DIVAINE 100 Injection 1's

Bacterial Infections Rx required

Best Price* ₹ 2,635.38 MRP ₹ 3,294.22
(Inclusive of all taxes) * Mkt: Cipla Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

DIVAINE 100 INJECTION contains Minocycline, which belongs to the group of medicines called Antibiotics. It is used to treat certain forms of bacterial infections that affect the ears, eyes, throat, nose and respiratory system (chest infections), gonorrhoea or pelvic, skin infections (acne), urinary tract infections and prostate infections. It also helps in the treatment of meningitis carriers. It is also given for the prevention of infections before and after an operation.

Before taking DIVAINE 100 INJECTION, inform your doctor if you have or ever had liver or kidney problems. Avoid consumption of alcohol, milk or milk products while taking DIVAINE 100 INJECTION, as it may lead to unwanted side effects.

DIVAINE 100 INJECTION should be used with caution among women who are pregnant or breastfeeding as it can affect the development of the unborn baby. DIVAINE 100 INJECTION should be used with caution by adults and adolescents but not recommended for use under the age of 12 years. The most common side effects of taking DIVAINE 100 INJECTION are dizziness and fever. Consult your doctor if any of the symptoms worsen.

USES OF DIVAINE 100 INJECTION

  • Treats upper tract infections, skin infections, acute intestinal amebiasis, severe acne and other bacterial infections
  • Treats meningitis, syphilis, anthrax, actinomycosis and listeriosis

HOW DIVAINE 100 INJECTION WORKS

DIVAINE 100 INJECTION has properties of immunomodulatory, anti-inflammatory and neuroprotective effects. It can work by any of the following mechanism such as inhibitory effect on activities of enzymes such as MMPs or iNOS; reduction in protein tyrosine nitration because of scavenging properties; inhibition of activation of caspase-1 and caspase 3; enhancement of Bcl-2-derived effects which protects the cells against apoptosis; inhibition of the activity of PARP-1; reduction in the amount of p38 MAPK phosphorylation. All these activities of minocycline help in fighting against various bacterial infections.

DIRECTIONS FOR USE

DIVAINE 100 INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF DIVAINE 100 INJECTION

COMMON

  • dizziness

UNCOMMON

  • fever

RARE

  • vertigo (spinning sensation)
  • tinnitus (ringing in ears) and other hearing problems
  • loss of appetite
  • headache
  • diarrhoea
  • feeling or being sick
  • hair loss
  • abnormal and unexplained bruising and bleeding for a longer period. This might indicate low platelet levels in the blood
  • discolouration of teeth
  • cough
  • reduced sense of touch
  • feeling of pins and needles in the hands or feet
  • muscle and joint pain
  • skin problems such as itching, skin rashes, nettle rashes, the appearance of the same skin reaction in the same area after taking medicine and the occurrence of red round lumps under the skin below the knee
  • redness, pain or tenderness, swelling around a vein (vasculitis)
  • increased levels of liver enzymes or urea observed in blood test
  • increase in a specific type of WBCs seen in blood test

Stop taking DIVAINE 100 INJECTION and contact your doctor immediately if you experience any of the following side effects:

  • severe headaches
  • eye problems such as blurred or double vision, loss of vision
  • urine problems such as little or no urine production, discomfort or pain during the passing of urine and the production of dark or cloudy urine with lower back pain. These are indications of serious kidney problems
  • skin problems such as the occurrence of purple painful lumps on the skin (erythema nodosum), patches of dark skin colour, burning, tingling or redness of the skin after exposure to direct or artificial sunlight
  • inflammation is seen in various parts such as the liver, blood vessels, tongue, vagina or mouth and intestines which causes severe nausea and vomiting, stomach cramps or diarrhoea and itching of the anus. These are indicative of the growth of tetracycline-resistance bacteria
  • recurrent and frequent infections causing fever, chest infections, severe chills or mouth ulcers. These are signs of low WBCs levels in the blood
  • dark urine, pale stools, loss of appetite, yellowing of skin or whites of eyes and stomach pain. These are indications of serious liver problems
  • fatigue, chest pain or pressure and shortness of breath during exercise are signs of inflamed heart muscles (myocarditis)
  • sudden sharp chest pain which aggravates by deep breathing or coughing. These are signs of inflammation of the membrane surrounding the heart (pericarditis)
  • muscle pain
  • inflammation, pain, swelling or stiffness of joints with fever
  • allergic reaction is seen as red itchy swollen skin, severe skin rashes and swelling seen on the face, mouth, lips, tongue or throat which results in breathing difficulties
  • tiredness, weakness or pale skin
  • breathing problems such as wheezing, shortness of breath at rest, coughing with chest tightness or worsening of asthma
  • stomach cramps, watery diarrhoea might be with blood, loss of appetite and feeling sick (nausea or being sick). This may be a sign of pancreas inflammation
  • severe skin reactions, blistering of skin, mouth, genitals and eyes, peeling or flaking of skin
  • hair loss, weight loss, fever, rash (especially on the face), generalized feeling of being unwell and pain in joints. These are signs of Systemic Lupus Erythematous
  • fits
  • changes in the level of blood cells (drug reaction with eosinophilia and systemic symptoms – DRESS)

