DOTHIN 25mg Tablet 10's

INTRODUCTION

DOTHIN 25MG contains Dosulepin which belongs to the group of medicines called Antidepressants. It is used in the treatment of depression (mood disorder causing persistent feeling of sadness and loss of interest) and also helps to reduce the feelings of anxiety (intense, excessive, persistent worry and fear about everyday situations), this medicine is used only when other medicines are not suitable.  

DOTHIN 25MG is not recommended for use in patients with liver problems, irregular heartbeat or any other heart problems, mania (feeling over excited with unusual behaviour), glaucoma (increased pressure in eye), prostate problems and fits.

Before taking DOTHIN 25MG inform your doctor if you have any planned surgeries (such as dental or general surgery), intolerance to certain sugars and thyroid problems. Avoid consumption of alcohol during treatment with DOTHIN 25MG as it can make the drowsiness worse.    

DOTHIN 25MG should be used in pregnant and breast-feeding women only if clearly advised by the doctor. It is not recommended for use in children and adolescents (below the age of 18 years) and it should be used with caution in elderly patients due to increased risk of certain side effects.  

The most common side effects of taking DOTHIN 25MG are dry mouth, blurred vision, dizziness, constipation, sedation and difficulty in passing urine. Consult with your doctor if any of the side effect worsens.

USES OF DOTHIN 25MG

• Treats depression
• Reduce the feelings of anxiety

HOW DOTHIN 25MG WORKS

DOTHIN 25MG acts on central nervous system (CNS) which works by enhancing the activity of certain neurotransmitters (such as serotonin and noradrenaline) in the brain. It also works by stopping the reabsorption of neurotransmitters into the nerve cells in the brain. Thus, results in prolonging their effects and helps to relieve depression and lighten the mood.

DIRECTIONS FOR USE

Take DOTHIN 25MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF DOTHIN 25MG

HOW TO MANAGE SIDE EFFECTS

Constipation:

Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatment for constipation.

Dry mouth:

Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.

Dizziness:

Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs. Consult your doctor if the symptom gets worse.

Tiredness:

Drink plenty of fluid and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if the symptom gets worse.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug–Drug Interactions:

Before taking DOTHIN 25MG inform your doctor if you are taking any of the following medicines:

• medicines used to treat depression such as selective serotonin reuptake inhibitor (SSRIs) (Ex. citalopram, fluoxetine) and mono-amine oxidase inhibitor (MAOI) (Ex. isocarboxazid, phenelzine)   
• medicines used to treat underactive thyroid (Ex. Levothyroxine)
• medicines used to treat epilepsy (Ex. phenobarbitone), insomnia (Ex. amylobarbitone) and behavioural problems (Ex. methylphenidate)
• medicine containing an opioid (Ex. codeine, morphine, dihydrocodeine, co-proxamol and co-dydramol) (used to treat pain)
• medicines used to treat heart problems and asthma (also as cough and cold remedies), sympathomimetic agents (Ex. ephedrine, pseudoephedrine, adrenaline and noradrenaline)
• medicines used to treat high blood pressure (Ex. guanethidine) and regulate heartbeat (Ex. sotalol)
• terfenadine, astemizole (used to treat hay fever or allergy)
• halofantrine (used to treat malaria)

Overdosage:

If you or anyone else accidentally take too much of DOTHIN 25MG, consult your doctor immediately or visit the nearby hospital as it may seriously harm you and cause life-threatening problems.

SYNOPSIS

MORE INFORMATION

• Keep DOTHIN 25MG out of reach of children
• Store at room temperature

FAQs ABOUT DOTHIN 25MG

What is DOTHIN 25MG and why is it given?

DOTHIN 25MG contains Dosulepin which belongs to the group of medicines called Antidepressants. It is used in the treatment of depression and also helps to reduce the feelings of anxiety, this medicine is used only when other medicines are not suitable.  

Can I stop taking DOTHIN 25MG on my own?

You should not stop taking DOTHIN 25MG suddenly on your own without the advice of your doctor. Your doctor may gradually withdraw the dose in case of stopping the medicine. If you stop taking DOTHIN 25MG suddenly you may experience some withdrawal symptoms like irritability, insomnia and excessive perspiration (sweating).

Is DOTHIN 25MG safe to use in pregnant and breast-feeding women?

DOTHIN 25MG should be used in pregnant and breast-feeding women only if clearly advised by the doctor. Consult your doctor before taking DOTHIN 25MG if you are pregnant or planning to get pregnant or breast-feeding your child.

Can I drive or operate heavy machines after taking DOTHIN 25MG?

DOTHIN 25MG can cause drowsiness. Therefore, it is not advisable to drive or use machineries and tools until you feel normal again. Consult your doctor for advice before taking DOTHIN 25MG.

Can DOTHIN 25MG be used in elderly patients?

DOTHIN 25MG should be used with caution in elderly patients due to increased risk of side effects such as agitation, confusion and light headedness. Consult your doctor before taking it.

REFERENCES

1. KD. Tripathi. Antidepressant and Antianxiety Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 459.

2. T Nakagawa, K Ukai, S Kubo. Antidepressive effects of the stereoisomer cis-dosulepin hydrochloride. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 1993 [Accessed on 14th June 2022] https://pubmed.ncbi.nlm.nih.gov/8447840/

3. P Zusky, T C Manschreck, C Blanchard, J Rosenbaum, C Elliot, P Lou. Dothiepin hydrochloride: treatment efficacy and safety. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. October 1986. [Accessed on 14th June 2022] https://pubmed.ncbi.nlm.nih.gov/3531188/

4. Dosulepin. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Revised in September 2022] [Accessed on 14th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Dosulepin#section=Mechanism-of-Action

5. Teva Pharmaceuticals Works Pvt Ltd. Dosulepin. [Revised in March 2021]. [Accessed on 14th June 2022] https://products.tevauk.com/mediafile/id/50662.pdf

6. Teofarma S.r.l. Health Products Regulatory Authority (HPRA). [Revised in July 2020] [Accessed on 14th June 2022] https://www.hpra.ie/img/uploaded/swedocuments/0cc11c1c-a57e-470f-a788-57d351b29341.pdf