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DAYCLAZIDE TOTAL 60 Tablet 10's
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INTRODUCTION
DAYCLAZIDE TOTAL 60 TABLET is a combination of Gliclazide, Metformin and Pioglitazone which belongs to the group of medicines called Antidiabetic agents. It is used in adults to treat type II diabetes mellitus when diet, exercise and treatment with single agents does not result in adequate sugar control.
Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin.
Before taking DAYCLAZIDE TOTAL 60 TABLET, inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any eye problems, hormonal imbalance, alcoholism or if you are malnourished, starved, on an irregular diet as a precaution.
DAYCLAZIDE TOTAL 60 TABLET is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis. It is also not suitable for use in pregnant or breastfeeding women.
Along with the treatment, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking DAYCLAZIDE TOTAL 60 TABLET as it may aggravate your existing condition.
The most common side effects of taking DAYCLAZIDE TOTAL 60 TABLET are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness and weight gain. Consult your doctor if any of these side effect worsens.
USES OF DAYCLAZIDE TOTAL 60 TABLET
- Treats Type II diabetes mellitus
HOW DAYCLAZIDE TOTAL 60 TABLET WORKS
DAYCLAZIDE TOTAL 60 TABLET stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). It also makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, it can also reduce the glucose produced by the liver and reduces its absoprtion in the body.
DIRECTIONS FOR USE
Take DAYCLAZIDE TOTAL 60 TABLET preferably just before meals or during meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Do not stop taking DAYCLAZIDE TOTAL 60 TABLET unless your doctor advice you to stop.
SIDE EFFECTS OF DAYCLAZIDE TOTAL 60 TABLET
COMMON
- hypoglycemia (low blood sugar levels)
- nausea, vomiting
- diarrhea, stomach pain, loss of appetite, flatulence
- changes in taste, metallic taste
- headache, dizziness
- joint pain, back pain, muscle pain
- impotence
- respiratory infection, sinus infection, sore throat
- weight gain
UNCOMMON
- difficulty in sleeping (insomnia)
- proteins in urine
- spinning sensation (vertigo)
RARE
Stop taking DAYCLAZIDE TOTAL 60 TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
- symptoms of heart failure (such as unusual shortness of breath or trouble in breathing, rapid increase in weight or localised swelling (oedema), especially in the ankles or legs, unusual tiredness)
- signs and symptoms of bladder cancer (such as blood in your urine, pain while urinating or urgent need to pee)
- increased risk of fractures (especially in the bones of hand, upper arm or foot in women)
- blurred vision due to swelling at the back of the eye or worsening of existing blurred vision
- serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
- signs of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)
HOW TO MANAGE SIDE EFFECTS
Hypoglycemia:
Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack or a drink and check the blood sugar again. Consult your doctor if there is no improvement in your condition.
Diarrhea:
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.
Nausea:
Take DAYCLAZIDE TOTAL 60 TABLET with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol. Consult your doctor if your dizziness worsens.
WARNING & PRECAUTIONS
PREGNANCY
DAYCLAZIDE TOTAL 60 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.
BREASTFEEDING
DAYCLAZIDE TOTAL 60 TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if your ability is affected by DAYCLAZIDE TOTAL 60 TABLET.
ALCOHOL
Avoid consumption of alcohol while taking DAYCLAZIDE TOTAL 60 TABLET as it may increase the risk of unwanted side effects.
KIDNEY
GBNKEYWORD] is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
LIVER
GBNKEYWORD] is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
ALLERGY
Do not take DAYCLAZIDE TOTAL 60 TABLET if you are allergic to Gliclazide, Metformin, Pioglitazone or to any other sulfonylureas (Ex. glyburide, glimepiride) or sulphonamides (Ex. sulfasalazine).
LUNGS
DAYCLAZIDE TOTAL 60 TABLET is not recommended for use in patients with breathing problems (such as asthma or COPD). Therefore, consult your doctor before taking it.
HEART DISEASE
DAYCLAZIDE TOTAL 60 TABLET is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems. Therefore, consult your doctor before taking it.
