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Drug Information

What is Imipramine used for?

Imipramine is used for the treatment of depression. It is also prescribed to treat bed-wetting in children.

Imipramine may also be prescribed for other conditions as determined by the doctor.

How does Imipramine work?

Imipramine belongs to the class of drugs called tricyclic anti-depressants. This drug acts by producing chemical messengers in the brain such as serotonin and norepinephrine, which helps in treating depression symptoms.

Imipramine also works by blocking the action of acetylcholine in the urinary bladder and preventing bedwetting in children.

How to take Imipramine?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Take Imipramine as prescribed by your doctor.

Swallow the tablet whole. Do not crush or chew the tablet. In case of capsule swallow the capsule whole. Do not chew or tear open the capsule. Take the drug with or without food. However, taking the drug with food prevents stomach upset.

If you miss a dose of Imipramine, please take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

The overdose symptoms of Imipramine may include:

  • Cardiac arrest
  • Dizziness
  • Drowsiness
  • Hypotension
  • Increased reflex movements
  • Nausea
  • Restlessness

What are the drugs that interact with Imipramine?

Drugs that interact with Imipramine include the following:

  • Cimetidine
  • Phenobarbital
  • Quinidine
  • Secobarbital

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Imipramine?

The following are the most common side effects of Imipramine:

  • Drowsiness
  • Dizziness
  • Constipation
  • Nausea
  • Vomiting

The following are the severe side effects and you may require immediate medical attention:

  • Blurry vision
  • Cold sweats
  • Disorientation
  • Increased palpitations

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions Imipramine?

  • Do not drive or operate heavy machinery if Imipramine causes dizziness or blurred vision.
  • Inform the doctor if your child has suicidal tendencies, as Imipramine may increase the risk of suicidal thoughts.
  • Avoid consumption of alcohol as it may alter the absorption of Imipramine.
  • Avoid Imipramine during pregnancy or breastfeeding because the safe use of the drug is not yet established.
  • Do not stop using the medication abruptly unless instructed by the doctor. Stopping the medication suddenly may cause the illness to return.
  • Do not exceed the dose more than what is prescribed.

You are advised not to take Imipramine if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking Imipramine?

  • Tell your doctor if you have any history of sleeplessness and anxiety disorders.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.

Frequently Asked Questions about Imipramine

  1. My child is on Imipramine for bed-wetting. Can I stop giving the drug if my child feels better?
  2. Imipramine can be discontinued once your child stops bed-wetting. However, consult the doctor before discontinuing Imipramine medicine.

  3. How long can I take Imipramine medicine?
  4. Take Imipramine medicine as prescribed by the doctor. Prolonged use of the medicine is not advisable.

  5. Is it safe to alter the dose of Imipramine?
  6. Do not alter the dose of Imipramine without consulting the doctor. A change in the dose of the drug may be recommended depending on the response to the drug.

  7. Should I follow any special dietary instructions while taking Imipramine?
  8. Avoid consuming alcohol or the foods that may affect the brain function. Also, increase the intake of fiber foods, as the drug may cause constipation.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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