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INTRODUCTION
COVERSYL 8MG contains Perindopril which belongs to the group of medicines called Angiotensin Converting Enzyme Inhibitors. It is used to treat hypertension in adults. Hypertension is a condition in which the force of the blood against blood vessel walls is too high. Symptoms of hypertension includes early morning headaches, irregular heartbeat, vision changes, feeling overtiredness, vomiting, confusion, anxiety, and chest pain. It is also used to treat heart failure (a condition where the pumping of heart is inadequate to meet body’s need which is characterized by shortness of breath, fatigue, fast heartbeat). It also reduces the risk of cardiac events such as heart attack in patients with stable coronary artery disease (a condition where the blood supply to the heart is reduced or blocked resulting in pain or discomfort in chest, arms or shoulders; weakness, light-headedness and feeling sick), in patients who have the history of heart attack and/or an operation to improve blood supply to heart.
Perindopril works by inhibiting the activity of an enzyme called angiotensin converting enzyme (an enzyme which is responsible for causing constriction of blood vessels), resulting in easy flow of blood around the body. Your doctor may check your kidney function, blood pressure, and the amount of electrolytes (Ex. potassium) in your body prior to the treatment or at regular intervals along with the treatment.
COVERSYL 8MG is not recommended for use in patients having kidney artery stenosis. COVERSYL 8MG should be used in caution with patient having aortic stenosis, hypertrophic cardiomyopathy, diabetes, liver, and kidney problems or under dialysis. If you are pregnant or breast-feeding, consult your doctor for advice before taking this medicine. COVERSYL 8MG is not recommended for use in children and adolescents up to the age of 18 years. The most common side effects of taking COVERSYL 8MG are low blood pressure, headache, dizziness, muscle cramps, shortness of breath, cough and headache. Consult your doctor if the symptoms worsen.
USES OF COVERSYL 8MG
- To treat hypertension (high blood pressure)
- To treat heart failure (a condition where the pumping of heart is inadequate to meet body’s need)
- To reduce the risk of heart attack in patients with stable coronary artery disease (a condition where the blood supply to the heart is reduced or blocked) and in patients who have the history of heart attack and/or in surgeries to improve blood supply to the heart
HOW COVERSYL 8MG WORKS
COVERSYL 8MG works by inhibiting the activity of an enzyme called angiotensin converting enzyme (an enzyme which is responsible for causing constriction of blood vessels), resulting in easy flow of blood around the body.
DIRECTIONS FOR USE
Take COVERSYL 8MG as advised by your physician. Take it before meals. Swallow this medicine, do not crush, or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF COVERSYL 8MG
COMMON
- low blood pressure
- dizziness
- feeling of spinning (vertigo)
- tingling or prickling sensation
- vision disturbances
- tinnitus (ringing sensation in the ears)
- cough
- shortness of breath
- gastrointestinal disorders (nausea, vomiting, abdominal pain, altered taste sensation or difficulty of digestion, diarrhoea, constipation)
- allergic reactions like skin rashes, itching
- muscle cramps
- feeling of weakness
- headache
UNCOMMON
- mood swings
- sleep disturbances
- dry mouth
- intense itching or severe skin rashes
- formation of fluid filled blister over the skin (pemphigoid)
- signs of kidney problems such as loss of appetite, decreased urinary output, fatigue
- impotence
- sweating
- signs of high levels of eosinophils in blood like weight loss, night sweats, cough
- fainting
- fast heartbeat
- signs of vasculitis (inflammation of blood vessels) such as joint pain and swelling, weight loss
- signs of increased sensitivity of the skin to sun like excessive sun rash and sun burn
- joint pain
- muscle pain
- chest pain
- general discomfort
- fever
- low blood sugar level (in diabetic patients)
- signs of high potassium levels like shortness of breath, chest pain, nausea, or vomiting
- signs of low sodium levels like whole body dizziness, fatigue, lethargy, weakness, or thirst
RARE
- signs of inappropriate antidiuretic hormone secretion like dark urine, decreased or absent urine output, feeling sick, muscle cramps, confusion, seizures (jerking movements of hands and legs)
- flushing
- decreased or absent urine output
- symptoms of acute renal failure like decreased urinary output, swelling due to fluid retention, nausea, fatigue, and shortness of breath.
