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INTRODUCTION
DIOFLOX M SUSPENSION is a combination of Metronidazole and Ofloxacin, which belong to the group of medicines called Antibiotics. DIOFLOX M SUSPENSION is used to treat different kinds of bacterial and parasitic infections (caused by different kinds of bacteria or parasites), diarrhea (loose, watery stools that occur more often than usual) and systemic infection (an infection that is in the bloodstream).
DIOFLOX M SUSPENSION should be used with caution in patients with liver problems, kidney problems and heart disease. DIOFLOX M SUSPENSION is not recommended for use by pregnant or breastfeeding women. Consult your doctor before taking it.
The most common side effects of DIOFLOX M SUSPENSION are nausea, headache, sleeplessness, genital itching in women, dizziness, vaginal inflammation, diarrhoea and vomiting. Consult your doctor if any of the symptoms worsen.
USES OF DIOFLOX M SUSPENSION
- Treats bacterial and parasitic infections
- Treats diarrhea
- Treats systemic infection (an infection that is in the bloodstream)
HOW DIOFLOX M SUSPENSION WORKS
DIOFLOX M SUSPENSION helps to reduce infections caused by different bacteria or parasites, whereas Metronidazole works by inhibiting the protein synthesis in the cells of various bacteria and parasites, which gradually leads to cell death. Ofloxacin works by preventing bacterial growth (DNA replication), which leads to cell death.
DIRECTIONS FOR USE
Always use DIOFLOX M SUSPENSION as directed by your physician. Shake well before use. Do not stop using DIOFLOX M SUSPENSION without informing your doctor.
SIDE EFFECTS OF DIOFLOX M SUSPENSION
COMMON
- nausea
- headache
- sleeplessness
- genital itching in women
- dizziness
- vaginal inflammation
- diarrhoea
- vomiting
RARE
Stop using DIOFLOX M SUSPENSION and contact your doctor immediately if you have:
- allergic reaction with symptoms such as swelling of the face, lips, throat or tongue, itching, difficulty breathing, difficulty swallowing
- skin rashes with blistering, peeling or bleeding of the skin around the lips, eyes, mouth, nose and genitals
- serious but very rare side effect is a brain disease (encephalopathy)
- blistering or bleeding of the skin around the eyes, mouth, lips, nose and genitals
- red, scaly widespread rash with bumps under the skin and blisters accompanied by fever
- steven johnson syndrome - severe blistering rash where layers of the skin may peel off
HOW TO MANAGE SIDE EFFECTS
Nausea / Vomiting:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods. Consult your doctor if the symptom does not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume alcohol. Consult your doctor if the symptom does not improve.
Dizziness:
If you feel dizzy, keep your eyes closed sit or lie down. Do not drive or operate machinery. Consult your doctor if the symptom does not improve.
Diarrhea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhoea. Consult your doctor if the symptom does not improve.
WARNING & PRECAUTIONS
PREGNANCY
DIOFLOX M SUSPENSION is not recommended for use in pregnant women. Consult your doctor before using it.
BREASTFEEDING
DIOFLOX M SUSPENSION is not recommended for use in breastfeeding women. Consult your doctor before using it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel sleepy or dizzy or could affect your eyesight after using DIOFLOX M SUSPENSION. Consult your doctor before using it.
ALCOHOL
Avoid consumption of alcohol while taking DIOFLOX M SUSPENSION because it might cause unpleasant side effects such as nausea, vomiting, hot flushes, stomach pain, very fast or uneven heartbeat and headache. Consult your doctor before using it.
KIDNEY
DIOFLOX M SUSPENSION should be used with caution in patients with kidney problems and patients undergoing kidney dialysis. Consult your doctor before using it.
LIVER
DIOFLOX M SUSPENSION should be used with caution in patients with liver problems. Consult your doctor before using it.
ALLERGY
Do not take DIOFLOX M SUSPENSION if you are allergic to metronidazole, ofloxacin, other quinolone antibiotics such as ciprofloxacin or norfloxacin or any of the other ingredients in this medicine. Consult your doctor before using it.
LUNGS
DIOFLOX M SUSPENSION should be used with caution in patients with a lung transplant. Consult your doctor before using it.
HEART DISEASE
DIOFLOX M SUSPENSION should be used with caution in patients with heart disease. Consult your doctor before using it.
