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INTRODUCTION
DIANORM M OD 1000 is a combination of Gliclazide and Metformin which belongs to a group of medicines called Antidiabetic agents. DIANORM M OD 1000 is used to treat type 2 diabetes mellitus when diet, exercise and single therapy does not result in adequate glycemic control. Type 2 diabetes is a chronic medical condition in which the body does not make enough insulin, or the produced insulin does not work well. Symptoms include excessive urination, excessive thirst, hunger, fatigue, and blurred vision.
Gliclazide increases the release of insulin from the functioning of pancreatic beta cells to lower the blood glucose. Metformin is a biguanide which effectively reduces the total amount of sugar released into the blood by the liver. Along treatment with DIANORM M OD 1000 follow regular exercise and diet plan as advised by your doctor to achieve better results.
Before taking DIANORM M OD 1000 inform your doctor if you have type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney diseases, heart failure. DIANORM M OD 1000 is not recommended for use in pregnant or breastfeeding women. It is not recommended for use in children and adolescents less than 18 years of age. Avoid consumption of alcohol during treatment with DIANORM M OD 1000 as it may increase the risk of lactic acidosis and low blood sugar levels. The most common side effects of taking DIANORM M OD 1000 are low blood sugar (hypoglycemia), taste disturbance, nausea, diarrhea, stomach pain and vomiting. Contact your doctor if any of the symptoms worsen.
USES OF DIANORM M OD 1000
- Treats type 2 diabetes mellitus (when diet, exercise and single therapy does not result in adequate glycemic control)
HOW DIANORM M OD 1000 WORKS
DIANORM M OD 1000 controls blood glucose levels, where gliclazide works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin works by lowering glucose production in the liver, delaying glucose absorption from intestines, and increasing the body's sensitivity to insulin.
DIRECTIONS FOR USE
Take DIANORM M OD 1000 as advised by your physician. Swallow DIANORM M OD 1000 with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age and disease condition. Do not stop taking DIANORM M OD 1000 without informing your doctor.
SIDE EFFECTS OF DIANORM M OD 1000
COMMON
- nausea, vomiting
- diarrhoea
- stomach pain
- loss of appetite
- taste disturbance
- low blood sugar
RARE
- signs of reduced number of red blood cells (skin pale and weakness or breathlessness), platelets (easy bleeding or bruising) or white blood cells (repeated infections)
- cholestatic jaundice appears
- skin and subcutaneous tissue disorders (skin rash, itching, angioedema, bullous reactions)
- visual disturbances
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.
Stomach pain:
Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.
Loss of appetite:
Eat when you feel hungry. Eat smaller meals frequently than usual. Snack only when you're hungry. Consult your doctor if the symptom did not improve.
Nausea and vomiting:
Stick to simple meals. Avoid eating oily, fried, and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
DIANORM M OD 1000 is not recommended for use during pregnancy. Consult your doctor before taking DIANORM M OD 1000 if you are pregnant or planning to get pregnant.
BREASTFEEDING
DIANORM M OD 1000 is not recommended for use in breast-feeding women. Consult your doctor for advice.
DRIVING AND USING MACHINES
Do not drive or handle any machines if you experience low blood sugar levels (symptoms include dizziness, tiredness, or trembling). However, patients should be alerted to the risk of hypoglycemia (low blood sugar levels) before driving or using any machines. Consult your doctor before taking DIANORM M OD 1000.
ALCOHOL
Avoid consumption of alcohol while taking DIANORM M OD 1000 since it may increase the risk of lactic acidosis or low blood sugar levels (than can lead to onset of hypoglycemic coma).
KIDNEY
DIANORM M OD 1000 is not recommended for use in patients with moderate or severe kidney failure or impairment and it should be used with caution in patients with impaired kidney function. Consult your doctor before taking DIANORM M OD 1000.
LIVER
DIANORM M OD 1000 is not recommended for use in patients with liver insufficiency. Consult your doctor before taking DIANORM M OD 1000.
ALLERGY
Do not take DIANORM M OD 1000 if you are allergic (hypersensitive) to Gliclazide or Metformin.
LUNGS
DIANORM M OD 1000 is not recommended for use in patients with respiratory failure. Consult your doctor before taking DIANORM M OD 1000.
HEART DISEASE
DIANORM M OD 1000 is not recommended for use in patients with decompensated heart failure, recent heart attack or shock. Consult your doctor before taking DIANORM M OD 1000.
OTHERS
DIANORM M OD 1000 is not recommended for use if you have:
- diabetic ketoacidosis, diabetic pre-coma
- dehydration, severe infection, or shock
- rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption
- are undergoing surgery
- severe trauma or infections
- peripheral vascular disease
Before taking DIANORM M OD 1000 inform your doctor if you:
- have glucose-6-phosphate dehydrogenase (G6PD) deficiency
- poorly controlled diabetes, prolonged fasting, ketosis (to avoid risk of lactic acidosis)
- have thyroid disorders, hypopituitarism or adrenal insufficiency, imbalance between physical exercise and carbohydrate intake, malnutrition, irregular mealtimes, skipping meals or dietary changes (to avoid risk of low blood sugar levels)
Use in pediatrics:
DIANORM M OD 1000 is generally not recommended for use in children and adolescents (under 18 years of age) due to lack of safety and effectiveness. Consult child’s doctor for advice.
Use in geriatrics:
DIANORM M OD 1000 should be used with caution in elderly patients (aged 65 years or above), especially in patients with impaired kidney function. Your doctor may adjust the dose depending upon kidney function and your kidney function will be monitored regularly throughout the treatment. Consult your doctor before taking DIANORM M OD 1000.
