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INTRODUCTION
DUO 2 EYE DROPS is a combination of Brimonidine and Brinzolamide which belongs to the group of medicines called Ophthalmic anti-glaucoma agents. It is used in adults to treat ocular hypertension and glaucoma (increased pressure within the eyes). It is typically used in patients who are not responding well to therapy with single agents.
DUO 2 EYE DROPS is for ophthalmic use only. Instil few drops of this medicine into the affected eye(s). Do not touch the tip of the dropper with your eye or with other body surface to avoid contamination. If you wear soft contact lenses, remove the lens before using DUO 2 EYE DROPS and wait for at least 15 minutes before reinsertion.
Before using DUO 2 EYE DROPS inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have low or high blood pressure, narrow-angle glaucoma, dry eyes, depression or poor blood circulation in your body as a precaution.
Consult your doctor before using DUO 2 EYE DROPS if you are pregnant or breastfeeding. The most common side effects of using DUO 2 EYE DROPS are eye pain, redness, discomfort, irritation, itching or inflammation, blurred vision and bad taste. Consult your doctor if they trouble you.
USES OF DUO 2 EYE DROPS
- Treats ocular hypertension and glaucoma in adults
HOW DUO 2 EYE DROPS WORKS
DUO 2 EYE DROPS works by decreasing the production of excessive eye fluids (aqueous humour) while simultaneously increasing their drainage. As a result, it reduces strain on the eyes which therefore reduces elevated intraocular pressure.
DIRECTIONS FOR USE
Use DUO 2 EYE DROPS as advised by your doctor. It is for ophthalmic use only. Wash your hands before use. Instil few drops of DUO 2 EYE DROPS into the affected eye. Close your eyes and press the corner of your eye with your finger for a minute.
Do not touch the tip of the dropper with your eye or with other body surface to avoid contamination. Apply applying DUO 2 EYE DROPS, leave a time gap of at least 5 minutes before applying other eye drops or ointment. If you wear soft contact lenses, remove the lens before applying DUO 2 EYE DROPS and wait for at least 15 minutes before reinsertion.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop using DUO 2 EYE DROPS without consulting your doctor, as the pressure within the eye may raise once again.
SIDE EFFECTS OF DUO 2 EYE DROPS
COMMON
- eye redness, itching or inflammation
- eye pain or discomfort
- blurred vision
- drowsiness, dizziness
- bad taste in mouth
- dry mouth
UNCOMMON
- eye swelling, watery eyes
- eye sensitivity towards sunlight eyes
- low blood pressure
- depression
- feeling weak, nervous or irritated
- shortness of breath
- nose bleeds, runny nose, sore throat, cough and cold
- nasal dryness, sneezing
- ringing in the ears
- nausea, vomiting
- skin rash or itching, hair loss
- muscle pain or spasm
- low sex drive, problems in erection
RARE
Stop using DUO 2 EYE DROPS and contact your immediately if you experience any of the following side effects:
- pale skin, sleepiness, low body temperature and breathing difficulties
- severe allergic reactions (such as skin rash, swelling of the eye, eyelids, face, lips, tongue, hands or throat leading to difficulty in breathing)
HOW TO MANAGE SIDE EFFECTS
Eye redness, itching or inflammation:
Wash your eyes with plain cold water. Place an ice pack on your eye to ease the irritation. Avoid straining your eyes by looking at mobile phones, laptops, or television. Wear protective eyeglasses while going outdoors.
Blurred vision:
Close your eyes and relax. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if you experience blurred vision for a prolonged period.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
DUO 2 EYE DROPS is generally not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before using it. Women of childbearing age should use proper contraceptive method to avoid pregnancy while undergoing therapy with DUO 2 EYE DROPS.
BREASTFEEDING
DUO 2 EYE DROPS is generally not recommended for use in breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor before using it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if you experience blurred vision, drowsiness or tiredness after using DUO 2 EYE DROPS.
ALCOHOL
Avoid the consumption of alcohol while using DUO 2 EYE DROPS as it may increase the risk of side effects.
