INTRODUCTION

COSVATE NM LOTION is a combination of Clobetasol, Miconazole and Neomycin which belongs to the group of medicines called Corticosteroids, Antifungals and Antibiotics. It is used to treat resistant dermatoses (skin infections) with secondary bacterial or fungal infection.

COSVATE NM LOTION is not recommended for use in patients with rosacea, acne vulgaris, perioral dermatitis, perianal and genital pruritus, viral infections (ex. herpes simplex, chickenpox) and perforated eardrum. Contact your doctor before applying. COSVATE NM LOTION should be used with caution in patients with liver or kidney disease. Contact your doctor before applying.

COSVATE NM LOTION is generally not recommended for use in pregnancy unless considered clearly necessary. COSVATE NM LOTION should be used with caution in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before applying. COSVATE NM LOTION is not recommended for use in children under 2 years of age. Contact your doctor before applying.

Dosage adjustment is not required for COSVATE NM LOTION in the geriatric population. However, greater sensitivity of some older individuals cannot be ruled out. Contact your doctor before applying. The most common side effects of this medicine are skin rash, itching, redness, burning sensation and contact dermatitis. Contact your physician if any of the symptoms worsen.

USES OF COSVATE NM LOTION

• Used to treat resistant dermatoses (skin infections) with secondary bacterial or fungal infection

HOW COSVATE NM LOTION WORKS

COSVATE NM LOTION helps to treat infection, where Clobetasol have anti-inflammatory, antipruritic, and vasoconstrictive properties, which blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen, and itchy. Miconazole belongs to antifungal which stops the growth of fungi while Neomycin belongs to antibiotic which stops the growth of bacteria in the skin.

DIRECTIONS FOR USE

Apply COSVATE NM LOTION as directed by your physician. It is for external use only. Wash your hands with soap and water and apply a thin layer of the medicine to the affected area of the skin and rub it gently. Avoid contact with eyes, face, groin or in the skin folds.

SIDE EFFECTS OF COSVATE NM LOTION

HOW TO MANAGE SIDE EFFECTS

Skin Rash Or Itching

Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if itching worsens.

WARNING & PRECAUTIONS

PREGNANCY

Monitoring required

COSVATE NM LOTION is not recommended for use in pregnancy unless considered clearly necessary. Contact your doctor before applying.

BREASTFEEDING

Use with Caution

COSVATE NM LOTION should be used with caution in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before applying.

KIDNEY

Use with Caution

COSVATE NM LOTION should be used with caution in patients with kidney disease. Contact your doctor before applying.

LIVER

Use with Caution

COSVATE NM LOTION should be used with caution in patients with liver disease. Contact your doctor before applying.

ALLERGY

Contraindicated

Do not use COSVATE NM LOTION if you are allergic to Clobetasol, Miconazole, Neomycin, or to any other ingredients of this medicine.

USE IN PEDIATRICS

Contraindicated

COSVATE NM LOTION is not recommended for use in children under 2 years of age. Contact your doctor before applying.

USE IN GERIATRICS

Use with Caution

Dosage adjustment is not required for COSVATE NM LOTION in the geriatric population. However, greater sensitivity of some older individuals cannot be ruled out. Contact your doctor before applying.

INTERACTIONS

A. Drug-Drug interactions:

Before applying COSVATE NM LOTION tell your doctor if you are taking,

• ritonavir (medicines used for HIV infections)
• itraconazole (medicines used for fungal infections)
• amikacin, gentamicin (medicines used for bacterial infections)
• neuromuscular blocking agents like atracurium, pancuronium (medicines used in anaesthesia)
• warfarin (medicines used to treat or prevent blood clots)

Overdosage:

If you or anyone else accidentally uses too much of COSVATE NM LOTION, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Store COSVATE NM LOTION below 25°C

FAQs ABOUT COSVATE NM LOTION

Q: What are the possible side effects of applying COSVATE NM LOTION?

A: The most common side effects of this medicine are skin rash, urticaria, itching, redness, burning sensation and contact dermatitis. Contact your physician if any of the symptoms worsen.

Q: Can I use COSVATE NM LOTION in children?

A: COSVATE NM LOTION is not recommended for use in children under 2 years of age. Contact your doctor before applying.

Q: For what conditions COSVATE NM LOTION is used?

A: COSVATE NM LOTION is used to treat resistant dermatoses (skin infections) with secondary bacterial or fungal infection.

Q: Does COSVATE NM LOTION cause itching on the skin?

A: Yes, COSVATE NM LOTION may cause skin itching at the site of application as a temporary side effect. However, if the itching persists or worsens, consult your doctor for advice.

Q: Can I stop using COSVATE NM LOTION when my symptoms are relieved?

A: No, do not stop using COSVATE NM LOTION and complete the full course of treatment, even if you feel better. Your symptoms may improve before the infection is completely cured.

Q: Who should not use COSVATE NM LOTION?

A: COSVATE NM LOTION is not recommended for use in patients with rosacea, acne vulgaris, perioral dermatitis, perianal and genital pruritus, viral infections (ex. herpes simplex, chickenpox), perforated eardrum. Contact your doctor before applying.

REFERENCES

1. K.D. Tripathi. Drugs acting on the skin and mucous membrane, Antifungal Drugs & Aminoglycoside Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 895, 792, 750.

2. Bethesda (MD). Clobetasol. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/5311051

3. Bethesda (MD). Miconazole. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/4189

4. Bethesda (MD). Neomycin. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Neomycin

5. Blue Cross labs. Clobetasol, Miconazole and Neomycin. [Revised on May 2020] [Accessed on 24th June 2022] https://www.bluecrosslabs.com/img/sections/SONADERM-NM-CREAM.pdf