Crinone 8% Gel 1'S

Hormonal Therapy Rx required
NOT AVAILABLE

Best Price*  ₹ 159.72
MRP ₹199.65
(Inclusive of all taxes) Get the best price on this product on orders above Rs. 500 * Mfr: Merck Ltd * Country of Origin: NA



INTRODUCTION

CRINONE 8% contains Progesterone which belongs to the group of medicines called progestins. It is used for the treatment of infertility in females due to a deficiency of female sex hormone called progesterone during the menstrual cycle. During the luteal phase of menstrual cycle, the hormone progesterone produced may be either insufficient or absent to maintain the lining of uterus and support early pregnancy. CRINONE 8% provides progesterone and supports your new pregnancy by maintaining the lining of the uterus.

CRINONE 8% is for intra-vaginal use only. Once the gel is inserted into your vagina, progesterone would be slowly released into the bloodstream throughout the day. It can stay in the vagina for several days. During this time, a beige-brownish clumpy or cloudy white discharge can be seen. This discharge can cause pain, swelling or irritation in your vagina, but it is nothing to worry about.

The most common side effects of using this medicine are headache, tiredness, stomach pain or tender breasts. Contact your doctor if these symptom bothers you. Before using this medicine, inform your doctor if you have or ever had unexplained vaginal bleeding or previous miscarriage. Your doctor will suggest you a suitable alternative therapy. Consult your doctor before using this medicine if you are pregnant, because CRINONE 8% is generally not used during pregnancy. However, if this medicine helps you to get pregnant, you may be asked to continue using it further, to support your new pregnancy.

USES OF CRINONE 8%

  • Treats infertility in females due to a deficiency of progesterone

HOW CRINONE 8% WORKS

Progesterone binds to and activates the progesterone receptor (PR) present in the stromal cells during the secretory phase of menstrual cycle and during pregnancy. It helps to establish and maintain pregnancy by maintaining the lining of uterus and by supporting the development of embryo during early pregnancy.

DIRECTIONS FOR USE

Apply this medicine as directed by your physician. It is for intra-vaginal use only. Use the pre-filled applicator, supplied in the pack to apply the medicine. Hold the applicator by the thick end and face the thin end down to the ground. Shake the applicator down to move all the gel inside to the thin end.

Remove the cap from thin end of the applicator. Lie down with your knees bent. Carefully insert the applicator into your vagina and press the air tank, to deliver the gel into your vagina. Discard the applicator after use. Continue to use this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF CRINONE 8%

SERIOUS

  • allergic skin reactions

COMMON

  • headache
  • feeling tired
  • stomach or gut cramps
  • breast tenderness

HOW TO MANAGE SIDE EFFECTS

Stomach cramps:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

Headache:  

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

WARNING & PRECAUTIONS

PREGNANCY

CRINONE 8% is generally not recommended for use during pregnancy. However, if this medicine helps you to get pregnant, you may be asked to continue using it further, to support your new pregnancy.

BREASTFEEDING

CRINONE 8% should be used with caution if you are breastfeeding women. Consult your doctor before taking this medicine.

DRIVING AND USING MACHINES

Do not drive or operate any machines, because this medicine may make you feel dizzy.

ALCOHOL

Avoid consumption of alcohol while taking this medicine, because it can increase the risk of side effects.

KIDNEY

CRINONE 8% should be used with caution in patients with kidney disease. Consult your doctor for advice.

LIVER

CRINONE 8% should be used with caution in patients with liver disease. Consult your doctor for advice.

ALLERGY

Do not take this medicine if you are allergic to progesterone.

LUNGS

CRINONE 8% should be used with caution in patients with asthma or other respiratory disorders. Consult your doctor for advice.

HEART DISEASE

CRINONE 8% should be used with caution in patients with heart problems. Consult your doctor for advice.

OTHERS

Do not use this medicine, if you:

  • have an unexplained vaginal bleeding, porphyria (an inherited blood disorder), cancer or at risk of cancer in breasts or genital organs
  • had previous abortion and in patients who ever had a blood clot due to thrombophlebitis (swollen veins), thromboembolic disorder (a blocked blood vessel) or a stroke

INTERACTIONS

Tell your doctor about all the medicines you use, including non-prescription and prescription medicines and herbal supplements.

SYNOPSIS

Drug :   Progesterone
Pharmacological Category :   Progestins
Therapeutic Indication :   Infertility in females
Dosage Forms :   Tablet, Capsule, Gel, Ointment, Injection, Pessary, Spray

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT CRINONE 8%

Can CRINONE 8% delay your periods?

Yes. Due to its tendency to sustain pregnancy by maintaining the uterine lining, this medicine may cause a delay in the onset of periods in non-pregnant women.

Can CRINONE 8% cause yeast infection?

Currently, there are not enough evidence about this medicine on the incidence of yeast infection. However, presence of this medicine can cause irritation, pain or swelling in vagina which is nothing to worry out. If you experience any unusual symptoms after using this medicine, contact your doctor.

Can CRINONE 8% cause bleeding?

No. This medicine does not cause any unnecessary vaginal bleeding. However, it should be taken with caution in people who have unexplained vaginal bleeding.

REFERENCES

1. KD. Tripathi. Hormones and related drugs: Estrogens, Progestins and Contraceptives. Essentials of medical pharmacology. Seventh edition. 2013. Page – 316-319.

2. Ellis R. Levin and Stephen R. Hammes. Estrogens and Progestins. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1180-1184.

3. Brigham and Women's Hospital. Comparison of Crinone 8% Intravaginal Gel or Intramuscular Progesterone Supplementation for In Vitro Fertilization (IVF) and Embryo Transfer (ET) Cycles in Women Under Age 40 Years Old. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on September 2011] [Accessed 7th November 2020] https://clinicaltrials.gov/ct2/show/NCT00656201

4. Merck KGaA. Phase 3 Trial to Evaluate the Efficacy and Safety of COL-1620 Vaginal Progesterone Gel. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on December 2015] [Accessed 7th November 2020] https://clinicaltrials.gov/ct2/show/NCT01863680

5. Shoji Kokeguchi, Naoki Hayashi, Daniela Rogoff,  Shin Shimizu  and Osamu Ishihara. Phase III trial of 8% vaginal progesterone gel for luteal phase support in Japanese women undergoing in vitro fertilization and fresh embryo transfer cycles. NIH US National Library of Medicine, National Institute of Health. [Revised on January 2017] [Accessed 7th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715867/

6. Central Pharma (Contract Packaging) Ltd. Electronic Medicines Compendium (EMC). [Revised on August 2019] [Accessed 7th November 2020] https://www.medicines.org.uk/emc/files/pil.1283.pdf

7. Central Pharma (Contract Packaging) Ltd. Health Products Regulatory Authority (HPRA). [Revised on January 2016] [Accessed 7th November 2020] https://www.hpra.ie/img/uploaded/swedocuments/235-1-PIL-CRINONE%208_%20W-W%20PROGESTERONE%20VAGINAL%20GEL%20(15)%20(CZECH)%20(MAR%2015)-2171633-05012016143145-635876011067688750.pdf

USEFUL DIAGNOSTIC TESTS

  • Anti-Mullerian Hormone
  • Glycosylated Hemoglobin
  • Testosterone Total
  • Thyroid Stimulating Hormone

Manufacturer DETAILS

    Max Discount
    20 %
    Country Of Origin
    NA
ALTERNATE SALTS
Emprogest 8% Gel 1.125gm
Prescription Hormonal Therapy Rx required
Rs.199.25
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Copyright© 2021 Netmeds Marketplace Ltd.