INTRODUCTION

CRIXAN 125MG/5ML SUSPENSION contains Clarithromycin which belongs to the group of medicines called Macrolide Antibiotics. It is used to treat bacterial infections in the chest, throat and sinuses in children above 6 months to 12 years of age. It is also used to treat inflammation of the middle ear (otitis media) and infections of the skin and the layers of flesh just under the skin.

Before prescribing this medicine, your doctor may want your child to undergo few diagnostic tests to determine the exact cause of your infection before starting with the medication.

Before giving CRIXAN 125MG/5ML SUSPENSION to your child, inform your doctor if the child has been diagnosed with coronary artery disease, severe heart failure or slowed heart rate.

CRIXAN 125MG/5ML SUSPENSION is not recommended in children with a history of heart rhythm disorders (such as ventricular cardiac arrhythmia, and fast heart rhythm), in ‘long QT syndrome’ (abnormality in electrocardiogram) and in children with severe liver or kidney disorders or those prone to fungal infections.

The most common side effect of taking this medicine is stomach pain, headache, diarrhoea, and insomnia. Consult a doctor immediately if any of the above symptoms worsen.

USES OF CRIXAN 125MG/5ML SUSPENSION

• Used to treat ear nose and throat infections, respiratory tract infections, skin and soft tissue infections in children

HOW CRIXAN 125MG/5ML SUSPENSION WORKS

CRIXAN 125MG/5ML SUSPENSION prevents the growth of bacteria by interfering with its protein synthesis and binds specific proteins present in the bacterial ribosomes, thus stopping the growth of the bacteria inside the body, which helps to reduce the infection and its symptoms.

DIRECTIONS FOR USE

Give CRIXAN 125MG/5ML SUSPENSION to your child as advised by your physician. It is for pediatric use.

Shake the bottle well to loosen the dry powder. Add the sterile water provided with this pack up to the ring mark present on the bottle surface. Add extra water if required to adjust the volume up to the ring mark. Close the bottle tightly and shake the mixture well.

Your doctor will decide the correct dose and duration for your child depending on the age, body weight and disease condition. It is important to consume CRIXAN 125MG/5ML SUSPENSION for the stipulated duration recommended by your doctor to achieve control over the infection.

SIDE EFFECTS OF CRIXAN 125MG/5ML SUSPENSION

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Give lots of fluids, such as water or fruit juices to keep your child hydrated. Avoid taking any medicine on your own for treating diarrhoea. Consult your doctor if the symptom did not improve.

Headache: 

Give plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Consult your doctor if the symptom did not improve.

Nausea or Vomiting:

Give this medicine with, or just after meals. Stick to simple meals. Avoid giving oil-rich or spicy foods.

Stomach pain:

Give smaller and frequent meals and keep a heating pad on the stomach. If the symptom does not improve, contact your doctor.

WARNING & PRECAUTIONS

DRIVING AND USING MACHINES

Do not allow your child drive or play outdoors, as CRIXAN 125MG/5ML SUSPENSION may cause dizziness or blurry vision. Consult your doctor before giving CRIXAN 125MG/5ML SUSPENSION.

KIDNEY

CRIXAN 125MG/5ML SUSPENSION is not recommended in children with a severe kidney disorder. Consult your doctor before giving CRIXAN 125MG/5ML SUSPENSION to your child.

LIVER

CRIXAN 125MG/5ML SUSPENSION is not recommended in children with severe liver disorder. Consult your doctor before giving CRIXAN 125MG/5ML SUSPENSION to your child.

ALLERGY

Do not give CRIXAN 125MG/5ML SUSPENSION if the child is allergic (hypersensitive) to Clarithromycin and other macrolide antibiotics (such as azithromycin and erythromycin) or any other constituents of this medicine.

LUNGS

CRIXAN 125MG/5ML SUSPENSION should be used with caution in children with pneumonia. Consult the doctor before giving CRIXAN 125MG/5ML SUSPENSION.

HEART DISEASE

CRIXAN 125MG/5ML SUSPENSION is not recommended for children with a family history of heart rhythm disorders known as ventricular cardiac arrhythmia, including the type of ventricular tachycardia (torsades de pointes) and if you have long QT syndrome (showing abnormality in electrocardiogram). CRIXAN 125MG/5ML SUSPENSION should be taken with caution in children diagnosed with coronary artery disease, severe heart failure or slowed heart rate. Consult a doctor before giving this medicine to your child.