INTERACTIONS
A. Drug-Drug interactions:
Before taking DIANORM M OD 1000 inform to your doctor, if you are taking any of these medicines:
- beta-blockers such as metoprolol, atenolol, angiotensin converting enzyme inhibitors such as captopril, enalapril (treats high blood pressure)
- warfarin (treats blood clot)
- phenylbutazone (treats pain and inflammation)
- miconazole, fluconazole (used to treat fungal infections)
- insulins, acarbose, thiazolidinediones (Ex. rosiglitazone), dipeptidyl peptidase-4 inhibitors (Ex. linagliptin), GLP-1 receptor agonists (Ex. Semaglutide) (treats high blood sugar)
- glucocorticoids (Ex. dexamethasone, prednisolone) (used to treat inflammation)
- monoamine oxidase inhibitors (MAOIs) such as phenelzine, selegiline (treats mental disorders)
- sulfonamides such as sulfamethoxazole, clarithromycin (treats bacterial infection)
- danazol (treats endometriosis)
- chlorpromazine (used to treat psychotic disorders)
- ritodrine (used to stop premature labor)
- salbutamol, terbutaline (used to treat asthma)
- H2-receptor antagonists such as cimetidine, famotidine (used to treat ulcers)
- nonsteroidal anti-inflammatory agents (Ex. aspirin, ibuprofen) (used to treat pain)
Overdosage:
If you or anyone else take too much of DIANORM M OD 1000, contact your doctor immediately or go to a nearest hospital straight away. Overdosage of DIANORM M OD 1000 may cause lactic acidosis and low blood sugar levels (in severe cases it leads to coma, seizures, or neurological disorders).
SYNOPSIS
| Drug | : | Gliclazide, Metformin |
| Pharmacological Category | : | Antidiabetic agents |
| Therapeutic Indication | : | Type 2 Diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep DIANORM M OD 1000 out of reach of children
- Store at temperature below 25°C
FAQs ABOUT DIANORM M OD 1000
What is DIANORM M OD 1000 used for?
DIANORM M OD 1000 is used to treat type 2 diabetes mellitus when diet, exercise and single therapy alone does not result in adequate glycemic control. Along treatment with DIANORM M OD 1000 follow regular exercise and diet plan as advised by your doctor to achieve better results.
What are the common side effects of GBNKEYWORD]?
The most common side effects of taking DIANORM M OD 1000 are taste disturbance, nausea, vomiting, diarrhea, loss of appetite, and stomach pain. Contact your doctor if any of the symptoms worsen.
Can I consume alcohol while taking DIANORM M OD 1000?
Avoid consumption of alcohol during treatment with DIANORM M OD 1000 as it may increase the risk of lactic acidosis or low blood sugar levels (than can lead to onset of hypoglycemic coma). Consult your doctor for advice before taking DIANORM M OD 1000.
Can DIANORM M OD 1000 be used in children?
DIANORM M OD 1000 is generally not recommended for use in children and adolescents (under 18 years of age) due to lack of safety and effectiveness. Consult child’s doctor for advice.
Is DIANORM M OD 1000 safe to use in patients with kidney problems?
DIANORM M OD 1000 is not recommended for use in patients with moderate or severe kidney failure or impairment and it should be used with caution in patients with impaired kidney function. Consult your doctor before taking DIANORM M OD 1000.
REFERENCES
1. KD Tripathi MD. Hormones and related drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 274.
2. Anil Pareek, Nitin Chandurkar, Shyamsundar Zawar, Navneet Agrawal. Evaluation of efficacy and tolerability of gliclazide and metformin combination: a multicentric study in patients with type 2 diabetes mellitus uncontrolled on monotherapy with sulfonylurea or metformin. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. December 2010. [Accessed on 24th July 2021] https://pubmed.ncbi.nlm.nih.gov/20093927/
3. Nareen Krishna Polavarapu, Ravindra Kale, Bipin Sethi, R. K. Sahay, Uday Phadke, Santosh Ramakrishnan, Amey Mane, Suyog Mehta, and Snehal Shah. Effect of Gliclazide or Gliclazide plus Metformin Combination on Glycemic Control in Patients with T2DM in India: A Real-World, Retrospective, Longitudinal, Observational Study from Electronic Medical Records. NCBI; PMC. Pubmed Central. US National Library of Medicine, National Institute of Health. July 2020. [Accessed on 24th July 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581661/
4. Windlas Biotech Ltd. Gliclazide and Metformin Hydrochloride (SR) Tablet. [Accessed on 24th July 2021] https://www.biocon.com/docs/prescribing_information/diabetology/zukermf_pi.pdf
5. Panacea Biotec Limited. Product Monograph. Gliclazide SR 60mg and Metformin SR 500mg / Gliclazide SR 30mg and Metformin SR 500mg Tablets. [Revised in September 2014] [Accessed on 24th July 2021] https://media.panaceabiotec.com/documents/2019/7/27/ProductMonograph-GlizidMODgliclazideSR30and60-MetforminSR500.pdf
6. Torrent pharmaceuticals Ltd. Azukon-M (Gliclazide and Metformin Tablets). [Revised in January 2016] [Accessed on 24th July 2021] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1995.pdf
USEFUL DIAGNOSTIC TESTS
- Glucose - Fasting Blood
- Glucose - Postprandial Blood
- Glycosylated Hemoglobin
VIDEOS
Gliclazide+Metformin Tablet - Drug Information
Gliclazide+Metformin Tablet : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
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