INTRODUCTION

CORADON MR 35 TABLET contains Trimetazidine which belongs to the group of medicines called Anti-anginal agents. It is used in adult patients for the management of angina pectoris (chest pain caused by a heart disease) along with other medicines. It protects the heart cells from the effects of a reduced oxygen supply during an episode of angina.

Angina is a type of chest pain caused by reduced blood flow to the heart. It is a symptom of an underlying coronary heart disease (narrowing or blockage of blood vessels that carry blood and oxygen to heart). It is characterized by sudden, sharp, and severe pain, pressure, or discomfort in chest radiating to the left shoulder. The discomfort can also be felt in jaw, neck, back, or abdomen. Some people may also suffer from shortness of breath or fatigue.

CORADON MR 35 TABLET is not recommended for use if you have parkinson disease (a brain disorder that affects movement (trembling, rigid posture, slow movements and a shuffling, unbalanced walk) or severe kidney problems.

This medicine should be used cautiously in elderly patients (above 75 years), pregnant, and breast-feeding mothers. Do not drive or operate any machinery if you feel dizzy after taking CORADON MR 35 TABLET.

The common side effects associated with CORADON MR 35 TABLET are dizziness, headache, abdominal pain, diarrhoea, vomiting, indigestion, feeling of being sick, rashes, itching, hives, and feeling of weakness. Consult your doctor if the condition persists for long or worsens.

USES OF CORADON MR 35 TABLET

• Used to treat ischemic heart disease, angina pectoris and squeals of infarction

HOW CORADON MR 35 TABLET WORKS

CORADON MR 35 TABLET works by optimising metabolism of fatty acids and glucose, thereby allowing more blood flow and oxygen supply to the heart. It also reduces thickening and scarring of heart tissue. This results in reducing chest pain due blood vessel narrowing or blocking.

DIRECTIONS FOR USE

Take CORADON MR 35 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.

SIDE EFFECTS OF CORADON MR 35 TABLET

HOW TO MANAGE SIDE EFFECTS

Dizziness:

CORADON MR 35 TABLET may cause dizziness which can managed by lying down  until the dizziness passes and get up slowly. Do not bend  down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol, or smoking. Consult your doctor if the condition persists for long or gets worsened.

Headache:

CORADON MR 35 TABLET may cause headache which can be managed by taking lots of water and rest. Do not skip meals. Do not strain your eyes for long durations, such as watching screen. Avoid taking alcohol. Consult your doctor if the condition persists for long or gets worsened.

Indigestion:

CORADON MR 35 TABLET may cause indigestion which can be managed by reducing tea, coffee, aerated drinks, or alcohol. Do not eat 3 to 4 hours before going to bed. Avoid smoking and having spicy or fatty food. Consult your doctor if the condition persists for long or gets worsened.

WARNING & PRECAUTIONS

PREGNANCY

CORADON MR 35 TABLET should not be taken during pregnancy unless clearly necessary. Consult your doctor before taking.

BREASTFEEDING

CORADON MR 35 TABLET is not recommended in breastfeeding women. Consult your doctor before taking.

DRIVING AND USING MACHINES

Do not drive or operate any machinery if you feel dizzy after taking CORADON MR 35 TABLET.

ALCOHOL

Avoid consumption of alcohol while taking CORADON MR 35 TABLET because it may make you dizzier.

KIDNEY

CORADON MR 35 TABLET is not recommended for use if you are having kidney related problems. Consult your doctor before taking.

ALLERGY

Do not take CORADON MR 35 TABLET if you are allergic to Trimetazidine or any other ingredient in this medicine. Consult your doctor before taking.

HEART DISEASE

CORADON MR 35 TABLET should be used with caution in patients with heart diseases. This medicine does not cure sudden angina attacks and should not be used as a treatment for unstable or heart attack. Moreover, it may cause palpitations (irregular heartbeats). Consult your doctor before taking.

INTERACTIONS

A. Drug-Drug interactions:

Before taking CORADON MR 35 TABLET, inform your doctor if you are taking any other medicines including medicines obtained without the prescription.

Overdosage:

If you or anyone else accidently takes too much of CORADON MR 35 TABLET, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep CORADON MR 35 TABLET out of reach of children
• Store at room temperature

FAQs ABOUT CORADON MR 35 TABLET

What is the action of CORADON MR 35 TABLET?