INTERACTIONS

A. Drug-Drug interactions:

Before giving CRIXAN 125MG/5ML SUSPENSION to your child, inform your doctor if your child is taking any of the following medicine:

• astemizole or terfenadine (medicine to treat hay fever and allergy)
• cisapride (medicine to treat stomach disorder)
• pimozide (medicine to treat mental disorder)
• ticagrelor, ranolazine (medicine to treat heart and circulatory disease)
• colchicine (medicine to treat gout)
• quinidine or disopyramide (medicine to treat heartbeat disorders)
• theophylline (medicine to treat asthma)
• rifampicin, rifabutin or rifapentine, azithromycin, erythromycin, lincomycin, clindamycin (medicine to treat certain bacterial infections)
• fluconazole, itraconazole (medicine to treat fungal infections)
• medicines used to treat epilepsy
• vinblastine (medicine to treat cancer)

Overdosage:

If your child or anyone else accidentally took too much of this medicine, consult your doctor immediately.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Store at room temperature

FAQs ABOUT CRIXAN 125MG/5ML SUSPENSION

What is CRIXAN 125MG/5ML SUSPENSION used for?

CRIXAN 125MG/5ML SUSPENSION is used to treat bacterial infections in the chest, throat and sinuses in children above 6 months to 12 years of age. It is also used to treat inflammation of the middle ear (otitis media) and infections of the skin and the layers of flesh just under the skin.

If my child starts feeling well, can I skip giving the dose of CRIXAN 125MG/5ML SUSPENSION?

No. You should complete giving the full course of CRIXAN 125MG/5ML SUSPENSION as prescribed by your doctor. It is important that CRIXAN 125MG/5ML SUSPENSION be taken at the right dose and for the right duration given otherwise, the symptoms can prevail and sometimes worsen.

Will giving CRIXAN 125MG/5ML SUSPENSION to the child more than the given dose provide a faster cure?

No, self-medication will always harm and result in an adverse reaction. Upon giving CRIXAN 125MG/5ML SUSPENSION to your child CRIXAN 125MG/5ML SUSPENSION more than the given dose, the child may suffer from serious vomiting and stomach pain, in such cases consult a doctor immediately and take them to the nearby hospital.

Who cannot take CRIXAN 125MG/5ML SUSPENSION?

CRIXAN 125MG/5ML SUSPENSION is not suitable for people who have an allergic reaction to macrolide antibiotics, if the child have fast, pounding or irregular heartbeat or having abnormally low levels of potassium or magnesium in your blood. Consult a doctor before giving CRIXAN 125MG/5ML SUSPENSION to your child.

Can CRIXAN 125MG/5ML SUSPENSION cause diarrhoea?

Yes, CRIXAN 125MG/5ML SUSPENSION may cause serious diarrhoea during or after antibiotic use. Usually, discontinuation of medicine can subside diarrhoea. However, if diarrhoea persists or if there is blood in the stool then immediately consult a doctor.

Can CRIXAN 125MG/5ML SUSPENSION be given safely to children?

Your doctor will give the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before giving CRIXAN 125MG/5ML SUSPENSION to your child.

REFERENCES

1. KD Tripathi. Clarithromycin. Essentials of Medical Pharmacology. Seventh Edition,2013. Page – 803.

2. Gutierrez-Castrellon, Pedro, José Luis Mayorga-Buitron, Vanessa Bosch-Canto, Guillermo Solomon-Santibanez, and Agustin de Colsa-Ranero. Efficacy and safety of clarithromycin in pediatric patients with upper respiratory infections: a systematic review with meta-analysis. Revista de Investigación Clínica. 2012. [Accessed on 10th June 2022] https://web.archive.org/web/20200210135107id_/https://pdfs.semanticscholar.org/5a8c/2d0f8d189068a8a1a6d5682a5b77952ec0dd.pdf

3. Sun Pharmaceutical Industries Europe B.V. Electronic Medicine Compendium (emc). [Revised in March 2022] [Accessed on 10th June 2022] https://www.medicines.org.uk/emc/files/pil.4360.pdf

4. Sun Pharmaceutical Industries Europe B.V. Electronic Medicine Compendium (emc). [Revised in February 2022] [Accessed on 10th June 2022] https://www.medicines.org.uk/emc/files/pil.12806.pdf

5. Abbott Laboratories. [Accessed on 10th June 2022]. U.S. Food & Drug Administration. [Revised in 2012] [Accessed 10th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050662s044s050,50698s026s030,050775s015s019lbl.pdf

6. Getz Pharma. Pvt. Limited. [Revised in August 2009] [Accessed on 10th June 2022] https://getzpharma.com/wp-content/uploads/2021/08/Claritek-Insert.pdf

USEFUL DIAGNOSTIC TESTS

• Complete Blood Count
• Peripheral Smear Examination
• Blood Culture Tests

AUTHOR DETAILS

Written By Dr. Janet.C, Pharm.D
Last updated on 12 Oct 2022 | 07:37 PM(IST)