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INTRODUCTION
CORDARONE X TABLET contains Amiodarone which belongs to the group of medicines called Antiarrhythmics. It is used to treat uneven or fast heartbeats (like atrial flutter or atrial fibrillation), fast heartbeats which may happen suddenly and may be uneven only when other medicines either have not worked or cannot be used. It also treats Wolff-Parkinson-White Syndrome (unusually fast heartbeats). Your doctor might want you to keep out of direct sunlight while taking CORDARONE X TABLET and for a few months after you have finished taking it.
Avoid consumption of alcohol and grapefruit juice during treatment with CORDARONE X TABLET. CORDARONE X TABLET is not recommended for use if you have signs of an allergic reaction including (a rash, swallowing or breathing difficulties, swelling of your lips, face, throat or tongue).
It is also not recommended to use if you have slower than usual heartbeat (called ‘sinus bradycardia’) or an illness called sino-atrial heart block, other problems with your heartbeat without a pacemaker fitted, are going to have a heart transplantation or have thyroid problems.
Before taking CORDARONE X TABLET, inform your doctor if you have heart failure, liver, lung problems or asthma, eyesight problems (optic neuritis), are about to have any surgery, have a pacemaker or implantable cardioverter defibrillator (ICD). Also inform your doctor if you have intolerance to certain sugars, blistering or peeling of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever (Stevens-Johnson syndrome), layers of the skin peeling off to leave large areas of raw exposed skin over the body (Toxic Epidermal Necrolysis).
CORDARONE X TABLET is not recommended for pregnant or breastfeeding women. It is not recommended for use in children and adolescents below 18 years of age. CORDARONE X TABLET should be used with caution in elderly patients above 65 years of age. The most common side effects of taking CORDARONE X TABLET are nausea, vomiting, change in taste, constipation, sleeping problems. Consult your doctor if any of the symptoms worsen.
USES OF CORDARONE X TABLET
It is used to treat:
- sudden, fast or uneven heartbeats (atrial flutter or atrial fibrillation) when other medicines either have not worked or cannot be used
- Wolff-Parkinson-White Syndrome
HOW CORDARONE X TABLET WORKS
CORDARONE X TABLET works by blocking certain electrical signals and reducing the excitability of cardiac tissues which prevents the initiation and conduction of any new impulses in the heart that cause irregular heartbeats, thus making your heartbeat return to normal.
DIRECTIONS FOR USE
Take CORDARONE X TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF CORDARONE X TABLET
COMMON
- nausea, vomiting, constipation, change in taste
- tanning more easily in the sun
- slightly slower heartbeat
- nightmares, sleep problems
- scaly and itchy rash
- reduced sex drive
UNCOMMON
- dry mouth
RARE
Stop taking CORDARONE X TABLET and consult your doctor immediately if you experience any of the following side effects:
- allergic reaction (rash, swollen eyelids, face, lips, throat or tongue)
- Stevens-Johnson syndrome (blistering or peeling of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever)
- toxic epidermal necrolysis (severe blistering rash in which layers of the skin may peel off, feeling generally unwell, fever, chills and muscle pain)
- bullous dermatitis (fluid filled blisters on the skin)
- flu like symptoms and a rash on the face followed by an extended rash with a high temperature, enlarged lymph nodes (DRESS)
- yellowing of the skin or eyes (jaundice), feeling tired or sick, loss of appetite, stomach pain or high temperature. (signs of liver problems or damage)
- shortness of breath or difficulty breathing , tightness in the chest, coughing which will not go away, wheezing, weight loss and fever ( inflammation of your lungs)
- heartbeat becomes even more uneven or erratic (can lead to a heart attack)
- feeling numb or weak, tingling or burning feelings in any part of the body
- feeling extremely restless or agitated, weight loss, increased sweating and being unable to stand the heat (signs of hyper-thyroidism)
- unable to stand the cold, constipation and aching muscles (signs of hypo-thyroidism)
- trembling when you move your arms or legs
- blue or gray marks on parts of your skin exposed to sunlight
- muscle cramps, stiffness or spasm
- blurred eyesight or seeing a coloured halo in dazzling light
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Stick to simple meals. Avoid eating oily or spicy foods. Drink more water. Consult your doctor if symptoms don't show improvement.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly. Consult your doctor if symptoms don't show improvement.
