INTRODUCTION

DIOFLOX SUSPENSION contains Ofloxacin, which belongs to the group of medicines called Antibiotics. It is used in children to treat bacterial infections of the eyes, ears, nose, throat, lungs, skin and urinary tract. Bacterial infections are generally characterized by fever, extreme tiredness, swollen lymph nodes in the neck, armpits, groin or elsewhere, headache, nausea or vomiting.

Ofloxacin works by binding to and inhibiting bacterial enzymes required in DNA synthesis, thus interrupting DNA replication and preventing bacterial cell multiplication.

Before using DIOFLOX SUSPENSION, inform your doctor if you have any other conditions or if you are using or taking other medicines. It should be used cautiously in pregnant and breastfeeding women. Your doctor will prescribe the right dose of DIOFLOX SUSPENSION for your child depending on age, body weight and severity of infection.

The most common side effects of taking DIOFLOX SUSPENSION are vomiting, nausea, stomach pain, diarrhea, loss of appetite, headache, difficulty sleeping and dizziness. Contact your doctor if any of the symptoms worsen.

USES OF DIOFLOX SUSPENSION

It is indicated for the treatment of the following bacterial infections in children:

• Eye infection
• Ear infection
• Nose infection
• Throat infection
• Lung infection
• Skin infection
• Urinary tract infection

HOW DIOFLOX SUSPENSION WORKS

DIOFLOX SUSPENSION works by binding to and inhibiting bacterial enzymes required in DNA synthesis, thus interrupting DNA replication and preventing bacterial cell multiplication.

DIRECTIONS FOR USE

Take DIOFLOX SUSPENSION as advised by your physician. Shake well before use. Your doctor will decide the correct dose and duration for you according to your age, body weight and severity of infection.

SIDE EFFECTS OF DIOFLOX SUSPENSION

HOW TO MANAGE SIDE EFFECTS

Nausea:

Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to simple meals. Avoid eating oily or spicy foods. If nausea does not improve, contact your doctor.

Vomiting:

Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like it – you do not need to eat or avoid any specific foods. If vomiting does not improve, contact your doctor.

Headache:

Drink an ample amount of water. Get adequate rest. Try to be relaxed and stress-free. Ask your doctor before taking any medicine for headaches. Consult your doctor immediately if your symptom does not improve.

Dizziness:

Lie down until the dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and drugs. Consult your doctor immediately if your symptom does not improve.

Diarrhea:

Drink lots of fluids, like water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Consult your doctor immediately if your symptom does not improve.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to eat smaller meals more frequently. Keep a heating pad on your stomach. Consult your doctor immediately if your symptom does not improve.

Decreased appetite:

Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you are hungry. Eat a nutritious snack rich in calories and protein, such as dried fruit and nuts. Consult your doctor immediately if your symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY

DIOFLOX SUSPENSION should be used with caution in pregnant women. Consult your doctor before taking it.

BREASTFEEDING

DIOFLOX SUSPENSION should be used with caution in breastfeeding women. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Consult your doctor if you feel any side effects during treatment with DIOFLOX SUSPENSION that may stop you from driving or using machines.

ALLERGY

Do not take DIOFLOX SUSPENSION if you are allergic to Ofloxacin or any of the other ingredients of this medicine or previously had an allergic reaction to any quinolone antibiotic.

INTERACTIONS

A. Drug-Drug interactions:

Before using DIOFLOX SUSPENSION, inform your doctor if you are taking, have taken or might take any other medicine, including prescription, non-prescription or any herbal medicine.

Overdosage:

If you or anyone else accidentally take too much of DIOFLOX SUSPENSION, contact your doctor immediately.

SYNOPSIS

MORE INFORMATION

• Keep DIOFLOX SUSPENSION out of reach from children
• Store below 25°C

FAQs ABOUT DIOFLOX SUSPENSION

Q: Does DIOFLOX SUSPENSION treat urinary tract infections?

A: Yes. DIOFLOX SUSPENSION is used to treat urinary tract infections. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of infection.

Q: Can DIOFLOX SUSPENSION treat typhoid?

