INTRODUCTION

COVERSYL 8MG contains Perindopril which belongs to a group of medicines called ACE inhibitors. ACE inhibitors lowers blood pressure by widening blood vessels which allows the blood to flow more easily and reduces the effort needed to pump blood around the body. It is used to treat high blood pressure (hypertension), heart failure, kidney problems in diabetic patients with high blood pressure and also used if you have recently had a heart attack (myocardial infarction). Hypertension also called as high or raised blood pressure, is a condition in which the blood vessels have persistently raised pressure.

COVERSYL 8MG is long-acting angiotensin converting enzyme inhibitor. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. The inhibition of ACE results in reducing stress on the heart and relaxes blood vessel so that blood flows more smoothly and the heart can pump blood more efficiently.

Take COVERSYL 8MG exactly as prescribed by your doctor. The dose you take will depend on your age, other medications you are taking and whether you have any kidney or liver problems. Do not drive or operate machinery while taking this medicine, since it may cause dizziness or weakness. This medicine is not recommended for use in children and adolescents up to the age of 18 years, pregnant women and breastfeeding mothers. The common side effects are nausea, vomiting, headache and dizziness.

USES OF COVERSYL 8MG

• Treats blood pressure and heart failure
• Reduces the risk of cardiac events

HOW COVERSYL 8MG WORKS

COVERSYL 8MG works by widening the blood vessels and makes it easier for your heart to pump blood through the body.

DIRECTIONS FOR USE

Take COVERSYL 8MG as prescribed by your doctor. Swallow as a whole, do not crush or chew. It can be taken in the morning before a meal.

SIDE EFFECTS OF COVERSYL 8MG

HOW TO MANAGE SIDE EFFECTS

Nausea:

Stick to simple normal meals and do not eat rich or spicy foods.

Diarrhoea:

Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.

Stomach pain:

Place a warm water bottle on your abdomen. Soak in a warm bath. Drink plenty of clear fluids and water.

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, or sweet foods.

Constipation:

Add fruits, vegetables whole grains and other high-fiber foods to your normal diet.

WARNING & PRECAUTIONS

INTERACTIONS

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• valsartan, telmisartan, irbesartan and aliskiren (used for high blood pressure)
• racecadotril (used to treat diarrhea)
• sirolimus, everolimus, temsirolimus (used to avoid rejection of transplanted organs)
• sacubitril, eplerenone, spironolactone and procainamide (used to treat heart conditions)
• triamterene, amiloride (potassium-sparing drugs)
• trimethoprim/sulfamethoxazole
• lithium and medicines to treat psychotic disorders  
• ibuprofen (used for pain relief)
• insulin or metformin (to treat diabetes)
• baclofen (used to treat muscle stiffness)
• ciclosporin, tacrolimus (used to treat auto-immune disorder)
• trimethoprim (used to treat infections)
• estramustine (used in cancer therapy)
• allopurinol (used to treat gout)
• heparin (used to thin blood)
• ephedrine, nor adrenaline or adrenaline (used to treat low blood pressure)
• medicines to treat symptoms of rheumatoid arthritis

SYNOPSIS

MORE INFORMATION

Store at room temperature and keep out of reach of children.

FAQs ABOUT COVERSYL 8MG

Can COVERSYL 8MG be given in children?

This medicine is not recommended for children and adolescents above 18 years of age.

Does COVERSYL 8MG affect the kidneys?

It may decrease your kidney function, consult your doctor if your kidney function gets worse while you're taking it.

Can I stop taking COVERSYL 8MG?

Stopping this medicine suddenly may cause your blood pressure to rise and may increase your risk of heart attack and stroke. Consult your doctor for advice.

REFERENCES

1. KD Tripathi MD. Drugs affecting renin-angiotensin system and plasma kinins. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 503.

2. Randa Hilal- Dandan. Renin- Angiotensin. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 734.

3. Pfeffer MA, Opie LH. Inhibitors of the Renin-Angiotensin-Aldosterone System. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. Page - 143.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 1091-92.

5. Andrew Thomson and Mary Greenacre. Perindopril: the evidence of its therapeutic impact in hypertension: core evidence. March 31, 2007; [Accessed Nov 20, 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012553/

6. Accord Healthcare Limited, Electronic Medicines Compendium (EMC); [Revised June 2019] [Accessed Nov 20, 2020] https://www.medicines.org.uk/emc/files/pil.6117.pdf

7. IMED Pharma Ltd. [Revised Feb 2011] [Accessed Nov 20, 2020] https://www.hpra.ie/img/uploaded/swedocuments/2131677.PPA1463_024_001.661d9233-d801-4ae7-8260-00ef52396e21.000001Product%20Leaflet%20Approved.130619.pdf

8. Servier industries Limited, Electronic Medicines Compendium (EMC); [Revised Feb 2019] [Accessed Nov 20, 2020] https://www.medicines.org.uk/emc/files/pil.6224.pdf

USEFUL DIAGNOSTIC TESTS

• Kidney function test