OTHERS
DAYCLAZIDE TOTAL 60 TABLET is not recommended for use if you:
- have type I diabetes mellitus (insulin dependent diabetes)
- have lactic acidosis (build-up of lactic acid in the body)
- have diabetic ketoacidosis (a diabetic complication causing episodes of fatigue, nausea, frequent urination and muscular stiffness)
- have bladder cancer
- pass bloody urine
- are scheduled for any surgery
- recently met with any accident
- have any serious infection
Before taking DAYCLAZIDE TOTAL 60 TABLET, inform your doctor if you:
- are recovering from any injury, operation, infections or from any form of stress
- have G6PD deficiency
- are on fating or malnourished, starved, on an irregular diet or feeling weak
- perform extreme physical exercises without proper carbohydrate intake
- are severely dehydrated
- have hormonal problems (Ex. disorders of pituitary gland, adrenal cortex or thyroid gland)
- are an alcoholic
- have edema (swelling of body parts)
- smoke
- have special type of diabetic eye disease called macular oedema (swelling of the back of the eye with worsening of your vision)
- have cysts on your ovaries (polycystic ovarian syndrome)
- previously had stroke
- have anemia (low RBC in blood)
- have any bone problems or at risk of developing bone fractures
- are a premenopausal woman
- have thyroid problems
Use in Pediatrics:
DAYCLAZIDE TOTAL 60 TABLET is not recommended for use in children and in adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use in Geriatrics:
DAYCLAZIDE TOTAL 60 TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug Interactions:
Before taking DAYCLAZIDE TOTAL 60 TABLET, inform your doctor if you are taking any of the following medicines:
- other medicines used to treat diabetes mellitus (such as teneligliptin, rosiglitazone, insulin, glimepiride)
- medicines used for treating pain and inflammation (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azopropazone, oxyphenbutazone)
- medicines used to treat urinary infections (amikacin, nitrofurantoin, sulfamethoxazole)
- medicines used to treat bacterial infections (such as tetracyclines, chloramphenicol, ciprofloxacin, clarithromycin)
- medicines used to treat fungal infection (Ex. fluconazole, miconazole, isuvaconazole)
- medicines used for male sex hormone replacement therapy (Ex. testosterone)
- medicines used to treat depression (such as moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine, St.John’s Wort)
- medicines used to treat stomach ulcers (such as ranitidine, famotidine)
- medicines used to treat high blood cholesterol levels (Ex. fenofibrate, nicotinic acid, colesevelam)
- medicines used to treat high blood pressure (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine and reserpine)
- medicines used to treat cancer (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib and olaparib)
- medicines used to treat allergic rhinitis (Ex. tritoqualine)
- hormonal replacement therapy (used to treat menstrual disorders in women) Ex. estradiol
- thiazide diuretics (used to treat edema and high blood pressure) Ex. hydrochlorothiazide
- medicines to treat mental illness (such as chlorpromazine, prochlorperazine, lithium)
- corticosteroids (used to treat pain and inflammation) Ex. prednisolone, betamethasone
- medicines used to treat asthma (Ex. salbutamol, terbutaline)
- medicines used to treat epilepsy (Ex. phenytoin)
- cimetidine (a medicine used to treat stomach ulcers)
- rifampicin (a medicine used to treat tuberculosis)
- dolutegravir (a medicine used to treat HIV infection)
- ranolazine (a medicine used to treat chest pain)
- trimethoprim (a medicine used to treat bacterial infection)
- ritodrine (a medicine used to stop premature labour)
Overdosage:
If you or anyone else accidentally took more DAYCLAZIDE TOTAL 60 TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion). To manage this, consume any sugary food immediately. If the symptom did not improve or worsens contact your doctor immediately. Other symptoms of overdosage might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.
SYNOPSIS
| Drug | : | Gliclazide, Metformin, Pioglitazone |
| Pharmacological Category | : | Sulfonylureas, Biguanides, PPAR-gamma and PPAR-alpha agonists |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep DAYCLAZIDE TOTAL 60 TABLET out of reach of children
- Store DAYCLAZIDE TOTAL 60 TABLET at room temperature
FAQs ABOUT DAYCLAZIDE TOTAL 60 TABLET
Q: What is DAYCLAZIDE TOTAL 60 TABLET used for?
A: DAYCLAZIDE TOTAL 60 TABLET is an antidiabetic medicine used to treat Type II diabetes mellitus when diet, exercise and treatment with single agents does not result in adequate response.
Q: How and when to take DAYCLAZIDE TOTAL 60 TABLET?
A: Take DAYCLAZIDE TOTAL 60 TABLET preferably just before meals or during meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: How long should I take DAYCLAZIDE TOTAL 60 TABLET?
A: You need to take DAYCLAZIDE TOTAL 60 TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
Q: What is the best time to take DAYCLAZIDE TOTAL 60 TABLET?
A: DAYCLAZIDE TOTAL 60 TABLET must be taken just before meals or during meals to avoid gastrointestinal side effects.
Q: What to do if I forgot to take a dose of DAYCLAZIDE TOTAL 60 TABLET?
A: If you forgot to take a dose of DAYCLAZIDE TOTAL 60 TABLET, take it as soon as you remember. However, if it is time for the next dose of DAYCLAZIDE TOTAL 60 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of DAYCLAZIDE TOTAL 60 TABLET to compensate the missed ones.
