INTRODUCTION

DUVADILAN RETARD 40MG CAPSULE contains Isoxsuprine which belongs to the group of medicines called Vasodilators. It is used in the treatment of premature labor (when the uterus starts contracting for birth too early than usual), cerebral vascular insufficiency (poor blood flow to the brain) and arteriosclerosis obliterans (hardening of the arteries).

DUVADILAN RETARD 40MG CAPSULE can also be used to treat Buerger's disease (blood vessels become inflamed, swollen and can become blocked with blood clots), Raynaud’s phenomenon (decreased blood flow to the nose, ears, fingers, toes, nipples or knees) and dysmenorrhea (painful menstrual cramps).

DUVADILAN RETARD 40MG CAPSULE should not be used immediately after delivering a baby or if you have a bleeding disorder. DUVADILAN RETARD 40MG CAPSULE is not recommended for use if you have any heart disease (especially arrhythmias), hyperthyroidism, chorioamnionitis, bleeding, eclampsia or pre-eclampsia.

Avoid smoking and consuming alcohol while taking DUVADILAN RETARD 40MG CAPSULE as it may cause dizziness. Do not take DUVADILAN RETARD 40MG CAPSULE if you are pregnant or breastfeeding without consulting your doctor. Safety and effectiveness of DUVADILAN RETARD 40MG CAPSULE in children have not been established.

Your doctor may want you to take blood tests or other medical evaluations during treatment with DUVADILAN RETARD 40MG CAPSULE to monitor progress and side effects. The most common side effects of taking DUVADILAN RETARD 40MG CAPSULE are chest pain or an irregular heartbeat, nausea, vomiting, dizziness or weakness. Contact your physician if any of the symptoms deteriorate.

USES OF DUVADILAN RETARD 40MG CAPSULE

Treats:

• premature labor
• cerebral vascular insufficiency
• arteriosclerosis obliterans
• thromboangitis obliterans (Buerger's disease)
• Raynaud’s phenomenon
• dysmeorrhea

HOW DUVADILAN RETARD 40MG CAPSULE WORKS

DUVADILAN RETARD 40MG CAPSULE prevents premature labor by preventing the contractions of the smooth muscles in the uterus. In peripheral vascular disease, it helps in widening of blood vessels to increase blood flow, thereby improving blood circulation to certain parts of the body (such as the hands/feet and brain).

DIRECTIONS FOR USE

Take DUVADILAN RETARD 40MG CAPSULE as advised by your physician. Swallow the medicines with enough water. Do not crush or chew it. The correct dose and duration will be decided by your physician for you according to your age, body weight and disease condition.

SIDE EFFECTS OF DUVADILAN RETARD 40MG CAPSULE

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Take DUVADILAN RETARD 40MG CAPSULE with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. If symptom persists, contact your doctor.

Dizziness:

Lie or sit down promptly when you feel dizzy. If you're feeling severe episode of spinning, lie in a dark and quite place and close your eyes. Try to avoid vehicle driving. If symptom persists, contact your doctor.

Skin rash:

Avoid hot showers as it can irritate your skin more. Do not scratch the affected area. Use protective clothing when going outdoors and moisturize your skin regularly. If symptom persists, contact your doctor.

WARNING & PRECAUTIONS

PREGNANCY

DUVADILAN RETARD 40MG CAPSULE is not recommended for use in pregnant women unless considered clearly necessary as it is not known whether this medicine will be harmful to an unborn baby. Consult your doctor before taking it.

BREASTFEEDING

DUVADILAN RETARD 40MG CAPSULE is not recommended for use in breastfeeding women unless considered clearly necessary as it is not known whether this medicine passes into breast milk. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive, use any machines or do anything that needs attention if you feel sleepy or dizzy after taking DUVADILAN RETARD 40MG CAPSULE.

ALLERGY

Do not take DUVADILAN RETARD 40MG CAPSULE if you are allergic to Isoxsuprine, lactose or some sugars or to any of the other ingredients of this medicine.

HEART DISEASE

DUVADILAN RETARD 40MG CAPSULE is not recommended for use in patients having heart diseases, especially arrhythmias (irregular heartbeat). Consult your physician before taking it.

