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INTRODUCTION
CYCLOBID TABLET is a combination of Dicyclomine, and Paracetamol which belongs to the group of medicines called Antispasmodics, Analgesic and Anti-pyretic respectively. It is used for the treatment of stomach cramps, renal and biliary colic, as well as pain from gynaecologic or surgical conditions. It is also used to treat functional bowel disease and irritable bowel syndrome (IBS).
Avoid consuming alcohol while taking CYCLOBID TABLET, as it may increase the side effects. CYCLOBID TABLET is not recommended in patients with an unstable cardiovascular condition with acute haemorrhage, myasthenia gravis, glaucoma, obstructive uropathy, obstructive disease of the gastrointestinal tract, severe ulcerative colitis, or reflux esophagitis.
CYCLOBID TABLET should be used with caution in patients with severe liver and kidney disease, hypertension, coronary heart disease, congestive heart failure, cardiac tachyarrhythmia, psychosis, and delirium (such as elderly patients and/or in patients with mental illness), incomplete intestinal obstruction (the small intestine partially or totally blocked), patients with salmonella dysentery, ulcerative colitis (inflammatory bowel disease), prostatic hypertrophy (prostate gland enlargement), hyperthyroidism, alcoholism, and in patients who take painkillers often for headache, etc.
CYCLOBID TABLET should be used with caution in pregnant women, unless considered necessary. CYCLOBID TABLET is not recommended for use by breastfeeding women. CYCLOBID TABLET is not recommended for use by children under 10 years of age. CYCLOBID TABLET should be used with caution by elderly patients.
The most common side effects of taking CYCLOBID TABLET are hypersensitivity reactions, dry mouth, upset stomach, vomiting, constipation, and gas or bloating. Contact your doctor if any of the symptoms get worse.
USES OF CYCLOBID TABLET
- Treats stomach cramps, renal and biliary colic, as well as pain from gynaecologic or surgical conditions
- Treats functional bowel disease and irritable bowel syndrome (IBS)
HOW CYCLOBID TABLET WORKS
CYCLOBID TABLET is an antispasmodic works by relaxing the muscles in your stomach and gut (intestine). It prevents unexpected muscular contractions (spasms). It also reduces bloating, pain, cramps, and discomfort. Paracetamol is analgesics and antipyretic as well works by inhibiting both COX-1 and COX-2 enzyme and prevents prostaglandin synthesis, thus reliefs pain.
DIRECTIONS FOR USE
Take CYCLOBID TABLET as advised by your physician. With a glass of water, take the tablet. Do not crush or chew the medicine. Depending on your age, body weight, disease condition, your doctor will fix the correct dose and duration for you.
SIDE EFFECTS OF CYCLOBID TABLET
COMMON
- dizziness, drowsiness
- dry mouth
- vision blurred
- nausea
- weakness and nervousness
Stop taking CYCLOBID TABLET and contact your physician immediately if you experience any of the following side effects:
- serious allergic reaction such as rashes, hives, itching, red, swollen, blistered, shortness of breath, wheezing, cough, difficulty breathing, swallowing, or talking, swelling of the face, lips, tongue, or throat, legs and arms
- changes in blood cell types and numbers. If you notice an increase in the number of nosebleeds, or notice that you bruise easily, or get more infections
- fluttering or pounding in your chest, rapid or slow heartbeats
- hallucinations, anxiety, unusual thoughts, or actions
- difficulty with speech or memory
- difficulties in muscle movements or balance
- diarrhoea, severe constipation, or worsening bowel issues
- difficulty swallowing
- where a dicyclomine injection was administered, there is bruising, swelling, or pain
- dizziness, confusion, intense thirst, decreased urine or sweating are all symptoms of dehydration
HOW TO MANAGE SIDE EFFECTS
Constipation
Consume a lot of foods high in fibre, such as grains, fresh fruits, and vegetables. Drink water and exercise regularly. Contact your doctor if constipation persists.
Diarrhea
Drink plenty of water and fruit juice to keep yourself hydrated. Contact your doctor if the diarrhoea did not improve.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operate machinery if you feel drowsiness or dizziness. Avoid alcohol consumption as it aggravates dizziness or drowsiness. Contact your doctor if dizziness or drowsiness worsen.