Rash:
Applying a cold compress, cool showers or damp cloth, cold water can bring immediate relief to swelling and reduce itching. Consult your doctor if symptoms don't show improvement.
Tanning:
Make sure you use high factor sun cream. Always wear a hat and clothes which cover your arms and legs. Consult your doctor if symptoms don't show improvement.
WARNING & PRECAUTIONS
PREGNANCY
CORDARONE X TABLET is generally not recommended for use in pregnant women or women planning to have a baby. Consult your doctor before taking CORDARONE X TABLET.
BREASTFEEDING
CORDARONE X TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking CORDARONE X TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel like your eyesight is blurry after taking CORDARONE X TABLET.
ALCOHOL
Avoid consumption of alcohol during treatment with CORDARONE X TABLET, as it may increase the chances of liver problems.
LIVER
CORDARONE X TABLET should be taken with caution in patients with liver disease. Consult your doctor before taking CORDARONE X TABLET.
ALLERGY
Do not take CORDARONE X TABLET if you are allergic to Amiodarone, iodine or any other ingredients of this medicine.
LUNGS
CORDARONE X TABLET should be taken with caution in patients with asthma or other lung disease. Consult your doctor before taking CORDARONE X TABLET.
HEART DISEASE
CORDARONE X TABLET is not recommended for use if you have slower than usual heartbeat (called ‘sinus bradycardia’) or an illness called sino-atrial heart block, other problems with your heartbeat without a pacemaker fitted or are going to have a heart transplantation.
CORDARONE X TABLET should be taken with caution in patients with heart failure or if you have a pacemaker or implantable cardioverter defibrillator (ICD). Consult your doctor before taking CORDARONE X TABLET.
OTHERS
CORDARONE X TABLET is not recommended for use if you:
- have signs of an allergic reaction include (a rash, swallowing or breathing difficulties, swelling of your lips, face, throat or tongue)
- history of thyroid problems
Before taking CORDARONE X TABLET, inform your doctor if you:
- have any issues with your eyesight (optic neuritis)
- are about to have any surgery
- have Stevens-Johnson syndrome (blistering or peeling of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever)
- have toxic epidermal necrolysis (severe blistering rash in which layers of the skin may peel off, feeling generally unwell, fever, chills and muscle pain)
- intolerance to certain sugars
Use in pediatrics:
CORDARONE X TABLET is generally not recommended for use in children and adolescents below 18 years of age. Consult your doctor before taking it.
Use in geriatrics:
CORDARONE X TABLET should be used with caution in elderly patients above 65 years of age. Dose will be adjusted by your doctor. Consult your doctor before taking CORDARONE X TABLET.
INTERACTIONS
A. Drug - Drug interactions:
Before taking CORDARONE X TABLET, inform your doctor if you are taking any of the following medicine:
- other medicines used to treat uneven heartbeats (Ex. sotalol, quinidine, procainamide, disopyramide, flecainide or bretylium)
- medicines used to treat infections (Ex. intra-venous erythromycin, co-trimoxazole, moxifloxacin, pentamidine, clarithromycin, ciprofloxacin, ofloxacin or levofloxacin)
- medicines used to treat schizophrenia (Ex. chlorpromazine, fluphenazine, thioridazine, pimozide, haloperidol, sertindole or amisulpride)
- medicines used to treat other mental illnesses (Ex. lithium, doxepin, maprotiline or amitriptyline)
- medicines used to treat malaria (Ex. quinine, mefloquine, chloroquine or halofantrine)
- medicines used to treat hay fever, rashes or other allergies (Ex. terfenadine, astemizole or mizolastine)
- medicines used to treat hepatitis C (Ex. sofosbuvir, daclatasvir, simeprevir or ledispasvir)
- medicine used to treat heart problems (such as high blood pressure, chest pain or high cholesterol) (Ex. Propranolol, diltiazem, verapamil, furosemide, simvastatin, atorvastatin or digitalis)
- medicines used to treat constipation (Ex. bisacodyl or senna)
- medicines for high cholesterol (statins) (Ex. simvastatin or atorvastatin)
- medicines used to treat fungal infection (Ex. Amphotericin IV)
- medicines used to treat inflammation (Ex. hydrocortisone, betamethasone or prednisolone)
- water tablets (diuretics like chlorthalidone) to reduce blood pressure
- medicines used during surgery (Ex. lidocaine, midazolam or high dose oxygen)
- medicines used to test some hormone problems (Ex. Tetracosactide)
- medicines used to prevent rejection of transplants (Ex. Ciclosporin, tacrolimus and sirolimus)
- medicines used to treat impotence (Ex. sildenafil, tadalafil or vardenafil)
- medicines used to treat pain (Ex. fentanyl)
- medicines used for migraines (Ex. ergotamine)
- medicines used to treat gout (Ex. Colchicine)
- medicines used to stop your blood from clotting (Ex. Warfarin, dabigatran)
B. Drug - Food interaction:
Avoid drinking grapefruit juice while taking CORDARONE X TABLET as it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally takes too much CORDARONE X TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling dizzy, faint or tired, confusion, slow heartbeat, damage to the liver or nausea.