Q: Can I stop taking DAYCLAZIDE TOTAL 60 TABLET without consulting your doctor?
A: No. You should not stop taking DAYCLAZIDE TOTAL 60 TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using DAYCLAZIDE TOTAL 60 TABLET, consult your doctor for advice.
Q: Will taking a higher dose of DAYCLAZIDE TOTAL 60 TABLET be more effective?
A: No, taking a higher dose of DAYCLAZIDE TOTAL 60 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I take medication for high blood pressure along with DAYCLAZIDE TOTAL 60 TABLET?
A: It is not advisable to take medicines to control blood pressure while taking DAYCLAZIDE TOTAL 60 TABLET without consulting your doctor, as they have known interactions with DAYCLAZIDE TOTAL 60 TABLET.
Q: How to manage the side effects of DAYCLAZIDE TOTAL 60 TABLET?
A: Low blood sugar is a common side effect of taking DAYCLAZIDE TOTAL 60 TABLET. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey or sugary candy. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack or drink and check the blood sugar levels once again. If your condition did not improve, consult your doctor immediately.
Q: Can DAYCLAZIDE TOTAL 60 TABLET be taken with insulin?
A: Co-administration of DAYCLAZIDE TOTAL 60 TABLET with insulin is considered risky as they can increase the chances of hypoglycemia (low blood sugar levels). Therefore, consult your doctor before taking it.
Q: Can DAYCLAZIDE TOTAL 60 TABLET be used in pregnant women?
A: DAYCLAZIDE TOTAL 60 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking it.
Q: Does DAYCLAZIDE TOTAL 60 TABLET cause bone fractures?
A: DAYCLAZIDE TOTAL 60 TABLET may cause bone fractures in some individuals. Therefore, it is important for you to inform your doctor before taking DAYCLAZIDE TOTAL 60 TABLET if you have any bone problems or at risk of developing any bone fractures (such as menopause).
Q: Does DAYCLAZIDE TOTAL 60 TABLET cause weight gain?
A: Yes. DAYCLAZIDE TOTAL 60 TABLET may cause weight gain in some individuals. To avoid this, follow a healthy diet and regular physical activity as advised by your physician. However, if you experience any weight gain due to swelling of body parts (such as in face, legs or hands), consult your doctor immediately.
Q: What are the side effects of taking DAYCLAZIDE TOTAL 60 TABLET?
A: The most common side effects of taking DAYCLAZIDE TOTAL 60 TABLET are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness and weight gain. Consult your doctor if any of these side effect worsens.
REFERENCES
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270, 275 & 276.
2. Glyn Belcher, Ceri Lambert, Gareth Edwards, Richard Urquhart, David R Matthews. Safety and tolerability of pioglitazone, metformin and gliclazide in the treatment of type 2 diabetes. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. October 2005. [Accessed on 17th January 2023]. https://pubmed.ncbi.nlm.nih.gov/16002175/
3. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 17th January 2023]. https://www.medicines.org.uk/emc/files/pil.594.pdf
4. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 17th January 2023]. https://www.medicines.org.uk/emc/files/pil.11951.pdf
5. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2020] [Accessed on 17th January 2023] https://www.medicines.org.uk/emc/files/pil.8836.pdf
6. Les Laboratories Servier Industrie. Gliclazide. Diamicron 30mg MR Tablet. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 17th January 2023]. https://www.medicines.org.uk/emc/files/pil.1321.pdf
7. Milpharm Limited. Gliclazide 80mg Tablets. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 17th January 2023]. https://www.medicines.org.uk/emc/files/pil.7023.pdf
8. Brown & Burk UK Ltd. Gliclazide 40 mg Tablets. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 17th January 2023]. https://www.medicines.org.uk/emc/files/pil.13135.pdf
9. Panacea Biotec Limited. Glizid Total P 15. Gliclazide SR 60mg + Metformin SR 500mg + Pioglitazone 15mg. [Revised in July 2019]. [Accessed on 17th January 2023]. https://media.panaceabiotec.com/documents/2019/7/27/ProductMonograph-GlizidTotalP15.pdf
10. Central Drugs Standard Control Organization. Metformin SR 500mg/500mg + GliclazideSR 60mg/30mg + Pioglitazone 15mg/15mg tablets. May 2010. [Accessed on 17th January 2023]. https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
USEFUL DIAGNOSTIC TESTS
- Glucose - Fasting Blood
- Glucose - Postprandial Blood
- Glycosylated Haemoglobin
AUTHOR DETAILS
Written By Srilekha. R, B.Pharm
Last updated on 17 Jan 2023 | 06:46 PM(IST)
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