HOW TO MANAGE SIDE EFFECTS

Vomiting

Take DIVAINE 100 INJECTION with or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods. Inform your doctor if the symptoms do not improve or worsen with time.

Dizziness

If your feel dizzy, lie down, close your eyes and relax. Once you start feeling better, get up slowly and not with a jerk. Sit like that for 5-10 minutes and then you can continue working. Inform your doctor if the symptoms do not improve or worsen with time.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much alcohol. Consult your doctor if the symptom worsens.

Diarrhoea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If the symptom does not improve or worsen, contact your doctor.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.

WARNING & PRECAUTIONS

PREGNANCY

DIVAINE 100 INJECTION is generally not recommended for use in pregnant women or women who are planning to conceive, as it can affect the development of the foetus. Consult your doctor before taking it.

BREASTFEEDING

DIVAINE 100 INJECTION is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizziness, spinning sensation while standing, headaches, eyesight problems, light-headedness, ringing in the ears or hearing problems after taking DIVAINE 100 INJECTION.

ALCOHOL

Avoid consumption of alcohol while taking DIVAINE 100 INJECTION. The absorption of DIVAINE 100 INJECTION can be affected by food, milk or milk products.

KIDNEY

DIVAINE 100 INJECTION should be taken with caution in patients with severe kidney disease. Consult your doctor before taking it.

LIVER

DIVAINE 100 INJECTION should be taken with caution in patients with liver disease. Consult your doctor before taking it.

ALLERGY

Do not take DIVAINE 100 INJECTION if you are allergic to minocycline. Also, if you know that you are lactose intolerant, contact your doctor before taking DIVAINE 100 INJECTION.

OTHERS

DIVAINE 100 INJECTION is not recommended for use if you:

  • have systemic lupus erythematosus (an autoimmune disorder where the immune system of the body attacks its tissue causing damage and inflammation of various parts of the body)
  • have a need for dialysis treatment

Before taking DIVAINE 100 INJECTION, inform your doctor if you:

  • have myasthenia gravis (a condition which causes muscle weakening)

Use in paediatrics:

DIVAINE 100 INJECTION is generally not recommended for under 8 years of age as it can affect growing bones and teeth and cause staining of teeth along with reduced enamel content in teeth. Consult your doctor before taking it.

Use in geriatrics:

DIVAINE 100 INJECTION should be used with caution in elderly patients, especially over the age of 65 years. Consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug interactions:

Before taking DIVAINE 100 INJECTION, inform your doctor if you are taking any of the following medicine:

  • anticoagulants (used to thin blood) Ex. warfarin
  • antacids (used to treat indigestion) Ex. – magnesium hydroxide and calcium carbonate
  • hepatotoxic medicine (medicines that might affect the working of the liver)
  • sucralfate and bismuth salts (used to treat ulcers)
  • kaolin (used to treat diarrhoea)
  • quinapril (ACE inhibitor, used to treat high blood pressure)
  • antibiotic (a medicine used to treat infections) Ex. – penicillin
  • diuretics Ex. bumetanide and furosemide
  • retinoids (used to treat acne) Ex. isotretinoin or retinol
  • ergotamine (used to treat migraines)
  • ergometrine (used to induce labour or abortion)
  • medicines containing zinc salts, calcium, iron, magnesium or aluminium

B. Drug-Food Interactions

Avoid drinking alcohol while taking DIVAINE 100 INJECTION as it may increase the risk of side effects. The absorption of DIVAINE 100 INJECTION can be reduced by food, milk or milk products.