SYNOPSIS
| Drug | : | Amiodarone |
| Pharmacological Category | : | Antiarrhythmic |
| Therapeutic Indication | : | Arrhythmias, Wolff-Parkinson-White Syndrome |
| Dosage Forms | : | Tablet, Injection |
MORE INFORMATION
- Keep CORDARONE X TABLET out of reach of children
- Do not store above 25°C
FAQs ABOUT CORDARONE X TABLET
What is CORDARONE X TABLET used for?
CORDARONE X TABLET is used to treat uneven or fast heartbeats (like atrial flutter or atrial fibrillation), fast heartbeats which may happen suddenly and may be uneven only when other medicines either have not worked or cannot be used. It also treats Wolff-Parkinson-White Syndrome (unusually fast heartbeats).
How does CORDARONE X TABLET work?
CORDARONE X TABLET works by blocking certain electrical signals and reducing the excitability of cardiac tissues which prevents the initiation and conduction of any new impulses in the heart that cause irregular heartbeats, thus making your heartbeat return to normal.
Can CORDARONE X TABLET make my skin sensitive to the sun?
Yes. your skin will become much more sensitive to the sun after taking CORDARONE X TABLET and may burn, tingle or severely blister. Do not expose yourself to direct sunlight while taking this medicine and for a few months after you have finished taking it. Use high factor sun cream without fail. Always wear a hat and clothes which cover your whole body.
What should I avoid while taking CORDARONE X TABLET?
Avoid drinking grapefruit juice while taking CORDARONE X TABLET as it may increase the risk of side effects. Avoid consumption of alcohol during treatment with CORDARONE X TABLET, as it may increase the chances of liver problems.
Can CORDARONE X TABLET cause stomach problems?
Yes, CORDARONE X TABLET can cause nausea, vomiting, constipation or diarrhea as a common side effect. Consult your doctor if symptoms worsens or does not show any improvement.
REFERENCES
1. KD. Tripathi. Antiarrhythmic Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 533.
2. Ruben ML Colunga Biancatelli, Viviana Congedo, Leonardo Calvosa, Marco Ciacciarelli, Alessandro Polidoro and Luigi Iuliano. Adverse reactions of Amiodarone. National library of medicine, National center for biotechnology information. Pubmed Central. 2019. [Accessed on 19th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689516/
3. Hugo Van Herendael and Paul Dorian. Amiodarone for the treatment and prevention of ventricular fibrillation and ventricular tachycardiaNational library of medicine, National center for biotechnology information. Pubmed Central. 2010. [Accessed on 19th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922307/
4. S.C. Zentiva S.A. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 19th April 2022] https://www.medicines.org.uk/emc/files/pil.2815.pdf , https://www.medicines.org.uk/emc/product/2815/smpc
USEFUL DIAGNOSTIC TESTS
- Liver Function Test (LFT)
- Thyroid Function Test (TFT)
- Complete Blood Count (CBC)
- Chest X-Ray
- Electrocardiogram (ECG)
- Eye tests
- Blood pressure test
AUTHOR DETAILS
Written By Dr. Shruthi M R, BDS
Last updated on 12 Jan 2023 | 09:57 AM(IST)
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.