A: According to some studies, DIOFLOX SUSPENSION can be used to treat typhoid, in adults who are infected with S. typhi resistant to other medicines like chloramphenicol, ampicillin and cotrimoxazole. However, consult your doctor before giving DIOFLOX SUSPENSION to your child for indications other than prescribed for.

Q: Can DIOFLOX SUSPENSION cause a headache?

A: Yes. DIOFLOX SUSPENSION may cause headache. In such cases, drink an ample amount of water and get adequate rest. Try to be relaxed and stress-free. Ask your doctor before taking any medicine for headaches. If the headache does not improve, contact your doctor.

Q: What if I forget to take a dose of DIOFLOX SUSPENSION?

A: If you forget to take a dose of DIOFLOX SUSPENSION, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take the medicine twice to make up for a forgotten dose.

Q: Can DIOFLOX SUSPENSION be stopped?

A: Continue taking DIOFLOX SUSPENSION until your doctor tells you to stop, unless you experience any unwanted effects, worsening of your condition or any new symptoms. In such a case, contact your doctor right away.

Q: Can I take other medicines with DIOFLOX SUSPENSION?

A: Before taking DIOFLOX SUSPENSION, inform your doctor if you are taking, have taken or might take any other medicine, including prescription, non-prescription or any herbal medicine, as these might interact with each other and cause serious side effects.

Q: Can DIOFLOX SUSPENSION cause nausea?

A: Yes. If you feel nauseous, take DIOFLOX SUSPENSION with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. If nausea does not improve, contact your doctor.

Q: Can I drive a car after taking DIOFLOX SUSPENSION?

A: Do not drive if you experience dizziness after taking DIOFLOX SUSPENSION. Consult your doctor if you feel any side effects during treatment with DIOFLOX SUSPENSION that may stop you from driving or using machines.

REFERENCES

1. K D Tripathi. Sulfonamides, Cotrimoxazole and Quinolones. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 713.

2. Derrick B. Graham; Jayson Tripp. Ofloxacin. StatPearls [Internet]. StatPearls Publishing. March 2022. [Accessed on 13th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK549837/

3. Shin YJ, Choi JS, Chung JH, Han JY, Ahn HK, Ryu HM. Pregnancy outcomes in women reporting exposure to ofloxacin in early pregnancy. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. August 2018. [Accessed on 13th July 2022] https://pubmed.ncbi.nlm.nih.gov/29565187/#:~:text=Ofloxacin%20and%20other%20quinolones%20are,of%20concerns%20about%20cartilage%20toxicity.

4. Drugs and Lactation Database (LactMed). Ofloxacin. NIH National Library of Medicine, National center for biotechnology information. [Revised in February 2021] [Accessed on 13th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK501055/#:~:text=Use%20of%20ofloxacin%20is%20acceptable,infant%20to%20ofloxacin%20in%20breastmilk.

5. Fostini R, Girelli M, Dalle Vedove P, Benedetti M, Recchia G. Safety profile of ofloxacin in elderly patients. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 1988. [Accessed on 13th July 2022] https://pubmed.ncbi.nlm.nih.gov/3063474/

6. Ishaq M, Farooqui BJ, Ashfaq MK, Khan MA. Therapeutic implications of ofloxacin in the treatment of typhoid fever caused by multiply resistant Salmonella typhi. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. August 1990. [Accessed on 13th July 2022] https://pubmed.ncbi.nlm.nih.gov/2126297/#:~:text=We%20concluded%20that%20ofloxacin%20can,to%20chloramphenicol%2C%20ampicillin%20and%20cotrimoxazole.

7. Elkos Healthcare. Ofloxacin. [Accessed on 13th July 2022] https://www.elkosgroup.in/product-details.php?name=OFLOKOS-100,  https://www.elkosgroup.in/product-details.php?name=OFLOKOS-50

USEFUL DIAGNOSTIC TESTS

• Bacterial culture
• Microscopic examination
• Completed Blood Count (CBC)

AUTHOR DETAILS

Written By Dr. Dhivakaran R, BDS
Last updated on 06 Jan 2023 | 12:30 PM(IST)