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COMFORA 100mg Capsule 90's
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INTRODUCTION
COMFORA 100MG contains Pentosan polysulphate that belongs to the group of medicines called Anticoagulants. It is used to treat bladder pain or discomfort in interstitial cystitis. Interstitial cystitis is a long-standing painful condition in which the bladder wall becomes painful and irritated. It is characterized by symptoms such as bladder pressure, bladder pain, pelvic pain, and persistent urgency to urinate.
Pentosan polysulphate works by strengthening and modifying glycosaminoglycans (a type of complex carbohydrates present in the walls of urinary bladder) which provides relief from painful bladder filling and facilitates proper emptying of bladder thus treating symptoms of interstitial cystitis. Your doctor may advise you for regular eye examination while taking this medicine.
COMFORA 100MG is not recommended for use in patients allergic to Pentosan polysulphate and in patients suffering from bleeding problems (other than menstrual bleeding). It should be used with caution in patients with history of retinal or eye problems/aneurysms, haemophilia, gastrointestinal tract problems (such as ulcerations, polyps, or diverticula), hepatic or renal insufficiencies. It is not recommended for use in pregnant and breastfeeding women. It is also not recommended for use in children and adolescents (below 18 years of age). Consult child’s doctor for advice.
The common side effects associated with the use of COMFORA 100MG are hair loss, diarrhoea, nausea, headache, rash, indigestion, abdominal pain, and or dizziness. Contact your doctor or visit nearby hospital if any of the symptom worsens.
USES OF COMFORA 100MG
- Treats bladder pain or discomfort in interstitial cystitis
HOW COMFORA 100MG WORKS
COMFORA 100MG works by strengthening and modifying glycosaminoglycans (a type of complex carbohydrates present in the walls of urinary bladder) which provides relief from painful bladder filling and facilitates proper emptying of bladder thus treating symptoms of interstitial cystitis.
DIRECTIONS FOR USE
Take COMFORA 100MG as advised by your physician. Swallow the capsule with the glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF COMFORA 100MG
COMMON
- hair loss
- diarrhoea
- nausea
- headache
- rash
- indigestion
- abdominal pain
- dizziness
- infections such as common cold
- swelling in ankles and legs
- back pain
- pelvic pain
- frequent urination
- weakness
- enlarged abdomen
- rectal haemorrhage
- symptoms of influenza such as fever or feeling feverish/chills, cough, sore throat, and runny or stuffy nose
UNCOMMON
- vomiting
- mouth ulcer
- signs of inflammation in intestines such as diarrhoea, abdominal pain, or rectal pain
- signs of inflammation in food pipe such as difficult and painful swallowing
- signs of inflammation in stomach such as nausea, vomiting, and abdominal pain
- flatulence
- constipation
- anorexia (eating disorder causing weight loss)
- gum bleeding
- signs of anaemia such as weakness, paleness, and fainting
- ecchymosis (discoloration of skin due to bleeding in underlying tissues)
- prolonged bleeding time
- signs of lack of white blood cells such as increased frequency of infections
- unusual bleeding
- signs of allergic reaction such as rashes, redness, and swelling
- sensitivity to light
- inflammation in throat
- inflammation in nose
- nose bleeding
- shortness of breath
- itching
- raised, red, and itchy bumps on skin
- inflammation in the eyes
- sensation of ringing in ears
- signs of inflammation of an eye nerve (optic nerve) such as vision loss or pain on moving eyes
- amblyopia (reduced vision in one eye)
- bleeding inside the eyes
- severe mood swings or depression
- increased sweating
- sleeplessness
- restlessness
- prickling or tingling sensation in hands and feet
- teary eyes
- increase in the size of moles
- muscle pain
- joint pain
- bleeding beneath the skin
- loss of appetite
- weight loss/gain
RARE
Stop taking COMFORA 100MG and contact your doctor if you experience any of the following side effects:
- signs of changes in the retina of the eye (pigmentary maculopathy) such as vision abnormalities including difficulty while reading, visual distortions, and altered colour vision
- sensitivity to light
- signs of increased bleeding such as easy bruising, nosebleeds, gum bleeding, or blood in stool
HOW TO MANAGE SIDE EFFECTS
Headache:
Take rest and drink plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching screen for long time. Consult your doctor if the condition persists for long period or gets worsened.
Dizziness:
Lie down until the dizziness passes and get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol, or smoking. Consult your doctor if the condition persists for long or gets worsened.
Diarrhoea:
Drink lot of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.
Constipation:
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatments for constipation.
Nausea and Vomiting:
Try to take COMFORA 100MG with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
WARNING & PRECAUTIONS
PREGNANCY
COMFORA 100MG is not recommended for use during pregnancy. Consult your doctor before taking COMFORA 100MG.
BREASTFEEDING
COMFORA 100MG is not recommended for use in breastfeeding women. Consult your doctor before taking COMFORA 100MG.
DRIVING AND USING MACHINES
COMFORA 100MG is unlikely to affect the ability to drive or operate machines. Consult your doctor before taking COMFORA 100MG.
KIDNEY
COMFORA 100MG is used with caution in patients with kidney problems such as reduced kidney function or kidney impairment. Consult your doctor for advice before taking COMFORA 100MG.
