DASLEMIA 70 Tablet 60's

INTRODUCTION

DASLEMIA 70 TABLET contains Dasatinib which belongs to the group of medicines called Tyrosine Kinase Inhibitor. It is used to treat cancers of blood and bone marrow (such as chronic myeloid leukaemia (CML) or Philadelphia chromosome positive (Ph+) acute lymphoblastic leukaemia) in adults, adolescents and in children (aged 1 year or above).

It is primarily used in patients when treatment with conventional therapies is not suitable or fails to provide adequate response.

Leukaemia is the cancer of blood cells. It is caused due to abnormal growth and multiplication of blood cells within the bone marrow. It is characterized by severe tiredness, breathlessness, increased bleeding tendency, tiredness, anemia, night sweats, fever, chills, frequent infections and weight loss.

During treatment with DASLEMIA 70 TABLET your doctor will closely monitor your health condition through several blood tests to avoid the risk of unwanted side effects. Avoid eating grapefruit or drinking grapefruit juice while taking DASLEMIA 70 TABLET as it may increase the risk of side effects.

Before taking DASLEMIA 70 TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have or at risk of developing hepatitis C infection as a precaution.

Avoid concomitant use of antacids or any stomach medicines along with DASLEMIA 70 TABLET. Leave a time gap of at least 2 hours between the medicines. DASLEMIA 70 TABLET is not recommended for use in pregnant or breastfeeding women.

Men and women taking DASLEMIA 70 TABLET must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with DASLEMIA 70 TABLET.

The most common side effects of taking DASLEMIA 70 TABLET are increased bleeding tendency, increased infections, feeling tired or weak, nausea, vomiting, hair loss, mouth ulcers, changes in taste, inflammation of the food pipe or stomach, muscle pain or spasm, skin rashes, headache, dizziness and weight loss. Contact your doctor if any of these side effect worsens.

USES OF DASLEMIA 70 TABLET

It is used in adults, adolescents and in children (aged 1 year or above) to treat:

• Cancers of blood and Bone marrow (such as chronic myeloid leukaemia or (Ph+) acute lymphoblastic leukaemia)

HOW DASLEMIA 70 TABLET WORKS

DASLEMIA 70 TABLET is an anti-cancer medicine. It works by blocking the actions of certain proteins (such as BCR-ABL, Src kinase, etc.) in the body that triggers cancer formation. As a result, it reduces abnormal growth and multiplication of cancer cells in the body.

DIRECTIONS FOR USE

Take DASLEMIA 70 TABLET as advised by your physician. It can be taken with or without meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Try to take DASLEMIA 70 TABLET at the same time each day. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking DASLEMIA 70 TABLET unless advised by your doctor.

SIDE EFFECTS OF DASLEMIA 70 TABLET

HOW TO MANAGE SIDE EFFECTS

Skin rash:

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.

Nausea and Vomiting:

Stick to simple meals. Avoid eating oil rich or spicy foods. If your nausea worsens, consult your doctor for advice.

Mouth ulcers:

Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.

Diarrhoea:

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.

Constipation:

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatments for constipation.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions:

Before taking DASLEMIA 70 TABLET, inform your doctor, if you are taking any of the following medicines such as:

• medicines used for blood thinning (Ex. warfarin)
• ketoconazole, itraconazole (used to treat fungal infection)
• medicines used to treat bacterial infection (such as erythromycin, clarithromycin, telithromycin)
• ritonavir (a medicine used to treat HIV infection)
• medicines used to treat epilepsy (Ex. phenytoin, carbamazepine, phenobarbital)
• rifampicin (a medicine used to treat tuberculosis)
• medicines used to treat stomach ulcers (such as famotidine, omeprazole)
• St. John’s wort (an herbal preparation used to treat depression)
• antacids (used to neutralize stomach acids) Ex. aluminium hydroxide or magnesium hydroxide

B. Drug-Food Interactions:

Avoid eating grapefruit or drinking grapefruit juice while taking DASLEMIA 70 TABLET as it may increase the risk of side effects.

Overdosage:

If you or anyone else accidentally took more DASLEMIA 70 TABLET, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

Drug	:	Dasatinib
Pharmacological Category	:	BCR-ABL Tyrosine Kinase Inhibitor
Therapeutic Indication	:	Chronic Myeloid Leukaemia, Acute Lymphoblastic Leukaemia
Dosage Forms	:	Tablet

MORE INFORMATION

• Keep DASLEMIA 70 TABLET out of reach of children
• Store DASLEMIA 70 TABLET at room temperature

FAQs ABOUT DASLEMIA 70 TABLET

What DASLEMIA 70 TABLET is used for?

DASLEMIA 70 TABLET is used to treat cancers of blood and bone marrow (such as chronic myeloid leukaemia (CML) or Philadelphia chromosome positive (Ph+) acute lymphoblastic leukaemia) in adults, adolescents and in children (aged 1 year or above). It is primarily used in patients when treatment with conventional therapies is not suitable or fails to provide adequate response.

How DASLEMIA 70 TABLET works on my body?

DASLEMIA 70 TABLET is an anti-cancer medicine. It works by blocking the actions of certain proteins (such as BCR-ABL, Src kinase, etc.) in the body that triggers cancer formation. As a result, it reduces abnormal growth and multiplication of cancer cells in the body.

