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INTRODUCTION
CUREJOINT AC TABLET is a combination of Aceclofenac and Diacerein which belongs to the group of medicines called Non-steroidal Anti-inflammatory drugs (NSAIDs) and Anthraquinones respectively. It is used to relieve pain also reduces swelling and redness in adult patients suffering from osteoarthritis of hip and knee joints.
Osteoarthritis can be defined as a degenerative joint disorder which is categorized by swelling, stiffness and painful joints. CUREJOINT AC TABLET is not recommended for use in patients having severe liver, kidney and heart disease.
CUREJOINT AC TABLET is not recommended for use in pregnant women and breast-feeding mothers unless clearly advised by your doctor. You are advised to inform your doctor if you have any problems becoming pregnant, as this medicine may make it more difficult to become pregnant.
CUREJOINT AC TABLET is not recommended for use in children and adolescents aged under 18 years. Also, it is not recommended for use in elderly patients aged above 65 years.
Avoid alcohol consumption while taking this medicine as it may increase your risk of liver damage. The most common side effects of CUREJOINT AC TABLET are dizziness, nausea, diarrhea and flatulence. Consult your doctor if any of the side effects worsen.
USES OF CUREJOINT AC TABLET
- Relieves pain, reduce redness and swelling in adults suffering from osteoarthritis (arthritis of joints)
HOW CUREJOINT AC TABLET WORKS
CUREJOINT AC TABLET is used to reduce pain and swelling, where aceclofenac acts as an anti-inflammatory agent and painkiller thus blocks the production of inflammatory mediators called prostaglandins in the body which are responsible for causing pain and swelling at the site of injury. As a result, it reduces the joint pain and swelling. Diacerein works by blocking the actions of a protein called interleukin-1β and cytokines which are involved in inflammation and degeneration of tissues thus relieves inflammation and damage of tissues.
DIRECTIONS FOR USE
Take CUREJOINT AC TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF CUREJOINT AC TABLET
COMMON
- dizziness
- nausea
- diarrhea, flatulence
- frequent bowel movements
- rash, itching
- eczema (red and itchy rash)
UNCOMMON
- swelling or irritation of the lining of stomach
- constipation
- vomiting
- ulcerations in the mouth
- raised circular itchy red, stinging and burning patches on the skin (hives)
RARE
- allergic reactions (such as itching, redness or skin rashes)
- vision problems
- heart failure
- high blood pressure
- breathing difficulties
- bleeding and ulcerations in the stomach or intestine
Stop taking CUREJOINT AC TABLET and contact your doctor immediately if you experience any of the following side effects:
- unusual frequent liquid or watery stools
- signs of serious liver disease (such as yellow discoloration of eyes and skin (jaundice), impaired consciousness and itchy skin)
- severe allergic reactions (such as fever, breathing difficulties, wheezing, abdominal pain, vomiting, swelling of the face and throat which could be life threatening if not treated immediately)
- serious skin reactions (such as stevens-johnson syndrome or toxic epidermal necrolysis) accompanied by skin rash with widespread blistering and peeling of the skin. The rash can also occur in the mouth, throat or eyes which is associated with fever, headache and aching of the joints
- signs of meningitis (such as high fever, headache, vomiting, blotchy red rashes, neck stiffness, sensitivity and intolerance to light)
- blood in faeces causing black tarry stools
- vomiting blood or dark particles similar to coffee grounds
- signs of kidney failure (such as confusion, tiredness, nausea, low urine output and fluid retention)
- severe indigestion or heartburn
- abdominal pain or any other abnormal abdominal symptoms
- high potassium levels in the blood causing irritation in the blood vessels leading to inflammatory condition such as vasculitis and can cause symptoms such as severe tiredness, breathlessness, joint pain and frequent infections along with bruising
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Take CUREJOINT AC TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if the symptom does not improve.
Flatulence:
Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. If the symptom does not improve, contact your doctor.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals and drink plenty of water. Exercise more regularly. If the symptom does not improve, contact your doctor.
Diarrhoea:
Drink lot of fluids such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
WARNING & PRECAUTIONS
PREGNANCY
CUREJOINT AC TABLET is not recommended for use in pregnant women unless considered clearly necessary. It should not be used particularly during last three months of pregnancy. Consult your doctor before taking CUREJOINT AC TABLET.