LIVER
COMFORA 100MG should be used with caution in patients with liver problems such as reduced liver function or liver impairment. Consult your doctor before taking COMFORA 100MG.
ALLERGY
COMFORA 100MG is not recommended for use if you are allergic to Pentosan polysulphate, or any other ingredients of this medicine.
OTHERS
COMFORA 100MG is not recommended for use if you:
- have bleeding problems (other than menstrual bleeding)
Before taking COMFORA 100MG, inform your doctor if you have:
- any personal or family history of retinal or eye problems
- any history of aneurysms (ballooning at weakened areas in the arteries)
- haemophilia (bleeding disorder causing inability of blood clot formation)
- gastrointestinal tract problems including ulcerations, polyps (small growths), or diverticula (abnormal pouches)
- problems with bleeding (thrombocytopenia)
- scheduled surgery
Use in pediatrics:
COMFORA 100MG is not recommended for use in children and adolescents (below 18 years of age). Consult your doctor before taking. COMFORA 100MG.
Use in geriatrics:
COMFORA 100MG should be used with caution in elderly patients (above 60 years of age). Consult your doctor before taking COMFORA 100MG.
INTERACTIONS
A. Drug-Drug Interaction:
Before taking COMFORA 100MG, inform your doctor, if you are taking any of the following:
- medicines used to prevent blood clotting Ex. warfarin, heparin, streptokinase
- medicines used to treat pain and inflammation Ex. aspirin, ibuprofen
Overdosage:
If you or anyone else accidentally takes too much of COMFORA 100MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are increase bleeding, unusual bleeding, signs of liver function abnormalities (stomach pain, dark urine, or tiredness) or abdominal discomfort.
SYNOPSIS
| Drug | : | Pentosan polysulphate |
| Pharmacological Category | : | Anticoagulant |
| Therapeutic Indication | : | Bladder pain in interstitial cystitis |
| Dosage Forms | : | Capsule |
MORE INFORMATION
- Keep the medicine out of reach in children
- Store COMFORA 100MG at room temperature
FAQs ABOUT COMFORA 100MG
What is COMFORA 100MG used for?
COMFORA 100MG is used to treat bladder pain or discomfort in interstitial cystitis. Interstitial cystitis is a long-standing painful condition in which the bladder wall becomes painful and irritated, generally characterized by symptoms such as bladder pressure/pain, pelvic pain, and/or persistent urgency to urinate.
What happens if you take more COMFORA 100MG than your required dose?
If you or anyone else accidentally takes too much of COMFORA 100MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are increase bleeding, unusual bleeding, signs of liver function abnormalities (stomach pain, dark urine, or tiredness) or abdominal discomfort.
What common side effects are seen with COMFORA 100MG?
The common side effects associated with the use of COMFORA 100MG are hair loss, diarrhoea, nausea, headache, rash, indigestion, abdominal pain, and dizziness. Contact your doctor or visit nearby hospital if any of the symptom worsens.
Who should avoid taking COMFORA 100MG?
COMFORA 100MG is not recommended for use in patients allergic to pentosan polysulphate and in patients suffering from bleeding problems. It is also not recommended for use in pregnant and breastfeeding women, including children and adolescents (below 18 years of age). Consult your doctor before taking it.
Is COMFORA 100MG safe to use in children or elderly patients?
COMFORA 100MG is not recommended for use in children and adolescents (below 18 years of age). It should be used with caution in elderly patients (above 60 years of age). Consult your doctor before taking COMFORA 100MG.
How COMFORA 100MG works?
COMFORA 100MG works by strengthening and modifying glycosaminoglycans (a type of complex carbohydrates present in the walls of urinary bladder) which provides relief from painful bladder filling and facilitates proper emptying of bladder thus treating symptoms of interstitial cystitis.
What if I forget to take COMFORA 100MG dose?
You should take COMFORA 100MG immediately when you remember. If it is time for your next dose skip the missed dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.
When to stop taking COMFORA 100MG?
Stop taking COMFORA 100MG and contact your doctor immediately, if you experience vision abnormalities (which may cause difficulty while reading, visual distortions and altered colour vision), sensitivity to light, and/or increased bleeding (easy bruising, nosebleeds, gum bleeding, or blood in stool).
REFERENCES
1. Robert M. Moldwin. Urological and Gynaecological Chronic Pelvic Pain, Current Therapies. Edition 2017. Page – 243.
2. Andreas Wiedemann. Oral therapy for interstitial cystitis: pentosan polysulfate sodium. NIH National Library of Medicine. National Centre for Biotechnology Information. PubMed.gov. December 2021. [Accessed on 11th July 2022] https://pubmed.ncbi.nlm.nih.gov/34583396/
3. Janssen Pharmaceuticals, Inc. Elmiron-100 Mg Capsules (Pentosan Polysulfate Sodium). [Revised in March 2021] [Accessed on 11th July 2022] https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/ELMIRON-pi.pdf
4. Bene-Arzneimittel GmbH. European Medicines Agency (EMA). [Revised in June 2017] [Accessed on 11th July 2022] https://www.ema.europa.eu/en/documents/product-information/elmiron-epar-product-information_en.pdf
USEFUL DIAGNOSTIC TESTS
- Blood clotting tests
- Liver function test
- Kidney function test
- Eye examination
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