CORADON MR 35 TABLET works by optimising metabolism of fatty acids and glucose, thereby allowing more blood flow and oxygen supply to heart. It also reduces thickening and scarring of heart tissue. This results in reducing chest pain due blood vessel narrowing or blocking. Consult your doctor before taking.

Is CORADON MR 35 TABLET good for heart?

Yes, CORADON MR 35 TABLET is good for heart in adult patients suffering from angina pectoris (chest pain caused by a heart disease). It protects the heart cells from the effects of a reduced oxygen supply during an episode of angina. Consult your doctor before taking.

Can CORADON MR 35 TABLET lower blood pressure?

CORADON MR 35 TABLET  can cause fall in blood pressure on standing-up occasionally, thereby causing dizziness, light headiness or fainting, malaise (feeling of being unwell), dizziness, and fall flushing. Contact your doctor or nearby hospital immediately.

How long should I take CORADON MR 35 TABLET?

Take CORADON MR 35 TABLET as advised by your physician. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition. Consult your doctor before you stop taking your medicine.

What are the common side effects of CORADON MR 35 TABLET?

The common side effects associated with CORADON MR 35 TABLET intake are dizziness, headache, abdominal pain, diarrhoea, vomiting, indigestion, feeling of being sick, rashes, itching, hives, and feeling of weakness. Consult your doctor if the condition persists for long or worsens.

How to take CORADON MR 35 TABLET?

Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.

What if I forget to take CORADON MR 35 TABLET dose?

If you forget to take one or more CORADON MR 35 TABLET doses, do not take a double dose to make up for a forgotten dose as it may lead to serious consequences. Consult your doctor in such conditions.

When to stop taking CORADON MR 35 TABLET?

Stop taking CORADON MR 35 TABLET and consult your doctor immediately if you experience signs of low blood pressure (dizziness, light headiness or fainting, malaise, dizziness, and fall flushing), low platelet count (frequent bruising, superficial bleeding, and prolonged bleeding from wounds), low white blood cell count that increases vulnerability to infections.

REFERENCES

1. KD. Tripathi. Corticosteroids. Essentials of medical pharmacology. Seventh edition. 2013. Page 553-554.

2. Yuri M. Pozdnyakov. Clinical Acceptability Of Trimetazidine Modified Release 80mg Once Daily Versus Trimetazidine Modified-Release 35mg Twice Daily In Stable Angina Pectoris. National Library of Medicine. PubMed Central. June 2018. [Assessed 20th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464521

3. Kirti Gupta, Sneha Pandey, Newly Bagang, Kamalpreet Mehra, Gaaminepreet Singh. Trimetazidine an emerging paradigm in renal therapeutics: Preclinical and clinical insights. National Library of Medicine. PubMed Central. November 2021. [Assessed 20th June 2022] https://pubmed.ncbi.nlm.nih.gov/34774496/

4. Agustín Ciapponi,corresponding author Rudolf Pizarro, Jeff Harrison. Trimetazidine for stable angina. National Library of Medicine. PubMed Central. March 2017. [Assessed 20th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464521/

5. European Medicine Agency. Assessment Report for trimetazidine containing medicinal products. [Revised in September 2012] [Accessed 20th June 2022] https://www.ema.europa.eu/en/documents/referral/trimetazidine-article-31-referral-assessment-report_en.pdf

6. Servier (Ireland) Industries Ltd. Health Product Regulatory Authority. [Revised in February 2021] [Accessed 20th June 2022] http://www.hpra.ie/img/uploaded/swedocuments/fc314b85-1fe6-463e-a6f1-33c49375b2a4.pdf

7. VIANEX S.A. Health Product Regulatory Authority. [Revised in April 2016] [Accessed 20th June 2022] https://www.hpra.ie/img/uploaded/swedocuments/2175323.PPA0465_122_001.7fe02c5a-e650-4c76-9bbe-6ed7fb2b4ef6.000001Vastarel%2020mg%20Tabs%20PIL.160425.pdf

AUTHOR DETAILS

Written By Dr. Janet.C, Pharm.D
Last updated on 16 Nov 2022 | 12:34 PM(IST)