to take a dose of DYRONIB 70 TABLET?

If you forgot to take a dose of DYRONIB 70 TABLET, take it as soon as you remember. However, if it is time for the next dose of DYRONIB 70 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of DYRONIB 70 TABLET to compensate the missed ones.

What precautions must be followed while taking DYRONIB 70 TABLET?

Before taking DYRONIB 70 TABLET inform your doctor if you have any liver, kidney or heart problems or if you have or at risk of developing hepatitis C infection as a precaution. Avoid eating grapefruit or drinking grapefruit juice while taking DYRONIB 70 TABLET. Leave a time gap of at least 2 hours between DYRONIB 70 TABLET and stomach medicines. Inform your doctor before taking DYRONIB 70 TABLET if you are pregnant or breastfeeding women. Men and women taking DYRONIB 70 TABLET must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with DYRONIB 70 TABLET.

Will taking a higher dose of DYRONIB 70 TABLET be more effective?

No, taking a higher dose of DYRONIB 70 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

What happens if I stop taking DYRONIB 70 TABLET?

No. Do not stop taking DYRONIB 70 TABLET without consulting your doctor as it may make your symptoms reappear. Therefore, take DYRONIB 70 TABLET as advised by your doctor for the stipulated duration.

Can DYRONIB 70 TABLET be used during pregnancy?

DYRONIB 70 TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, inform your doctor before taking DYRONIB 70 TABLET if you are pregnant or think you may be pregnant.

Can the use of DYRONIB 70 TABLET make me feel tired?

Yes. DYRONIB 70 TABLET may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after taking DYRONIB 70 TABLET. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while taking this medicine.

Can I drive a car after taking DYRONIB 70 TABLET?

DYRONIB 70 TABLET may make you feel tired or dizzy. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by DYRONIB 70 TABLET.

How to take DYRONIB 70 TABLET?

Take DYRONIB 70 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. DYRONIB 70 TABLET can be taken with or without food.

How to control nausea caused due to DYRONIB 70 TABLET?

Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with DYRONIB 70 TABLET. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.

What are the side effects of taking DYRONIB 70 TABLET?

The most common side effects of taking DYRONIB 70 TABLET are increased bleeding tendency, increased infections, feeling tired or weak, nausea, vomiting, hair loss, mouth ulcers, changes in taste, inflammation of the food pipe or stomach, muscle pain or spasm, skin rashes, headache, dizziness and weight loss. Contact your doctor if any of these side effect worsens.

Who should avoid taking DYRONIB 70 TABLET?

DYRONIB 70 TABLET is not recommended for use if you are allergic to dasatinib. It is also not recommended for use in pregnant or breastfeeding women and in children (aged below 1 year).

Is DYRONIB 70 TABLET safe to use in kidney disease?

DYRONIB 70 TABLET should be used with caution in patients with kidney problems. Your doctor will access your health condition and suggest a suitable dose for you.

Can the use of DYRONIB 70 TABLET affect the liver?

Yes. DYRONIB 70 TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.

REFERENCES

1. Laurence Brunton. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies and Cytokines. Goodman and Gillman’s: The Pharmacological Basics of Therapeutics. Twelfth Edition. 2011. Page – 1732-1734.

2. Dilek Keskin, Sevil Sadri, Ahmet Emre Eskazan. Dasatinib for the treatment of chronic myeloid leukemia: patient selection and special considerations. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. October 2016. [Assessed on 10th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066856/

3. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022]. [Accessed on 10th November 2022] https://www.medicines.org.uk/emc/files/pil.10921.pdf

4. Bristol-Myers Squibb Pharma EEIG. Electronic Medicines Compendium (EMC). [Revised in March 2022]. [Accessed on 10th November 2022] https://www.medicines.org.uk/emc/files/pil.3958.pdf

5. Bristol-Myers Squibb Canada. SPRYCEL. [Revised in November 2021] [Assessed on 10th November 2022] https://www.bms.com/assets/bms/ca/documents/productmonograph/SPRYCEL_EN_PM.pdf

AUTHOR DETAILS

Written By Srilekha. R, B.Pharm
Last updated on 12 Nov 2022 | 10:44 AM(IST)