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INTRODUCTION

COSVATE G CREAM is a combination of Clobetasol and Gentamicin which belongs to the group of medicines called Corticosteroids and Antibiotics respectively. It is used to treat bacterial infections and inflammations of the skin.

During the treatment your doctor might regularly examine your skin to avoid any untoward side effects.

Avoid smoking while using COSVATE G CREAM. Consult your doctor before using this medicine.

COSVATE G CREAM is not recommended for use in children (ages less than 1 year). Before using COSVATE G CREAM, inform your doctor if you have skin conditions like fungal infections, severe flushing on and around your nose, spotty red rash around your mouth, infected or itchy skin around the genitals.

COSVATE G CREAM should be used with caution in pregnant women. COSVATE G CREAM is not recommended for use in breastfeeding women.

The most common side effects of using COSVATE G CREAM are burning, pain, irritation or itching where the medicine is applied. Contact your doctor if any of the side effects worsen.

USES OF COSVATE G CREAM

  • Used to treat bacterial skin infections

HOW COSVATE G CREAM WORKS

COSVATE G CREAM treats affected skin where Clobetasol induces certain proteins (lipocortins), that control the production of inflammatory mediators like prostaglandins and leukotrienes, thus reducing inflammation, and Gentamicin binds to 30s ribosomal subunit, disrupting mRNA translation, resulting in the formation of shortened or non-functional proteins.

DIRECTIONS FOR USE

Apply COSVATE G CREAM as directed by your physician. It is for external use only. Apply a thin layer of the medicine to the affected area of the skin and rub it gently. Avoid contact with eyes. Your doctor will decide the right dose depends on your age, body weight and severity of infection.

SIDE EFFECTS OF COSVATE G CREAM

COMMON

  • burning, pain, irritation or itching (application site reactions)

UNCOMMON

  • skin thinning that may cause stretch marks
  • blood vessels under the skin surface may become more visible

RARE

Stop using COSVATE G CREAM and consult your doctor immediately if you experience any of the following side effects:

  • rounding of the face
  • increased risk of infection
  • dryness of skin
  • easy damage or wrinkling of the skin
  • worsening of skin problems (generalized rash or swelling)
  • raised bumps with pus under the skin
  • blurred vision or other visual disturbances
  • new bone pain or worsening of previous bone symptoms
  • overgrowth of non-susceptible organisms like fungi, irritation, sensitization, or superinfection

WARNING & PRECAUTIONS

PREGNANCY
Use with Caution

COSVATE G CREAM should be used with caution in pregnant women. Consult your doctor before using the medicine.

BREASTFEEDING
Contraindicated

COSVATE G CREAM is not recommended for use in breastfeeding women. Consult your doctor before using the medicine.

ALLERGY
Contraindicated

Do not use COSVATE G CREAM if you are allergic to Clobetasol, Gentamicin, or any other ingredients of this medicine.

OTHERS

COSVATE G CREAM is not recommended for use if you:

  • have acne
  • have rosacea (sudden reddening of skin on and around your nose)
  • have perioral dermatitis (red spotty rash around your mouth)
  • have itching around genital parts
  • have any infection
  • have itchy skin without inflammation
  • have widespread plaque psoriasis

Before using COSVATE G CREAM inform your doctor if you:

  • have psoriasis

Use in Pediatrics:

COSVATE G CREAM is not recommended for use in children (less than 1 year of age). Consult your doctor before using the medicine.

INTERACTIONS

A. Drug-Drug interactions:

Before using COSVATE G CREAM, inform your doctor if you are taking any of the following medicine:

  • other medicines used to treat inflammation (Ex. prednisolone, hydrocortisone)
  • medicines used to control your immune system (Ex. ciclosporin, tacrolimus)

Overdosage:

If you or anyone else accidentally applies too much of COSVATE G CREAM, contact your doctor immediately or visit nearby hospital.

SYNOPSIS

Drug :   Clobetasol, Gentamicin
Pharmacological Category :   Corticosteroid, Antibiotics
Therapeutic Indication :   Bacterial skin infections           
Dosage Forms :   Cream

MORE INFORMATION

  • Keep COSVATE G CREAM out of reach of children
  • Do not store above 30°C

FAQs ABOUT COSVATE G CREAM

Q: For how long can I use COSVATE G CREAM?

A: Use COSVATE G CREAM for as long as your doctor advises you to. If you use it over a long time or in large amounts it may increase your chances of getting side effects, and your skin may get more sensitive to the medicine.

Q: What special precautions should I take while using COSVATE G CREAM?

A: Take special care if you are going to use COSVATE G CREAM near your eyes. Do not smoke or go near flames as it may cause severe burns. Consult your doctor in case of any concerns.

Q: What if I accidently get COSVATE G CREAM in my eye?

A: If you accidentally get COSVATE G CREAM in your eye, immediately wash it out with plenty of water. If you begin to have any problems with your sight or your eye is hurting, contact your doctor immediately.

Q: Can I stop using COSVATE G CREAM?

A: Do not stop using COSVATE G CREAM without asking your doctor as abrupt discontinuation might worsen your condition. If you have any more doubts regarding the use of this medicine, ask your doctor.

Q: What if I forget to apply a dose of COSVATE G CREAM?

A: If you forget to apply a dose of COSVATE G CREAM, do it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not apply extra medicine to make up for a forgotten dose.

Q: Can COSVATE G CREAM be used on infants?

A: No. COSVATE G CREAM is not recommended for children (below 1 year of age). Your doctor will decide the correct dose or select a suitable alternative therapy for your child.

Q: Can COSVATE G CREAM be used in breastfeeding?

A: COSVATE G CREAM is not recommended for use during breast feeding. Do not apply it on your breast area so that the baby does not accidentally ingest the medicine.

REFERENCES

1. KD. Tripathi. Aminoglycosides Antibiotics. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 747.

2. PubChem Compound Summary for CID 5311051, Clobetasol. National Center for Biotechnology Information. June 2022. [Accessed on 27th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Clobetasol#section=Mechanism-of-Action

3. Bruno J. Chaves; Prasanna Tadi. Gentamicin. StatPearls [Internet]. StatPearls Publishing. May 2022. [Accessed on 27th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK557550/#article-22211.s3

4. Glaxo Operations UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 27th June 2022] https://www.medicines.org.uk/emc/files/pil.939.pdf

5. Padagis Israel Pharmaceuticals Ltd. Gentamicin. [Revised in September 2021] [Accessed on 27th June 2022] file:///C:/Users/NMSLAP468/Downloads/20210925_4cfbe37e-11d6-46fc-b287-0561387b17b7.pdf

6. Wellona Pharma. Clobetasol propionate + Gentamicin. [Accessed on 27th June 2022] https://wellonapharma.com/product/finished/clobetasol-propionate-and-gentamicin-cream

USEFUL DIAGNOSTIC TESTS

  • Patch testing

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    40 g
    Ingredient
    CLOBETASOL PROPIONATE 0.05%+GENTAMICIN 0.1%
    Hsn Code
    30043200
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Cosvate G Cream 25gm

Cosvate G Cream 25gm Mkt: Oaknet Healthcare Pvt Ltd

M.R.P.: Rs.25.97
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