INTERACTIONS

A. Drug-Drug interactions:

Before taking DUVADILAN RETARD 40MG CAPSULE, inform your doctor if you are taking any of the following medicines:

• other medicines used to treat low blood pressure (Ex. cilnidipine, phenylephrine)
• other vasodilators (Ex. hydralazine, minoxidil)

Overdosage:

If you or anyone else accidentally take too much of DUVADILAN RETARD 40MG CAPSULE, consult your doctor immediately or visit the nearby hospital. The symptoms of overdosage may include weakness, lightheadedness, fainting, nausea and vomiting.

SYNOPSIS

MORE INFORMATION

• Keep DUVADILAN RETARD 40MG CAPSULE out of reach of children
• Store DUVADILAN RETARD 40MG CAPSULE below 30°C

FAQs ABOUT DUVADILAN RETARD 40MG CAPSULE

Does DUVADILAN RETARD 40MG CAPSULE affect the ability to drive?

DUVADILAN RETARD 40MG CAPSULE causes dizziness and sleepiness. So, avoid driving, doing machinery work or anything that needs attention. Consult your physician for advice.

Can DUVADILAN RETARD 40MG CAPSULE cause bleeding?

DUVADILAN RETARD 40MG CAPSULE might worsen the bleeding and thus it is not recommended for use in patients having bleeding disorders. Consult your doctor if you experience any kind of bleeding and it bothers you.

Can I have alcohol after taking DUVADILAN RETARD 40MG CAPSULE?

Avoid consumption of alcohol while taking DUVADILAN RETARD 40MG CAPSULE as it can increase the dizziness and affect your ability to perform activities that need alertness. Consult your physician for advice.

Is it safe to take DUVADILAN RETARD 40MG CAPSULE in patients with heart problems?

DUVADILAN RETARD 40MG CAPSULE is not recommended for use in patients having heart problems, especially arrhythmias (slow or fast heartbeat). Consult your doctor for advice. The doctor will determine a proper dose of DUVADILAN RETARD 40MG CAPSULE or select a suitable alternative treatment for you.  

Can DUVADILAN RETARD 40MG CAPSULE be used in pregnant women?

DUVADILAN RETARD 40MG CAPSULE is generally not recommended for use in pregnant women unless considered clearly necessary as it is not known whether this medicine will be harmful to an unborn baby. If you are pregnant, think you may be pregnant or are planning to have a baby, consult your doctor before taking it.

REFERENCES

1. K.D. Tripathi. Adrenergic System and Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 136.

2. Azin Alavi, Minoo Rajaee, Malihe Amirian, Hamidreza Mahboobi, Keramat Allah Jahanshahi and Armaghan Faghihi. Effect of Maintenance Therapy with Isoxsuprine in the Prevention of Preterm Labor: Randomized controlled trial. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. August 2015. [Accessed on 9th July 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578532/

3. Jaju PB. Effectiveness and Safety of Isoxsuprine Hydrochloride as Tocolytic Agent in Arresting Active/Threatened Preterm Labor and Its Role in Maintenance Tocolysis: A Prospective, Open-Label Study. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. February 2021. [Accessed on 9th July 2022]. https://pubmed.ncbi.nlm.nih.gov/31550735/

4. FDA.report. Isoxsuprine. [Accessed on 9th July 2022]. https://fda.report/DailyMed/6baec489-724b-4184-9529-7b9ca3573025

5. MK Medicine. Isoxsuprine HCL 40Mg (Sustain Release) Tablet. [Accessed on 9th July 2022]. https://www.mkmedicine.in/isoxsuprine-hcl-40mg-(sustain-release)-tablet.html

6. DM Pharma. Isoxsuprine HCl 40 mg. [Accessed on 9th July 2022]. http://www.dmpharma.co.in/Isoxsuprine%20Tablet.html

7. Aalaina pharma. Isoxsuprine HCl 40 mg. [Accessed on 9th July 2022]. https://alainapharma.com/Isoxsuprine%20Tablet.html

8. Kabir life science. Oxen 10 (Isoxsuprine Hydrochloride Tablets 10 mg). [Accessed on 9th July 2022]. https://www.kabirlifescience.com/product/oxen-10

9. Taj Pharma. Adrenilan (Isoxsuprine Hydrochloride Sustained Release Tablet 10 and 40 mg). [Accessed on 9th July 2022]. https://meds.tajpharma.com/portfolio-item/isoxsuprine-hydrochloride-sustained-release-tablet-adrenilan/

AUTHOR DETAILS

Written By Dr. Jeenal Rajani, Pharm.D.
Last updated on 22 Nov 2022 | 11:42 AM(IST)