D Void 0.01% Spray 2.5ml

Diabetes Rx required
OUT OF STOCK

Best Price*  ₹ 830.77
MRP ₹1,038.46
(Inclusive of all taxes) * Mfr: Sun Pharmaceutical Industries Ltd * Country of Origin: India



INTRODUCTION

D VOID contains a medicine called desmopressin which belongs to the group of medicines called synthetic antidiuretic peptide. It is a synthetic analogue called 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. It is used to treat diabetes insipidus, a condition with increased thirst and production of large volumes of dilute urine and primary nocturnal enuresis (bed wetting from age of 5).

Desmopressin works by reducing the amount of water eliminated in the urine by the kidneys. It enhances the reabsorption of water in the kidneys. Avoid drinking large amounts of water or fluid while you are taking this medicine. This could lead to a build-up of water which dilutes the salt in the body and may cause a serious problems or convulsions.

The most common side effects of taking this medicine are headache, stomach pain, swelling of ankles. Do not take this medicine if you have any blood disorders or if you are aged 65 years of age. Consult your doctor before taking. Inform your doctor, before taking this medicine, if you are pregnant or planning a pregnancy, because, blood pressure monitoring is recommended due to the increased risk of pre-eclampsia. D VOID should be used with caution in breastfeeding women. Consult your doctor for advice.

USES OF D VOID

  • Diabetes insipidus (a condition with extreme thirst and continuous production of large volumes of dilute urine)
  • Primary nocturnal enuresis (bed wetting from the age of 5)

HOW D VOID WORKS

Desmopressin mimics the action of endogenous anti-diuretic hormone. After intranasal administration, desmopressin acts as a selective agonist of V2 receptors present in the renal distal tubule and collecting ducts. Binding of desmopressin to V2 receptors, stimulates the production of adenylyl cyclase, which leads to increased reabsorption of water and reduced urine production.

DIRECTIONS FOR USE

Always use this medicine as directed by your physician. It for intranasal use only. Remove the protective cap and prime the spray by pressing several times. Tilt your head backwards and insert the tip of the nozzle into your nostril. Spray into the nostril while breathing in slightly. If required, spray into other nostril in the same way. Wipe your nozzle with a clean tissue and replace the protective cap.

If the spray is not used within 7 days of previous dose, re-prime by pressing the nozzle at least once before using. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF D VOID

SERIOUS

  • confusion
  • convulsion (fits)
  • unexplained weight gain
  • ankle swelling
  • nausea or vomiting
  • signs of allergic reaction (such as itching, skin rashes, swelling of face, lips or throat, difficulty in breathing, chest tightness or coughing)

COMMON

  • headache
  • stomach pain
  • blocked or runny nose, nose bleeds

RARE

  • cerebral edema (water on the brain)

HOW TO MANAGE SIDE EFFECTS

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

Weight gain:

Exercise more regularly. e.g. walking or running. 

Headache:  

Rest and drink plenty of fluids. Do not drink too much alcohol. Ask your doctor to recommend a painkiller.

WARNING & PRECAUTIONS

PREGNANCY

D VOID should be used with caution in pregnant women. Consult your doctor before taking, because blood pressure monitoring is recommended due to the increased risk of pre-eclampsia.

BREASTFEEDING

D VOID should be used with caution in breastfeeding women. Consult your doctor before taking.

DRIVING AND USING MACHINES

Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL

Avoid consumption of alcohol while taking this medicine.

KIDNEY

D VOID should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.

ALLERGY

Do not take this medicine if you are allergic (hypersensitive) to Desmopressin.

HEART DISEASE

D VOID should be taken with caution in patients with heart disease. Consult your doctor for advice.

INTERACTIONS

Talk to your doctor, if you are taking,

  • medicines used for high blood pressure (e.g. captopril, propranolol, enalapril, losartan, valsartan)
  • medicines used to treat depression (e.g. lithium, Amitriptyline, Imipramine, paroxetine, fluoxetine, sertraline)
  • clofibrate (used to treat high cholesterol levels)
  • chlorpromazine (used to treat schizophrenia)
  • carbamazepine (used to treat epilepsy)
  • non-steroidal anti-inflammatory drugs (used to treat pains and inflammatory conditions)
  • glibenclamide (used to treat diabetes)

SYNOPSIS

Drug :   Desmopressin
Pharmacological Category :   Synthetic antidiuretic peptide, Vasopressin Analog
Therapeutic Indication :  

Diabetes insipidus, Primary nocturnal enuresis, Nocturia

Dosage Forms :   Tablet, Nasal spray

MORE INFORMATION

Store at room temperature 15-25°C and keep out of reach of children.

FAQs ABOUT D VOID

Can D VOID cause SIADH?

No. This medicine does not cause syndrome of inappropriate secretion of diuretic hormone.

Can D VOID be used in pregnancy?

Consult your doctor before taking this medicine, if you are pregnant, as blood pressure monitoring is recommended due to the increased risk of pre-eclampsia.

Can we drink alcohol while taking D VOID?

No. Avoid alcohol consumption while taking this medicine. This could lead to serious problems.

REFERENCES

1. Robert F. Reilly and Edwin K. Jackson. Regulation of renal function and vascular volume. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 708-714.

2. Roger K. Long & Hakan Cakmak. Hypothalamic & Pituitary Hormones. Basic and Clinical Pharmacology. 14th Edition. New York McGarw Hill Education 2018.  Page – 681-682.

3. Gerald G. Briggs and Roger K. Freeman. D. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 1085-1086.

4. Ferring Pharmaceuticals. A Study of Minirin Melt in Japanese Patients with Central Diabetes Insipidus (CDI). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on August 2012] [Accessed 26th November 2020] https://clinicaltrials.gov/ct2/show/NCT01280188

5. Fara M. Friedman and Jeffrey P. Weiss. Desmopressin in the treatment of nocturia: clinical evidence and experience. NCBI; PMC US National Library of Medicine, National Institute of Health. December 2013. [Accessed 26th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825109/

6. Labiana Pharmaceuticals S.L.U. Electronic Medicines Compendium (EMC); [Revised on December 2018] [Accessed 26th November 2020] https://www.medicines.org.uk/emc/files/pil.8020.pdf

7. Ferring GmbH. Electronic Medicines Compendium (EMC); [Revised on October 2014] [Accessed 26th November 2020] https://www.medicines.org.uk/emc/files/pil.5449.pdf

8. Ferring Pharmaceuticals Inc. U.S. Food & Drug Administration. [Revised on September 2002] [Accessed 26th November 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/21333slr001_Minirin_lbl.pdf

USEFUL DIAGNOSTIC TESTS

  • Urine analysis
  • Oral glucose tolerance test
  • Kidney function test

Manufacturer/Marketer Details

    Net Qty
    1
    Shelf Life
    NA
    Item Weight
    NA
    No. of Units in a Kit
    NA
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Copyright© 2021 Netmeds Marketplace Ltd.