KIDNEY
DUO 2 EYE DROPS is not recommended for use in patients with severe kidney problems. Therefore, consult your doctor before using it.
LIVER
DUO 2 EYE DROPS should be used with caution in patients with liver problems. Therefore, consult your doctor before using it.
ALLERGY
Talk to your doctor if you are allergic to Brimonidine, Brinzolamide, sulphonamides (such as glipizide, gliclazide) or diuretics (such as furosemide).
HEART DISEASE
DUO 2 EYE DROPS should be used with caution in patients with heart diseases (such as coronary heart disease or heart failure). Therefore, consult your doctor before using it.
OTHERS
DUO 2 EYE DROPS is not recommended for use if you:
- have hyperchloremic acidosis (a condition where there is too much of acidity in blood)
Before using DUO 2 EYE DROPS, inform your doctor if you:
- have dry eyes or problems in your cornea
- have narrow angle glaucoma (a type of rapid increase in pressure within the eye)
- have high or low blood pressure
- have depression
- have poor blood circulation in the body (such as Raynaud’s disease)
- have reduced blood supply to the brain or reduced mental capacity
- wear soft contact lenses
Use in pediatrics:
DUO 2 EYE DROPS is generally not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before using it.
Use in geriatrics:
DUO 2 EYE DROPS should be used with caution in elderly patients. Therefore, consult your doctor before using it.
INTERACTIONS
A. Drug-Drug interactions:
Before using DUO 2 EYE DROPS, inform your doctor if you are taking any of the following medicines such as:
- medicines used to treat depression such as (Ex. citalopram, escitalopram, fluoxetine, sertraline, amitriptyline, nortriptyline, moclobemide, selegiline, phenelzine, isocarboxazid, clomipramine, mianserin, venlafaxine and duloxetine)
- medicines used to induce sleep (Ex. alprazolam, midazolam, phenobarbital)
- medicines used to treat mental illness (Ex. chlorpromazine, methylphenidate, reserpine)
- medicines used to lower blood pressure (Ex. enalapril, ramipril)
- digoxin (a medicine used to treat irregular heartbeat)
- anaesthetics (used to induce numbness) Ex. lidocaine
- other carbonic anhydrase inhibitors (used to treat glaucoma) Ex. acetazolamide and dorzolamide
- medicines used to treat viral infections (such as ritonavir, nelfinavir, atazanavir)
- medicines used to treat fungal infections (such as ketoconazole, fluconazole, itraconazole)
- medicines used to treat bacterial infections (such as amoxicillin, cefixime, azithromycin, clarithromycin)
Overdosage:
If you or anyone else accidentally used more DUO 2 EYE DROPS, rinse your eye with warm water. If still irritation persists, consult your doctor.
If you or anyone else accidentally swallowed this medicine, contact your doctor immediately. Symptoms of overdose might include slow heartbeat, low or high blood pressure, difficulty in breathing and confusion or nerve problems.
SYNOPSIS
| Drug | : | Brimonidine, Brinzolamide |
| Pharmacological Category | : | Alpha adrenergic receptor agonists, Carbonic anhydrase inhibitors |
| Therapeutic Indication | : | Glaucoma, Ocular hypertension |
| Dosage Forms | : | Eye drops, Ophthalmic suspension |
MORE INFORMATION
- Keep DUO 2 EYE DROPS out of reach of children
- Store at room temperature
FAQs ABOUT DUO 2 EYE DROPS
How DUO 2 EYE DROPS works?
DUO 2 EYE DROPS works by decreasing the production of excessive eye fluids (aqueous humour) while simultaneously increasing their drainage. As a result, it reduces strain on the eyes which therefore reduces elevated intraocular pressure.
Can the use of DUO 2 EYE DROPS cause blurred vision?
Yes. DUO 2 EYE DROPS may cause blurred vision after application. If your vision becomes blur, close your eyes for some time and rest. Do not strain your eyes by looking at mobile phones, laptops or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if you experience blurred vision for a prolonged period.
Can I use other eye medicines while using DUO 2 EYE DROPS?