Overdosage:

DIVAINE 100 INJECTION will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

SYNOPSIS

Drug :   Minocycline
Pharmacological Category :   Antibiotics
Therapeutic Indication :   Acne
Dosage Forms :   Tablet, Capsules, Injection

MORE INFORMATION

  • Keep DIVAINE 100 INJECTION out of reach from children
  • Store DIVAINE 100 INJECTION at room temperature

FAQs ABOUT DIVAINE 100 INJECTION

Can DIVAINE 100 INJECTION be used in pregnant women?

No, it is not recommended to use DIVAINE 100 INJECTION in pregnant women or if you are planning to get pregnant as it can affect the growth and development of the unborn baby. Consult your doctor before taking it.

How to take DIVAINE 100 INJECTION?

The dosage of DIVAINE 100 INJECTION will be decided by your doctor or pharmacist. But remember to not take DIVAINE 100 INJECTION with food, milk or other milk products as this can reduce the absorption of the medicine. Do not immediately take this medicine after dinner just before bed, rather take it standing or sitting upright.

Can children under the age of 12 years take DIVAINE 100 INJECTION?

No, it is not safe for children under 12 years to take DIVAINE 100 INJECTION as this medicine can affect the development of bone and cause staining of teeth and reduced enamel content in teeth.

Will taking a higher dose of DIVAINE 100 INJECTION be more effective?

No, taking a higher dose of DIVAINE 100 INJECTION will not be effective, rather you might suffer from symptoms of overdose such as nausea, vomiting or dizziness. Consult your doctor immediately if you have accidentally taken a higher dose of DIVAINE 100 INJECTION.

What are the medicines that I should avoid while taking DIVAINE 100 INJECTION?

One should avoid multiple medicines while taking DIVAINE 100 INJECTION such as anticoagulants like warfarin, antacids like magnesium hydroxide, ergotamine for migraines and ergometrine for migraines inducing labour or abortion.

Can someone with lactose intolerance take DIVAINE 100 INJECTION?

No, if you know that you or someone you know, have lactose intolerance or intolerance to some other sugars, consult your doctor before taking DIVAINE 100 INJECTION.

Can we consume alcohol while taking DIVAINE 100 INJECTION?

Avoid alcohol consumption while taking DIVAINE 100 INJECTION as the absorption of the medicine will be reduced. Also, avoid taking milk or milk products or food while taking DIVAINE 100 INJECTION because of reduce absorption.

What should be done if I have missed a dose of DIVAINE 100 INJECTION?

If you miss your dose of DIVAINE 100 INJECTION do not take the missed dose even if you remember it later and follow the scheduled regime for your medicine.

Can we take DIVAINE 100 INJECTION after meals?

No, avoid taking DIVAINE 100 INJECTION after meals or with milk or milk products, as this can lead to reduced absorption of DIVAINE 100 INJECTION and the medicine will not work efficiently.

Is driving safe after taking DIVAINE 100 INJECTION?

No, driving is not safe after taking DIVAINE 100 INJECTION as you may feel dizziness, headaches, light-headedness, spinning sensation while standing, ringing in the ears or other hearing problems and eyesight problems. You should avoid driving or using machines after taking DIVAINE 100 INJECTION.

REFERENCES

1. K.D Tripathi. Tetracyclines and Chloramphenicol (Broad-Spectrum Antibiotics). Essentials of medical pharmacology. Seventh edition. 2013. Page – 733.

2. Thomas P Lodise, Scott Van Wart, Zoe M Sund, Adam M Bressler, Akram Khan, Amy T Makley, Yasir Hamad, Robert A Salata, Fernanda P Silveira, Matthew D Sims, Badih A Kabchi, Mohamed A Saad, Carrie Brown, Randolph E Oler Jr, Vance Fowler Jr, Richard G Wunderink. Pharmacokinetic and Pharmacodynamic Profiling of Minocycline for Injection following a Single Infusion in Critically Ill Adults in Phase IV Open-Label Multicenter Study (ACUMIN). NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. February 2019. [Accessed on 1st June 2022] https://pubmed.ncbi.nlm.nih.gov/33168615/

3. Triax Pharmaceuticals LLC. Electronic Medicines Compendium (EMC). [Revised in August 2010] [Accessed on 1st June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/050444s047lbl.pdf

4. Accord. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed 1st June 2022] https://www.medicines.org.uk/emc/files/pil.5915.pdf

PRODUCT DETAILS

    Net Qty
    1 N
    Hsn Code
    30042049
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DIVAINE 100 Injection 1's

DIVAINE 100 Injection 1's Mkt: Cipla Ltd

M.R.P.: Rs.3,294.22
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