BREASTFEEDING
CUREJOINT AC TABLET is not recommended for breast feeding mothers unless considered clearly necessary as it is unknown whether this medicine passes through breast milk. Consult your doctor before taking CUREJOINT AC TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizziness, drowsiness, vertigo, tiredness or any difficulties in eyesight after taking CUREJOINT AC TABLET.
ALCOHOL
Avoid consumption of alcohol while taking CUREJOINT AC TABLET because it might make you dizzier and increase your risk of liver damage.
KIDNEY
CUREJOINT AC TABLET is not recommended for use in patients having severe kidney disease and should be used with caution in patients with kidney disease. Consult your doctor before taking CUREJOINT AC TABLET.
LIVER
CUREJOINT AC TABLET is not recommended for use in patients having severe liver failure and should be used with caution in patients with liver disease. Consult your doctor before taking CUREJOINT AC TABLET.
ALLERGY
Do not take CUREJOINT AC TABLET if you are allergic to diacerein, acelofenac, aspirin or any other NSAIDs (such as ibuprofen, naproxen or diclofenac).
LUNGS
CUREJOINT AC TABLET should be used with caution in patients having asthma or any other breathing difficulties. Consult your doctor before taking CUREJOINT AC TABLET.
HEART DISEASE
CUREJOINT AC TABLET is not recommended for use in patients having any heart diseases such as heart attack, stroke, mini-stroke, blockages to blood vessels to the heart or undergone any heart surgeries to remove heart blocks. [GBNKEYWORD should be used with caution among patients having high blood pressure, blood clots, angina (chest pain) and elevated cholesterol or fats. Consult your doctor before taking CUREJOINT AC TABLET.
OTHERS
CUREJOINT AC TABLET is not recommended for use if you:
- have a history of or you are suffering or suspecting stomach ulcer, blood in vomit or faeces (black tarry stools)
- you have or have had problems with your blood circulation (peripheral arterial disease)
- have suffering from bleeding or any type of blood clotting disorders
Before taking CUREJOINT AC TABLET, inform your doctor if you:
- have any inflammatory bowel diseases such as ulcerative colitis or crohn’s disease, including ulceration, perforation or bleeding in the stomach or bowel
- have any rare inherited blood disorder such as porphyria
- have or ever had problems with the circulation of the blood to your brain
- have smoking habit
- have diabetes
- have any autoimmune condition called systemic lupus erythematosus or any connective tissue disorders
- are suffering from chicken pox
- are recovering from any major surgeries
Use in pediatrics:
CUREJOINT AC TABLET is not recommended for use in children and adolescents (aged under 18 years). Consult your child’s doctor for advice.
Use in geriatrics:
CUREJOINT AC TABLET is not recommended for use in elderly patients (aged 65 years and above). Consult your doctor before taking CUREJOINT AC TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking CUREJOINT AC TABLET inform to your doctor, if you are taking any of these medicines:
- selective serotonin-reuptake inhibitors (medicines used to treat mental health problems such as depression and mania) Ex. citalopram, escitalopram, fluvoxamine, fluoxetine, paroxetine, sertraline, lithium
- cardiac glycosides (medicines used to treat heart failure and irregular heart rhythm) Ex.digoxin, digitoxin
- angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists (medicines used to treat high blood pressure) Ex. enalapril, lisinopril, losartan, candesartan, hydralazine, methyldopa, clonidine, moxonidine, propranolol
- medicines used to treat bacterial infections (Ex. ciprofloxacin, oflaxacin, levofloxacin, moxifloxacin)
- diuretics (medicines used to increase the urine excretion) Ex. furosemide, amiloride and thiazides such as chlorthalidone, hydrochlorothiazide
- anticoagulants (medicines used to treat blood clotting) Ex. warfarin, heparin
- methotrexate (medicine used to treat cancer and autoimmune disorders such as arthritis and skin diseases)
- mifepristone (medicine used to promote abortion during early pregnancy)
- corticosteroids (medicines used to treat swelling and inflammation) Ex. hydrocortisone, prednisolone
- medicine used to suppress immune system after organ transplant (Ex. ciclosporin, tacrolimus
- zidovudine (medicine used to treat HIV)
- anti-diabetics (medicines used to lower blood sugar levels) Ex. glibenclamide, glicazide, tolbutamide)
- non-steroidal anti-Inflammatory drugs (NSAIDs) (medicines used to relieve pain and inflammation) Ex. aspirin, ibuprofen, naproxen, celecoxib and etoricoxib
- anti-platelet drugs (medicines used to prevent blood clots) Ex. clopidogrel
Overdosage:
If you or anyone else accidentally take too much of CUREJOINT AC TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of CUREJOINT AC TABLET includes headache, nausea, vomiting, epigastric pain, gastrointestinal irritation or bleeding, rarely diarrhea, disorientation, excitation, coma, drowsiness, dizziness, ringing sensation in ears, low blood pressure, respiratory depression, fainting, occasionally convulsions, acute kidney failure and liver damage.