Can DASLEMIA 70 TABLET cure cancer?

The cure rate of cancer depends upon the severity of the disease. However, DASLEMIA 70 TABLET acts by preventing the abnormal growth and multiplication of cancer cells in the body, which may help in curing cancer completely.

Can the use of DASLEMIA 70 TABLET cause hair loss?

Hair loss is one of the common side effects of taking DASLEMIA 70 TABLET. If it bothers you, consult your doctor for advice.

Can the use of DASLEMIA 70 TABLET cause mouth ulcers?

Mouth ulcers are one of the common side effects of taking DASLEMIA 70 TABLET. Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.

Can DASLEMIA 70 TABLET be used in children?

DASLEMIA 70 TABLET can be used in children and adolescents (aged 1 year or above) if prescribed by the physician. It should not be used in children aged below 1 year due to increased risk of side effects.

Is DASLEMIA 70 TABLET a chemo drug?

Yes. DASLEMIA 70 TABLET contains a medicine called Dasatinib which is a chemotherapeutic agent. It stops abnormal growth and multiplication of cancer cells in the body.

What happens if I forgot to take a dose of DASLEMIA 70 TABLET?

If you forgot to take a dose of DASLEMIA 70 TABLET, take it as soon as you remember. However, if it is time for the next dose of DASLEMIA 70 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of DASLEMIA 70 TABLET to compensate the missed ones.

What precautions must be followed while taking DASLEMIA 70 TABLET?

Before taking DASLEMIA 70 TABLET inform your doctor if you have any liver, kidney or heart problems or if you have or at risk of developing hepatitis C infection as a precaution. Avoid eating grapefruit or drinking grapefruit juice while taking DASLEMIA 70 TABLET. Leave a time gap of at least 2 hours between DASLEMIA 70 TABLET and stomach medicines. Inform your doctor before taking DASLEMIA 70 TABLET if you are pregnant or breastfeeding women. Men and women taking DASLEMIA 70 TABLET must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with DASLEMIA 70 TABLET.

Will taking a higher dose of DASLEMIA 70 TABLET be more effective?

No, taking a higher dose of DASLEMIA 70 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

What happens if I stop taking DASLEMIA 70 TABLET?

No. Do not stop taking DASLEMIA 70 TABLET without consulting your doctor as it may make your symptoms reappear. Therefore, take DASLEMIA 70 TABLET as advised by your doctor for the stipulated duration.

Can DASLEMIA 70 TABLET be used during pregnancy?

DASLEMIA 70 TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, inform your doctor before taking DASLEMIA 70 TABLET if you are pregnant or think you may be pregnant.

Can the use of DASLEMIA 70 TABLET make me feel tired?

Yes. DASLEMIA 70 TABLET may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after taking DASLEMIA 70 TABLET. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while taking this medicine.

Can I drive a car after taking DASLEMIA 70 TABLET?

DASLEMIA 70 TABLET may make you feel tired or dizzy. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by DASLEMIA 70 TABLET.

How to take DASLEMIA 70 TABLET?

Take DASLEMIA 70 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. DASLEMIA 70 TABLET can be taken with or without food.

How to control nausea caused due to DASLEMIA 70 TABLET?

Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with DASLEMIA 70 TABLET. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.

What are the side effects of taking DASLEMIA 70 TABLET?

The most common side effects of taking DASLEMIA 70 TABLET are increased bleeding tendency, increased infections, feeling tired or weak, nausea, vomiting, hair loss, mouth ulcers, changes in taste, inflammation of the food pipe or stomach, muscle pain or spasm, skin rashes, headache, dizziness and weight loss. Contact your doctor if any of these side effect worsens.

Who should avoid taking DASLEMIA 70 TABLET?

DASLEMIA 70 TABLET is not recommended for use if you are allergic to dasatinib. It is also not recommended for use in pregnant or breastfeeding women and in children (aged below 1 year).

Is DASLEMIA 70 TABLET safe to use in kidney disease?

DASLEMIA 70 TABLET should be used with caution in patients with kidney problems. Your doctor will access your health condition and suggest a suitable dose for you.

Can the use of DASLEMIA 70 TABLET affect the liver?

Yes. DASLEMIA 70 TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.

REFERENCES

1. Laurence Brunton. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies and Cytokines. Goodman and Gillman’s: The Pharmacological Basics of Therapeutics. Twelfth Edition. 2011. Page – 1732-1734.

2. Dilek Keskin, Sevil Sadri, Ahmet Emre Eskazan. Dasatinib for the treatment of chronic myeloid leukemia: patient selection and special considerations. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. October 2016. [Assessed on 10th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066856/

3. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022]. [Accessed on 10th November 2022] https://www.medicines.org.uk/emc/files/pil.10921.pdf

4. Bristol-Myers Squibb Pharma EEIG. Electronic Medicines Compendium (EMC). [Revised in March 2022]. [Accessed on 10th November 2022] https://www.medicines.org.uk/emc/files/pil.3958.pdf

5. Bristol-Myers Squibb Canada. SPRYCEL. [Revised in November 2021] [Assessed on 10th November 2022] https://www.bms.com/assets/bms/ca/documents/productmonograph/SPRYCEL_EN_PM.pdf

AUTHOR DETAILS

Written By Srilekha. R, B.Pharm
Last updated on 12 Nov 2022 | 10:44 AM(IST)