Nausea And Vomiting
Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. If the nausea does not improve, consult your doctor.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredCYCLOBID TABLET should be used with caution in pregnant women, unless considered necessary. Contact your doctor before taking CYCLOBID TABLET.
BREASTFEEDING
ContraindicatedCYCLOBID TABLET is not recommended in breastfeeding women. Contact your doctor before taking CYCLOBID TABLET.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines, while taking CYCLOBID TABLET, or things that require mental alertness, as it may cause blurred vision or drowsiness.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking CYCLOBID TABLET, as it may increase the side effects.
KIDNEY
Use with CautionCYCLOBID TABLET should be used with caution in patients with severe kidney disease. Contact your doctor before taking CYCLOBID TABLET.
LIVER
Use with CautionCYCLOBID TABLET should be used with caution in patients with severe liver disease. Contact your doctor before taking CYCLOBID TABLET.
ALLERGY
ContraindicatedDo not take CYCLOBID TABLET if you are allergic to dicyclomine, or paracetamol or to other ingredients of this medicine.
HEART DISEASE
Consult your doctorCYCLOBID TABLET is not recommended in patients with unstable cardiovascular condition with acute haemorrhage and should be used with caution in patients with hypertension, coronary heart disease, congestive heart failure, and cardiac tachyarrhythmia. Contact your doctor before taking CYCLOBID TABLET.
USE IN PEDIATRICS
ContraindicatedCYCLOBID TABLET is not recommended for use in children under 10 years of age. Contact your doctor before taking CYCLOBID TABLET.
USE IN GERIATRICS
Use with CautionCYCLOBID TABLET should be used with caution in elderly patients. Contact your doctor before taking CYCLOBID TABLET.
OTHERS
CYCLOBID TABLET is not recommended for use if you have:
- myasthenia gravis
- glaucoma
- obstructive uropathy
- obstructive disease of the gastrointestinal tract
- severe ulcerative colitis
- reflux esophagitis
Before taking CYCLOBID TABLET, inform your doctor if you have:
- heat prostration (such as fever and heat stroke because of decreased sweating)
- psychosis and delirium (such as elderly patients and/or in patients with mental illness)
- incomplete intestinal obstruction (small intestine partially or totally blocked)
- patients with salmonella dysentery
- ulcerative colitis (inflammatory bowel disease)
- prostatic hypertrophy (prostate gland enlargement)
- hyperthyroidism
- suffered from alcoholism
- take painkillers often for headache
INTERACTIONS
A. Drug-Drug interactions:
Tell your doctor if you have recently taken any other medicines, including medicines obtained without a prescription, vitamin supplement or herbal products:
- antiglaucoma agents
- other drugs with anticholinergic activity such as amantadine, antiarrhythmic agents of class I (Ex. quinidine), antihistamines, antipsychotic agents (Ex. phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (Ex. meperidine), nitrates and nitrites, tricyclic antidepressants, sympathomimetic drugs, and other medications with anticholinergic effects
- digoxin (medicine used for heart failure)
- warfarin (prevents blood clot)
- metoclopramide or domperidone (medicine used to prevent nausea and vomiting)
- cholestyramine (medicine used to treat high cholesterol levels)
- imatinib (medicine used to treat leukaemia and some stomach tumours)
Overdosage:
If you or anyone else accidentally take too much of CYCLOBID TABLET, consult your doctor immediately or visit the nearby hospital. Signs and symptoms of overdose may include headache, nausea, vomiting, blurred vision, dilated pupils, hot, dry skin, dizziness, dryness of the mouth, difficulty in swallowing, CNS stimulation including convulsion, loss of appetite, stomach pain and liver damage.
SYNOPSIS
| Drug | : | Dicyclomine, Paracetamol |
| Pharmacological Category | : | Antispasmodics, Analgesic and Antipyretics |
| Therapeutic Indication | : | Relief pain & and irritable bowel syndrome (IBS) |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep CYCLOBID TABLET out of reach of children
- Store CYCLOBID TABLET below 25°C
FAQs ABOUT CYCLOBID TABLET
Q: What is CYCLOBID TABLET used for?