SYNOPSIS
| Drug | : | Aceclofenac, Diacerein |
| Pharmacological Category | : | Non-steroidal Anti-inflammatory drugs, Anthraquinones |
| Therapeutic Indication | : | Osteoarthritis |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep CUREJOINT AC TABLET out of reach of children
- Store CUREJOINT AC TABLET at room temperature
FAQs ABOUT CUREJOINT AC TABLET
How does CUREJOINT AC TABLET work?
Aceclofenac works by inhibiting the production of inflammatory mediators called prostaglandins in the body which are responsible for causing pain and swelling at the site of injury. As a result, it reduces the joint pain and swelling. Diacerein works by blocking the actions of a protein called interleukin-1β and cytokines which are involved in inflammation and degeneration of tissues thus relieves inflammation and damage of tissues.
Is CUREJOINT AC TABLET safe to use in children?
CUREJOINT AC TABLET is not recommended for use in children and adolescents (below 18 years of age). Consult your child’s doctor for advice, your child’s doctor may prescribe safer alternative medicine for your child to treat the pain.
Is CUREJOINT AC TABLET safe to use in patients with liver problems?
CUREJOINT AC TABLET is not recommended for use in patients having severe liver failure and should be used with caution in patients with liver disease. Your doctor may monitor your liver function test before and during treatment with this medicine to prevent the risk of any unusual effects. Consult your doctor before taking CUREJOINT AC TABLET.
What are the common side-effects of CUREJOINT AC TABLET?
The most common side-effects of CUREJOINT AC TABLET are watery stools, dizziness, nausea, abdominal pain, rash and itching. Consult your doctor immediately if any of the side effects bothers you.
Can CUREJOINT AC TABLET taken along with alcohol?
No, CUREJOINT AC TABLET is not advised to be taken along with alcohol, as it may make you feel dizzier and aggravate your liver symptoms. Consult your doctor for advice before taking the medicine.
Can I take a higher dose of CUREJOINT AC TABLET to improve my pain-relieving effects?
No, do not take a higher dose of CUREJOINT AC TABLET than recommended by your doctor. Taking a higher dose of CUREJOINT AC TABLET without consulting a doctor can increase the risk of side effects such as prolonged diarrhea causing dehydration and decreased potassium level in the blood. If the prescribed dose is not effective for you, consult your doctor for a suitable higher dose. Never consume a higher dose of CUREJOINT AC TABLET without proper medical advice.
REFERENCES
1. KD Tripathi. NSAIDs and Antipyretic analgesics. Essentials of Medical Pharmacology. Eighth Edition, 2019. Page – 221.
2. T S A Fidelix, B G D O Soares, V F M Trevisani. Diacerein for osteoarthritis. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. January 2006. [Accessed 25th May 2022] https://pubmed.ncbi.nlm.nih.gov/16437519/
3. European medicine agency. Diacerein. [ Accessed on 25th May 2022] https://ec.europa.eu/health/documents/community-register/2014/20140904128570/anx_128570_en.pdf
4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in January 2021]. [Accessed on 25th May 2022] https://www.medicines.org.uk/emc/product/4240/pil
5. Aceclofenac + Diacerein Tablet. Central Drugs Standard Control Organization. April 2008. [Accessed on 25th May 2022] https://cdscoonline.gov.in/CDSCO/Drugs
USEFUL DIAGNOSTIC TESTS
- Liver function test
PRODUCT DETAILS
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