OTHERS
Before using DIOFLOX M SUSPENSION, inform your doctor if you:
- have a disease of the nervous system
- are on hemodialysis
- have a history of joint problems or rheumatoid arthritis
- are suffering from Alzheimer’s disease, seizures, stroke
- have decreased in blood minerals
Use in Pediatrics:
DIOFLOX M SUSPENSION should be used with caution in children. Consult your doctor before using it.
Use in Geriatrics:
DIOFLOX M SUSPENSION should be used with caution. Consult your doctor before using it.
INTERACTIONS
A. Drug-Drug interactions:
Before taking DIOFLOX M SUSPENSION, inform your doctor if you are taking any of these medicines:
- warfarin (anticoagulants)
- lithium (used to treat mental illness)
- phenytoin, carbamazepine, phenobarbitone (used to treat epilepsy)
- 5 fluorouracil, busulfan (used to treat cancer)
- ciclosporin (immunosuppressant)
- disulfiram
Overdosage:
If you or anyone else accidentally receive too much of DIOFLOX M SUSPENSION, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Metronidazole, Ofloxacin |
| Pharmacological Category | : | Nitroimidazole antibiotic, Quinolone antibiotic |
| Therapeutic Indication | : | Bacterial and parasitic infections, diarrhea, systemic infection |
| Dosage Forms | : | Tablet, Syrup, Suspension, Oral Suspension |
MORE INFORMATION
- Keep DIOFLOX M SUSPENSION out of reach from children
- Store at room temperature
FAQs ABOUT DIOFLOX M SUSPENSION
Can I drive after taking DIOFLOX M SUSPENSION?
Do not drive or operate any machines if you feel sleepy or dizzy or if it could affect your eyesight after taking DIOFLOX M SUSPENSION. Since DIOFLOX M SUSPENSION is an antibiotic, it will affect the body’s normal functioning. So, it is advised not to drive or operate any machinery after taking DIOFLOX M SUSPENSION.
Can breast-feeding women take DIOFLOX M SUSPENSION?
A few clinical trial studies show that DIOFLOX M SUSPENSION passes through the breast milk from mother to infant while breastfeeding. So, DIOFLOX M SUSPENSION is not recommended for breastfeeding women. Consult your doctor before taking it.
I am presently undergoing kidney dialysis. Can I take DIOFLOX M SUSPENSION?
DIOFLOX M SUSPENSION should be used with caution in dialysis patients. Since dialysis purifies intoxicants and other materials in the blood, DIOFLOX M SUSPENSION can also be removed. So, the effect of DIOFLOX M SUSPENSION might be reduced. It is better to inform your doctor if you are on dialysis and you are taking DIOFLOX M SUSPENSION.
Does DIOFLOX M SUSPENSION cause vomiting?
Since vomiting is the most common side effect observed for DIOFLOX M SUSPENSION, it may cause vomiting. So, eat simple meals and avoid oily or spicy foods and take this medicine with or just after meals. Consult your doctor if the symptom does not improve.
How many doses of DIOFLOX M SUSPENSION can I take in a day?
Take DIOFLOX M SUSPENSION as advised by your physician. Do not crush or chew the medicine. Swallow the medicine with a glass of water. Your doctor will determine the correct dose and duration for you depending on your age, body weight and disease condition.
Does DIOFLOX M SUSPENSION cause sleeplessness?
Yes, the use of DIOFLOX M SUSPENSION may cause sleeplessness. DIOFLOX M SUSPENSION may influence the normal sleep cycle, resulting in reduced sleep compared to normal. So, it is better to make your surroundings comfortable, which can have a positive influence on sleep (like the room light being dimmed or minimizing external noises).
REFERENCES
1. KD Tripathi, Anti-microbial drugs and Beta-lactam Antibiotics, Essentials of medical pharmacology, Seventh edition. 2013 Page 894 & 713.
2. Connor B. Weir; Jacqueline K. Le., Metronidazole, National Library of Medicine. [Revised April 2022] [Accessed 22 June 2022] https://www.ncbi.nlm.nih.gov/books/NBK539728/
3. JB Chemicals, OFM SUSP, CIMS. [Accessed 22 June 2022] https://www.mims.com/india/drug/info/ofm%20susp
4. Rosemont, Metronidazole. [Revised April 2020] [Accessed 22 June 2022] https://www.medicines.org.uk/emc/files/pil.6690.pdf
5. Medindia, Ofloxacin. [Accessed 22 June 2022] https://www.medindia.net/drug-price/ofloxacin/zo-60ml.htm#Indication
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