A: CYCLOBID TABLET is used for the treatment of stomach cramps, renal and biliary colic, as well as pain from gynecologic or surgical conditions. It is also used to treat functional bowel disease and irritable bowel syndrome (IBS). Consult your doctor before taking CYCLOBID TABLET.
Q: What are the side effects of taking CYCLOBID TABLET?
A: The most common side effects of taking CYCLOBID TABLET are hypersensitivity reactions, dry mouth, upset stomach, vomiting, constipation, and gas or bloating. Contact your doctor if any of the symptoms get worse.
Q: Is CYCLOBID TABLET safe during pregnancy?
A: CYCLOBID TABLET should be used with caution in pregnant women, unless considered necessary. Contact your doctor before taking CYCLOBID TABLET.
Q: Is CYCLOBID TABLET safe during breast-feeding?
A: CYCLOBID TABLET is not recommended for breastfeeding women. Contact your doctor before taking CYCLOBID TABLET.
Q: Can we use CYCLOBID TABLET in children?
A: CYCLOBID TABLET is not recommended for use by children under 10 years of age. Contact your doctor before taking CYCLOBID TABLET.
Q: How does CYCLOBID TABLET work?
A: CYCLOBID TABLET is an antispasmodic that works by relaxing the muscles in your stomach and gut (intestine). It prevents unexpected muscular contractions (spasms). It also reduces bloating, pain, cramps, and discomfort. Paracetamol is an analgesic and an antipyretic as well. It works by inhibiting both COX-1 and COX-2 enzymes and preventing prostaglandin synthesis, thus relieving pain.
Q: Is CYCLOBID TABLET good for stomach pain?
A: CYCLOBID TABLET relieves stomach and intestinal cramps, muscle spasms, abdominal pain, constipation, and other GI discomforts by relaxing the muscles and preventing normal gut movements.
Q: Is CYCLOBID TABLET used for periods?
A: CYCLOBID TABLET helps to relieve the symptoms of menstrual (period-related) pain and cramping.
REFERENCES
1. KD Tripathi. Anticholinergic Drugs and Drugs Acting on Autonomic Ganglia. Essentials of medical pharmacology. Seventh edition. 2013. Page – 117.
2. KD. Tripathi. Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 206.
3. Niranjan Mayadeo. Role of camylofin and its combinations in obstetrics and gynaecological practice: a review of Indian evidence. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. January 2019. https://www.ijrcog.org/index.php/ijrcog/article/view/6014/4142
4. Shah DA, Rana JP, Chhalotiya UK, Baldania SL, Bhatt KK. Development and validation of a liquid chromatographic method for estimation of dicyclomine hydrochloride, mefenamic Acid and paracetamol in tablets. Indian Journal of Pharmaceutical Sciences. Nov-Dec 2014. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293684/
5. Bethesda (MD). Dicyclomine. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 07 September 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Dicyclomine
6. Axcan Pharma US, Inc. U.S. Food & Drug Administration. [Revised in July 2021] [Accessed on 12 September 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/007409s041lbl.pdf
7. Accord. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 12th September 2022] https://www.medicines.org.uk/emc/files/pil.5916.pdf
8. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in February 2021] [Accessed on 12th September 2022] https://www.medicines.org.uk/emc/files/pil.5164.pdf
9. Balkanpharma – Dupnitsa AD. Electronic Medicines Compendium (EMC). [Revised in June 2019] [Accessed on 12th September 2022] https://www.hpra.ie/img/uploaded/swedocuments/2b04cfdb-8571-4543-a4c9-b1380e0a92c3.pdf
10. Hikma Pharmaceuticals USA Inc. Dicyclomine hydrochloride. [Revised in May 31, 2018] [Accessed on 12th September 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5a553bda-1e3d-4b80-913f-73dd54655033
11. Life Line Home Care Services, Inc. Dicyclomine hydrochloride. [Revised in February 2012] [Accessed on 12th September 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e576f409-d319-4878-9863-25988be7fde1##
12. Leeford Healthcare Ltd. Dicyclomine, Paracetamol. [Accessed on 12 September 2022] https://www.leeford.in/product/1015/leemol-dc-tablet
13. Dicyclomine. Drugs.com. [Accessed on 12 September 2022] https://www.drugs.com/mtm/dicyclomine.html
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