DUOVIR Tablet 60's

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Lamivudine 150mg+Zidovudine 300mg
By Cipla Ltd
Prescription Needed
(per unit)
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Drug Information

What is Lamivudine + Zidovudine combination used for?

Lamivudine + Zidovudine combination is an anti-retroviral medicine, which is used for the treatment of human immunodeficiency virus (HIV) infection and chronic hepatitis B infection.

Lamivudine may also be prescribed for other conditions as determined by the doctor.

How does Lamivudine + Zidovudine combination work?

Lamivudine + Zidovudine combination belongs to the class of drugs called reverse transcriptase inhibitors. Lamivudine and Zidovudine prevent the replication of HIV in the human cells. This stops HIV from producing the new viruses and reduces the progression of the disease. This combination is also used to reduce the risk of HIV transmission.

How to take Lamivudine + Zidovudine combination?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Take Lamivudine + Zidovudine combination as prescribed by your doctor.

Swallow the tablet whole. You may also crush the tablet and combine them with a small amount of food or drink if you cannot swallow the tablets whole. You must take the crushed tablet immediately.

If you miss a dose of Lamivudine + Zidovudine combination, please take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

What are the drugs that interact with Lamivudine + Zidovudine combination?

Drugs that interact with Lamivudine + Zidovudine combination include the following:

  • Adalimumab
  • Bexarotene
  • Certolizumab
  • Cladribine
  • Clozapine
  • Co-trimoxazole
  • Dapsone
  • Efavirenz
  • Emtricitabine
  • Ibuprofen
  • Leflunomide
  • Lomitapide
  • Mipomersen
  • Nelfinavir
  • Probenecid
  • Ribavirin
  • Sodium valproate
  • Tenofovir
  • Zalcitabine

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Lamivudine + Zidovudine combination?

The following are the most common side effects of Lamivudine + Zidovudine combination:

  • Diarrhoea
  • Stomach pain
  • Feeling dizzy
  • Tiredness, lack of energy
  • Loss of appetite
  • Fever (high temperature)
  • Difficulty in sleeping (insomnia)
  • Muscle pain and discomfort
  • General feeling of being unwell
  • Irritated or runny nose
  • Joint pain
  • Cough
  • Hair loss

The following are the severe side effects and you may require immediate medical attention:

  • Lactic acidosis
  • Chest pain
  • Swelling of the face, tongue or throat
  • Jaundice
  • Feeling depressed or anxious

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions Lamivudine + Zidovudine combination?

  • Avoid using the medicine if you are allergic to Lamivudine + Zidovudine or similar drugs.
  • Seek doctor’s advice before taking any other drug or herbal products while on Lamivudine + Zidovudine combination.
  • Avoid consumption of alcohol as it may worsen the side effects of Lamivudine + Zidovudine combination.
  • Do not exceed the dose more than what is prescribed.
  • Do not stop using the medication abruptly unless instructed by the doctor. Discontinuing the medication suddenly may cause the illness to return.
  • Be cautious while taking Lamivudine + Zidovudine combination if you have any liver impairment.

You are advised not to take Lamivudine + Zidovudine combination if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discoloration.

What should you tell your doctor before taking  Lamivudine + Zidovudine combination?

  • Tell your doctor if you have any history of muscle problems, abnormal blood cell counts, liver disease, diabetes, nerve or kidney problems.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • Notify your doctor if you are pregnant, planning to become pregnant or breastfeeding.

Frequently Asked Questions about Lamivudine + Zidovudine combination


  1. Can I stop taking Lamivudine + Zidovudine combination if I feel better?
  2. No. Do not discontinue the medicine without consulting your doctor. Abrupt discontinuation may lead to reoccurrence of the disease.

  3. How should Lamivudine + Zidovudine combination be stored?
  4. Store the drug at room temperature and avoid exposure to sunlight and moisture.

  5. What are the other formulations available for Lamivudine + Zidovudine combination?
  6. Lamivudine + Zidovudine combination is available as tablet.

  7. How long can I take Lamivudine + Zidovudine combination?
  8. Lamivudine + Zidovudine combination should be taken till the course is completed. Abrupt discontinuation of the medicine may lead to recurrence of the disease.

  9. Does Lamivudine + Zidovudine combination weaken the bones?
  10. Use of Lamivudine + Zidovudine combination may cause reduced blood supply to certain parts of the bones, which may lead to a condition called osteonecrosis. The symptoms of osteonecrosis include stiffness in the joints, severe pain, and difficulty moving.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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