INTRODUCTION

DABLEXA 75MG contain dabigatran etexilate which belongs to a group of medicine called anticoagulants. It is used to prevent the formation of blood clots in the veins after knee or hip replacement surgery. If you have a form of irregular heart rhythm called nonvalvular atrial fibrillation this medicine helps in preventing the formation of blood clots in the brain (stroke) and other blood vessels in the body. It also used to treat blood clots formed in the veins of your legs and lungs and prevent it from reoccurring.

Blood clot is a clump of bloods that has changed from liquid to gel-like or semisolid state. Clotting is a process which prevents the loss of too much bloods in certain instance. By making change in your lifestyle such as not smoking, eating a healthy diet, getting regular exercise, and losing weight can reduce your risk of having a blood clot.

Do not take this medicine if you have severe kidney, liver, heart problems, if you have any bleeding disorders or if you are taking other medicines to reduce blood clotting. Pregnant and breastfeeding women should consult their doctor before taking this medicine. This medicine is strictly not recommended for use in children and adolescents below 18 years old.

USES OF DABLEXA 75MG

• Prevent and treat blood clots

HOW DABLEXA 75MG WORKS

DABLEXA 75MG is a direct thrombin inhibitor which works by reversibly blocking the catalytic site of thrombin and produces a rapid (within 2 hours) anticoagulant action.

DIRECTIONS FOR USE

Always take DABLEXA 75MG exactly as your doctor has told you. This medicine must be taken with or without food. It should be swallowed whole with water. Do not crush or chew the medicine. Your doctor will decide the suitable dose depending on your conditions.

SIDE EFFECTS OF DABLEXA 75MG

HOW TO MANAGE SIDE EFFECTS

Stomach pain:

Keep try to rest and relax. Eat and drink slowly and smaller and frequent meals. Applying a heat pad or covered hot water bottle on your stomach may also help. If still pain persists, speak to your doctor.

Indigestion:

Drink water. Avoid lying down. Take warm bath or use heat bag. Avoid smoking and drinking alcohol. Avoid difficult-to-digest foods.

Nausea:

Keep try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.

Headache:

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor if you are taking,

• warfarin, phenprocoumon, acenocoumarol, heparin, clopidogrel, prasugrel, ticagrelor, rivaroxaban, acetylsalicylic acid (used to reduce blood clot)
• ketoconazole, itraconazole (used to treat fungal infection)
• amiodarone, dronedarone, quinidine, verapamil (used to treat abnormal heart beats)
• tacrolimus, cyclosporine (prevent organ rejection after transplantation)
• glecaprevir and pibrentasvir (used to treats hepatitis C)
• acetylsalicylic acid, ibuprofen, diclofenac (used to treat pain and inflammation)
• St. John’s wort, selective serotonin re-uptake inhibitors or serotonin norepinephrine re-uptake inhibitors (used to treat depression)
• rifampicin or clarithromycin (used to treat infection)
• ritonavir (used to treat HIV infection)
• carbamazepine, phenytoin (used to treat epilepsy)

SYNOPSIS

MORE INFORMATION

Store below 15-30°C and keep out of reach of children.

FAQs ABOUT DABLEXA 75MG

Can DABLEXA 75MG cause hair loss?

This medicine does not usually cause hair loss. Consult your doctor if you face hair loss while taking this medicine.

How does DABLEXA 75MG works?

This medicine is a direct thrombin inhibitor which works by reversibly blocking the catalytic site of thrombin and produces a rapid (within 2 hours) anticoagulant action.

Can I take DABLEXA 75MG during pregnancy?

It is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

REFERENCES

1. KD Tripathi. Drugs Affecting Coagulation, Bleeding and Thrombosis. Essentials of Medical Pharmacology. Seventh Edition,2013. Page-623-624.

2. Weitz JI. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical, 2011. Page-865-866.

3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015.Page-1004-1005.

4. Mandy N Lauw 1 2, John W Eikelboom 1, Michiel Coppens 1 2, Lars Wallentin 3, Salim Yusuf 1, Michael Ezekowitz 4 5, Jonas Oldgren 3, Juliet Nakamya 1, Jia Wang 1, Stuart J Connolly 1; Effects of dabigatran according to age in atrial fibrillation. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. July 2017. [Accessed 28 Oct 2020] https://pubmed.ncbi.nlm.nih.gov/28213368/

5. Boehringer Ingelheim Pharma GmbH & Co. KG, May 2020; Electronic Medicines Compendium (EMC) [Accessed 28 Oct 2020] https://www.medicines.org.uk/emc/files/pil.6229.pdf

6. Boehringer Ingelheim Pharma GmbH & Co. KG, May 2020; Electronic Medicines Compendium (EMC) [Accessed 28 Oct 2020] https://www.medicines.org.uk/emc/files/pil.4703.pdf

7. Boehringer Ingelheim Pharmaceuticals, Inc 2010; U.S. Food & Drug Administration; [Revised on July 2020] [Accessed 28 Oct 2020] https://docs.boehringer-ingelheim.com/Prescribing%20Information/PIs/Pradaxa/Pradaxa.pdf