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Drug Information

What is Perindopril used for?

Perindopril is used for the treatment of high blood pressure. It also prevents stroke or heart attack by lowering the blood pressure.

Perindopril may also be prescribed for other conditions as determined by the doctor.

How does Perindopril work?

Perindopril belongs to the class of drugs called angiotensin-converting enzyme (ACE) inhibitors. This drug acts by blocking the conversion of angiotensin-I to angiotensin-II and inhibiting the activity of angiotensin-converting enzyme. Thus, inhibition of ACE activity reduces blood pressure.

How to take Perindopril?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Take Perindopril as prescribed by your doctor.

Swallow the whole tablet. Do not crush or chew the tablet. Take the drug with or without food.

If you miss a dose of Perindopril, please take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

The overdose symptoms of Perindopril may include:

  • Trouble in breathing
  • Passing out
  • Severe dizziness
  • Unusual weakness

You must seek immediate medical care if you experience any of the above symptoms.

What are the drugs that interact with Perindopril?

Drugs that interact with Perindopril include the following:

  • Aliskiren
  • Alprazolam
  • Amiloride
  • Aripiprazole
  • Aspirin
  • Ibuprofen
  • Lithium
  • Olmesartan
  • Sacubitril

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Perindopril?

The following are the most common side effects of Perindopril:

  • Lightheadedness
  • Dry cough
  • Chills
  • Sneezing

The following are the severe side effects, and you may require immediate medical attention:

  • Loss of voice
  • Unusual tiredness
  • Confusion
  • Muscle cramps
  • Voice changes

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while taking Perindopril?

  • Avoid taking this medicine if you are allergic to Perindopril or similar drugs.
  • Do not drive or operate heavy machinery if Perindopril causes dizziness or blurred vision.
  • Take your first ever dose of Perindopril at bedtime, as it may cause dizziness.
  • Try getting up slowly while standing if you feel dizzy while on Perindopril.
  • Do not stop taking this medication abruptly unless instructed by the doctor.
  • Do not exceed the dose more than prescribed.
  • Be cautious while taking Perindopril if you have any respiratory disorders, kidney or liver impairment.
  • Drink adequate fluids while taking Perindopril.
  • Avoid consumption of alcohol as it may worsen the side effects of Perindopril.

You are advised not to take Perindopril if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking Perindopril?

  • Tell your doctor if you have any history of heart, liver, and kidney diseases.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • Notify the doctor if you are pregnant or breastfeeding.

Frequently asked questions about Perindopril

  1. Do I need to be monitored for any laboratory parameters while taking Perindopril?
  2. Yes. Blood pressure and blood electrolyte levels must regularly be monitored while using Perindopril.

  3. What are the contraindications of Perindopril?
  4. Perindopril is contraindicated in idiopathic angioedema, hyperkalemia, neutropenia, bone marrow depression, renal artery stenosis and giant hives.

  5. Should I follow any special dietary instructions while taking Perindopril?
  6. Yes. You must follow a diet low in sodium and potassium while on Perindopril. Make sure that you are eating a healthy and well-balanced diet while taking the drug. 

  7. Can I take Perindopril while using Atenolol?
  8. No. Use of Perindopril with other anti-hypertensive drugs such as Atenolol may increase the risk of side effects. Consult the doctor before using any other drug while on Perindopril. 


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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