DOTHIPOP 50mg Tablet 10's

INTRODUCTION

DOTHIPOP 50MG contains Dosulepin which belongs to the group of medicines called Antidepressants. It is used in the treatment of depression (mood disorder causing persistent feeling of sadness and loss of interest) and also helps to reduce the feelings of anxiety (intense, excessive, persistent worry and fear about everyday situations), this medicine is used only when other medicines are not suitable.  

DOTHIPOP 50MG is not recommended for use in patients with liver problems, irregular heartbeat or any other heart problems, mania (feeling over excited with unusual behaviour), glaucoma (increased pressure in eye), prostate problems and fits.

Before taking DOTHIPOP 50MG inform your doctor if you have any planned surgeries (such as dental or general surgery), intolerance to certain sugars and thyroid problems. Avoid consumption of alcohol during treatment with DOTHIPOP 50MG as it can make the drowsiness worse.    

DOTHIPOP 50MG should be used in pregnant and breast-feeding women only if clearly advised by the doctor. It is not recommended for use in children and adolescents (below the age of 18 years) and it should be used with caution in elderly patients due to increased risk of certain side effects.  

The most common side effects of taking DOTHIPOP 50MG are dry mouth, blurred vision, dizziness, constipation, sedation and difficulty in passing urine. Consult with your doctor if any of the side effect worsens.  

USES OF DOTHIPOP 50MG

• Treats depression
• Reduce the feelings of anxiety

HOW DOTHIPOP 50MG WORKS

DOTHIPOP 50MG acts on central nervous system (CNS) which works by enhancing the activity of certain neurotransmitters (such as serotonin and noradrenaline) in the brain. It also works by stopping the reabsorption of neurotransmitters into the nerve cells in the brain. Thus, results in prolonging their effects and helps to relieve depression and lighten the mood.

DIRECTIONS FOR USE

Take DOTHIPOP 50MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF DOTHIPOP 50MG

HOW TO MANAGE SIDE EFFECTS

Constipation:

Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatment for constipation.

Dry mouth:

Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.

Dizziness:

Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs. Consult your doctor if the symptom gets worse.

Tiredness:

Drink plenty of fluid and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if the symptom gets worse.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug–Drug Interactions:

Before taking DOTHIPOP 50MG inform your doctor if you are taking any of the following medicines:

• medicines used to treat depression such as selective serotonin reuptake inhibitor (SSRIs) (Ex. citalopram, fluoxetine) and mono-amine oxidase inhibitor (MAOI) (Ex. isocarboxazid, phenelzine)   
• medicines used to treat underactive thyroid (Ex. Levothyroxine)
• medicines used to treat epilepsy (Ex. phenobarbitone), insomnia (Ex. amylobarbitone) and behavioural problems (Ex. methylphenidate)
• medicine containing an opioid (Ex. codeine, morphine, dihydrocodeine, co-proxamol and co-dydramol) (used to treat pain)
• medicines used to treat heart problems and asthma (also as cough and cold remedies), sympathomimetic agents (Ex. ephedrine, pseudoephedrine, adrenaline and noradrenaline)
• medicines used to treat high blood pressure (Ex. guanethidine) and regulate heartbeat (Ex. sotalol)
• terfenadine, astemizole (used to treat hay fever or allergy)
• halofantrine (used to treat malaria)

Overdosage:

If you or anyone else accidentally take too much of DOTHIPOP 50MG, consult your doctor immediately or visit the nearby hospital as it may seriously harm you and cause life-threatening problems.  

SYNOPSIS

MORE INFORMATION

• Keep DOTHIPOP 50MG out of reach of children
• Store at room temperature

FAQs ABOUT DOTHIPOP 50MG

What is DOTHIPOP 50MG and why is it given?

DOTHIPOP 50MG contains Dosulepin which belongs to the group of medicines called Antidepressants. It is used in the treatment of depression and also helps to reduce the feelings of anxiety, this medicine is used only when other medicines are not suitable.  

Can I stop taking DOTHIPOP 50MG on my own?

You should not stop taking DOTHIPOP 50MG suddenly on your own without the advice of your doctor. Your doctor may gradually withdraw the dose in case of stopping the medicine. If you stop taking DOTHIPOP 50MG suddenly you may experience some withdrawal symptoms like irritability, insomnia and excessive perspiration (sweating).

Is DOTHIPOP 50MG safe to use in pregnant and breast-feeding women?

DOTHIPOP 50MG should be used in pregnant and breast-feeding women only if clearly advised by the doctor. Consult your doctor before taking DOTHIPOP 50MG if you are pregnant or planning to get pregnant or breast-feeding your child.

Can I drive or operate heavy machines after taking DOTHIPOP 50MG?

DOTHIPOP 50MG can cause drowsiness. Therefore, it is not advisable to drive or use machineries and tools until you feel normal again. Consult your doctor for advice before taking DOTHIPOP 50MG.

Can DOTHIPOP 50MG be used in elderly patients?

DOTHIPOP 50MG should be used with caution in elderly patients due to increased risk of side effects such as agitation, confusion and light headedness. Consult your doctor before taking it.

REFERENCES

1. KD. Tripathi. Antidepressant and Antianxiety Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 459.

2. T Nakagawa, K Ukai, S Kubo. Antidepressive effects of the stereoisomer cis-dosulepin hydrochloride. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 1993 [Accessed on 14th June 2022] https://pubmed.ncbi.nlm.nih.gov/8447840/

3. P Zusky, T C Manschreck, C Blanchard, J Rosenbaum, C Elliot, P Lou. Dothiepin hydrochloride: treatment efficacy and safety. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. October 1986. [Accessed on 14th June 2022] https://pubmed.ncbi.nlm.nih.gov/3531188/

4. Dosulepin. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Revised in September 2022] [Accessed on 14th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Dosulepin#section=Mechanism-of-Action

5. Teva Pharmaceuticals Works Pvt Ltd. Dosulepin. [Revised in March 2021]. [Accessed on 14th June 2022] https://products.tevauk.com/mediafile/id/50662.pdf

6. Teofarma S.r.l. Health Products Regulatory Authority (HPRA). [Revised in July 2020] [Accessed on 14th June 2022] https://www.hpra.ie/img/uploaded/swedocuments/0cc11c1c-a57e-470f-a788-57d351b29341.pdf