Stop taking COVERSYL 8MG and contact your doctor immediately if you experience any of the following side effects:
- angioedema (painless swelling seen in face, lips, mouth, tongue, or throat)
- severe dizziness or sudden temporary loss of consciousness caused by low blood pressure
- irregular heartbeat or fast heartbeat, chest pain or heart attack
- signs of stroke like difficulty in walking, speaking, and understanding
- sudden wheezing, tightness in chest, difficulty in breathing (bronchospasm)
- inflammation of pancreas which may cause severe abdominal and back pain
- signs of hepatitis like jaundice (yellowing of skin and eyes)
- skin rash with red itchy patches on your face, arms or legs (erythema multiforme)
HOW TO MANAGE SIDE EFFECTS
Vomiting:
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks, and drinks. Avoid drinking too much liquid along with your meals. Consult your doctor if your symptom worsens.
Diarrhea:
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
Stomach pain:
Try to rest and relax. Try to have smaller and frequent meals. Keep a warm pad on your stomach. If the symptom does not improve, contact your doctor.
Dizziness:
When you feel dizzy, lie or sit down immediately. If you're experiencing a severe episode of vertigo, lie in a dark and quite place with eyes closed. Vehicle driving should be avoided if you experience frequent dizziness without warning. Talk to your doctor if the symptom worsens.
WARNING & PRECAUTIONS
PREGNANCY
COVERSYL 8MG is not recommended in early pregnancy and must not be taken when more than three months pregnant, as it may cause serious harm to the baby if used after 3rd month of pregnancy. Consult your doctor before taking COVERSYL 8MG.
BREASTFEEDING
COVERSYL 8MG is not recommended for use in breastfeeding women. Your doctor may prescribe an alternative medicine especially if you want to breast-feed when your baby is new-born or born prematurely. Consult your doctor for advice before taking COVERSYL 8MG.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizziness or weakness due to low blood pressure after taking COVERSYL 8MG. Consult your doctor before taking COVERSYL 8MG.
ALCOHOL
Avoid consumption of alcohol as it may increase the risk of low blood pressure, dizziness and lightheaded.
KIDNEY
COVERSYL 8MG is not recommended for use in patients with kidney artery stenosis (narrowing of blood vessels to one or both the kidneys). COVERSYL 8MG should be used in caution with patients having other kidney problems or under dialysis. Consult your doctor before taking COVERSYL 8MG.
LIVER
COVERSYL 8MG should be used with caution in patients having liver problems. Consult your doctor before taking COVERSYL 8MG.
ALLERGY
COVERSYL 8MG is not recommended for use if you are allergic to Perindopril or any other ACE inhibitors like captopril, enalapril.
HEART DISEASE
COVERSYL 8MG should be used in caution with patients having aortic stenosis (narrowing of the main blood vessel in heart), hypertrophic cardiomyopathy (condition in which heart muscle become thick abnormally) or any other heart problems. Before taking COVERSYL 8MG consult with your doctor.
OTHERS
COVERSYL 8MG is not recommended for use if you have:
- family history of angioedema
Before taking COVERSYL 8MG, inform your doctor if you have:
- primary aldosteronism
- collagen vascular disease such as systemic lupus erythematosus or scleroderma
- to undergo anaesthesia and/or major operation, LDL apheresis (which is removal of cholesterol from your blood by a machine), desensitization treatment to reduce the effects of an allergy to bee or wasp stings
- recent history of diarrhoea and vomiting
- diabetes
- salt restricted diet or using salt substitutes containing potassium, intolerance to some sugars
- dehydration problems
Use in pediatrics:
- COVERSYL 8MG is not recommended for use in children and adolescents (under 18 years of age). Talk to your doctor before taking COVERSYL 8MG.
Use in geriatrics:
- COVERSYL 8MG is used with caution in patients above 60 years of age. Before taking COVERSYL 8MG, consult your doctor.