Yes. You can use other eye medicines while undergoing therapy with DUO 2 EYE DROPS. But make sure to leave a time gap of at least 5 minutes before applying other eye drops or ointment.
Who should avoid using DUO 2 EYE DROPS?
DUO 2 EYE DROPS should be avoided in patients with severe kidney problems or hyperchloremic acidosis (a condition where there is too much of acidity in blood). It should be used with caution in patients with liver problems, heart problems, depression, dry eyes and problems in blood circulation. It is also not suitable for use in children and in pregnant or breastfeeding women.
How to use DUO 2 EYE DROPS?
Use DUO 2 EYE DROPS as advised by your physician. It is for ophthalmic use only. Instil few drops of the medicine into the affected eye(s). Close your eyes and press the corner of your eye with your finger for a minute. If you wear soft contact lenses, remove the lens before applying DUO 2 EYE DROPS and wait for at least 15 minutes before reinsertion.
What is the use of DUO 2 EYE DROPS?
DUO 2 EYE DROPS is a prescription medicine used in adults to treat glaucoma and ocular hypertension.
How long does it take for [GBNKRYWORD] to work?
It may take about 1 to 4 weeks for DUO 2 EYE DROPS to show the results. Therefore, continue to use DUO 2 EYE DROPS as prescribed by your physician.
What are the side effects of DUO 2 EYE DROPS?
The most common side effects of using DUO 2 EYE DROPS are eye pain, redness, discomfort, irritation, itching or inflammation, blurred vision and bad taste. Consult your doctor if they trouble you.
Can I use DUO 2 EYE DROPS while wearing contact lenses?
If you wear soft contact lenses, remove the lens before applying DUO 2 EYE DROPS and wait for at least 15 minutes before reinsertion. This is because DUO 2 EYE DROPS contains preservatives which may interact with your contact lens and make your lens to discolour.
Can I stop using DUO 2 EYE DROPS without consulting my doctor?
Do not stop using DUO 2 EYE DROPS without consulting your doctor, as the pressure within the eye may raise once again. If you think that you are feeling better or if you wish to stop using DUO 2 EYE DROPS, contact your doctor for advice. Your doctor will check your condition and gradually withdraw the dose.
Is DUO 2 EYE DROPS safe for pregnant and breastfeeding women?
DUO 2 EYE DROPS is generally not recommended for use in pregnant women or breastfeeding women. Therefore, consult your doctor before using it.
Can I drive or ride a bike after using DUO 2 EYE DROPS?
Do not drive if you feel dizzy or experience blurred vision after using DUO 2 EYE DROPS.
What if I miss a dose of DUO 2 EYE DROPS?
If you missed a dose of DUO 2 EYE DROPS, apply it as soon as you remember. However, if it is time for next dose, skip the missed dose and apply the regular dose. Do not apply a double dose to compensate the missed dose.
REFERENCES
1. KD. Tripathi. Anti-Adrenergic Drugs Acting on ANS. Essentials of medical pharmacology. Seventh edition. 2013. Page – 154.
2. Robert F. Reilly and Edwin K. Jackson. Regulation of Renal volume and vascular volume. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 12th Edition. Page – 680.
3. Jed Asher Lusthaus, Ivan Goldberg. Brimonidine and brinzolamide for treating glaucoma and ocular hypertension; a safety evaluation. NIH. National Library of Medicine. National Center of biotechnology Information. Pubmed.gov. September 2017. [Accessed on 12th December 2022] https://pubmed.ncbi.nlm.nih.gov/28656780/
4. Alcon-Couvreur N.V. Electronic Medicines Compendium (EMC). [Revised in May 2022]. [Accessed on 12th December 2022] https://www.medicines.org.uk/emc/files/pil.3290.pdf
5. ALCON LABORATORIES, INC. U.S. Food & Drug Administration. [Revised in April 2013]. [Accessed on 12th December 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/204251s000lbl.pdf
6. Central Drugs Standard Control Organization (CDSCO). Brinzolamide 10mg Brimonidine Tartrate eq. to Brimonidine 2mg Ophthalmic suspension. March 2016. [Accessed on 12th December 2022] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
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