INTERACTIONS
A. Drug - Drug interactions:
Before taking COVERSYL 8MG, inform your doctor if you are taking any of the following medicine:
- angiotensin II receptor blockers used to treat high blood pressure (Ex. Telmisartan, losartan, valsartan)
- aliskiren (medicine used to treat high blood pressure)
- diuretics such as furosemide, hydrochlorothiazide (used to treat oedema or high blood pressure)
- medicines that may increase blood potassium levels such as salt substitutes containing potassium, potassium-sparing diuretics (Ex. amiloride, spironolactone)
- antibiotic trimethoprim (medicine used to treat and prevent urinary tract infections)
- immunosuppressive agents such as ciclosporin or tacrolimus (used to prevent organ rejection after transplant)
- heparin (medicine used to prevent blood clot)
- non-steroidal anti-inflammatory drugs - medicines used to treat pain and inflammation (Ex. aspirin, ibuprofen)
- baclofen (medicine used for muscle spasm)
- medicines containing lithium (used to treat some types of depression)
- antidepressants such as citalopram, fluoxetine, paroxetine (medicine used to treat depression)
- estramustine (medicine used in cancer therapy)
- procainamide (used for treatment of irregular heartbeat)
- medicines such as ephedrine, noradrenaline or adrenaline used to treat low blood pressure, shock, or asthma
- vasodilators including nitrates like nitro-glycerine, isosorbide (medicine that make the blood vessels become wider)
- medicines which are most often used to treat diarrhoea (Ex. racecadotril)
- medicines used to treat to treat diabetes (insulin or metformin)
- allopurinol (medicine used to treat gout)
- gold salts (used to treat symptoms of rheumatoid arthritis)
- valsartan (medicine used to treat long-term heart failure)
- Mammalian target of rapamycin (mTOR inhibitors) like sirolimus, everolimus (medicines used to avoid rejection of transplanted organs)
Overdosage:
If you or anyone else accidentally take too much of COVERSYL 8MG, consult your doctor immediately or visit the nearby hospital. The most common symptom of overdose is low blood pressure (which can make you feel dizzy, or fainting).
SYNOPSIS
| Drug | : | Perindopril |
| Pharmacological Category | : | Angiotensin converting enzyme inhibitors |
| Therapeutic Indication | : | Hypertension, prevention of heart attack and stroke |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep COVERSYL 8MG out of reach of children
- Store at room temperature
FAQs ABOUT COVERSYL 8MG
Can COVERSYL 8MG be used to treat high blood pressure?
COVERSYL 8MG can be considered to treat high blood pressure. It contains perindopril which helps to relax the blood vessels and then normalize the blood pressure. Although, COVERSYL 8MG can treat high blood pressure, you doctor might treat you with other drugs depending upon your condition.
Can COVERSYL 8MG cause low blood pressure (hypotension)?
Yes. COVERSYL 8MG can causes fall in blood pressure especially during the first few days of treatment. Tell your doctor if you experience lightheaded or have any feeling of fainting. Your risk of low blood pressure may be higher if you don’t drink enough fluids and sweat heavily.
What should I avoid while taking COVERSYL 8MG?
Potassium supplements, potassium-containing salt substitutes and even high-potassium foods (Ex. Banana, avocado, potato) should be avoided by those taking perindopril, unless directed otherwise by their doctor.
What precautions do I need to follow while taking COVERSYL 8MG?
Patients taking COVERSYL 8MG must inform their doctor about their pre-existing disease conditions like kidney, heart, or liver problems. Consult your doctor immediately if you experience any unusual symptoms after taking COVERSYL 8MG.
What happens if I stop taking COVERSYL 8MG?
Do not stop taking COVERSYL 8MG without talking to your doctor first. Stopping this medicine suddenly can cause your blood pressure to spike and may increase the risk for heart attack or stroke.
REFERENCES
1. KD. Tripathi. Drugs Affecting Renin Angiotensin System. Essentials of medical pharmacology. Eighth edition. 2019. Page – 532-533.
2. Andrew Thomson and Mary Greenacre. Perindopril: the evidence of its therapeutic impact in hypertension. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. March 2007. [Accessed 13th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012553/
3. Enisa Hodzic, Ehlimana Pecar, Alen Dzubur, Elnur Smajic, Zorica Hondo, Daniela Delic and Edhem Rustempasic. Efficacy and Safety of Perindopril in Patients with Essential Hypertension. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. March 2020. [Accessed 13th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219713/
4. Tillomed LaboratoriesLtd. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Accessed 13th May 2022] https://www.medicines.org.uk/emc/files/pil.9913.pdf
5. Patheon Pharmaceuticals, Inc. U.S. Food & Drug Administration [Revised in March 2012] [Accessed 13th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020184s019lbl.pdf
USEFUL DIAGNOSTIC TESTS
- kidney function test
- electrolyte test
PRODUCT DETAILS
ALTERNATE BRANDS
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