INTRODUCTION
COMBIZOL + SUSPENSION is a combination of Metronidazole and Ofloxacin, which belong to the group of medicines called Antibiotics. COMBIZOL + SUSPENSION is used to treat different kinds of bacterial and parasitic infections (caused by different kinds of bacteria or parasites), diarrhea (loose, watery stools that occur more often than usual) and systemic infection (an infection that is in the bloodstream).
COMBIZOL + SUSPENSION should be used with caution in patients with liver problems, kidney problems and heart disease. COMBIZOL + SUSPENSION is not recommended for use by pregnant or breastfeeding women. Consult your doctor before taking it.
The most common side effects of COMBIZOL + SUSPENSION are nausea, headache, sleeplessness, genital itching in women, dizziness, vaginal inflammation, diarrhoea and vomiting. Consult your doctor if any of the symptoms worsen.
USES OF COMBIZOL + SUSPENSION
- Treats bacterial and parasitic infections
- Treats diarrhea
- Treats systemic infection (an infection that is in the bloodstream)
HOW COMBIZOL + SUSPENSION WORKS
COMBIZOL + SUSPENSION helps to reduce infections caused by different bacteria or parasites, whereas Metronidazole works by inhibiting the protein synthesis in the cells of various bacteria and parasites, which gradually leads to cell death. Ofloxacin works by preventing bacterial growth (DNA replication), which leads to cell death.
DIRECTIONS FOR USE
Always use COMBIZOL + SUSPENSION as directed by your physician. Shake well before use. Do not stop using COMBIZOL + SUSPENSION without informing your doctor.
SIDE EFFECTS OF COMBIZOL + SUSPENSION
COMMON
- nausea
- headache
- sleeplessness
- genital itching in women
- dizziness
- vaginal inflammation
- diarrhoea
- vomiting
RARE
Stop using COMBIZOL + SUSPENSION and contact your doctor immediately if you have:
- allergic reaction with symptoms such as swelling of the face, lips, throat or tongue, itching, difficulty breathing, difficulty swallowing
- skin rashes with blistering, peeling or bleeding of the skin around the lips, eyes, mouth, nose and genitals
- serious but very rare side effect is a brain disease (encephalopathy)
- blistering or bleeding of the skin around the eyes, mouth, lips, nose and genitals
- red, scaly widespread rash with bumps under the skin and blisters accompanied by fever
- steven johnson syndrome - severe blistering rash where layers of the skin may peel off
HOW TO MANAGE SIDE EFFECTS
Nausea / Vomiting:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods. Consult your doctor if the symptom does not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume alcohol. Consult your doctor if the symptom does not improve.
Dizziness:
If you feel dizzy, keep your eyes closed sit or lie down. Do not drive or operate machinery. Consult your doctor if the symptom does not improve.
Diarrhea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhoea. Consult your doctor if the symptom does not improve.
WARNING & PRECAUTIONS
PREGNANCY
COMBIZOL + SUSPENSION is not recommended for use in pregnant women. Consult your doctor before using it.
BREASTFEEDING
COMBIZOL + SUSPENSION is not recommended for use in breastfeeding women. Consult your doctor before using it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel sleepy or dizzy or could affect your eyesight after using COMBIZOL + SUSPENSION. Consult your doctor before using it.
ALCOHOL
Avoid consumption of alcohol while taking COMBIZOL + SUSPENSION because it might cause unpleasant side effects such as nausea, vomiting, hot flushes, stomach pain, very fast or uneven heartbeat and headache. Consult your doctor before using it.
KIDNEY
COMBIZOL + SUSPENSION should be used with caution in patients with kidney problems and patients undergoing kidney dialysis. Consult your doctor before using it.
LIVER
COMBIZOL + SUSPENSION should be used with caution in patients with liver problems. Consult your doctor before using it.
ALLERGY
Do not take COMBIZOL + SUSPENSION if you are allergic to metronidazole, ofloxacin, other quinolone antibiotics such as ciprofloxacin or norfloxacin or any of the other ingredients in this medicine. Consult your doctor before using it.
LUNGS
COMBIZOL + SUSPENSION should be used with caution in patients with a lung transplant. Consult your doctor before using it.
HEART DISEASE
COMBIZOL + SUSPENSION should be used with caution in patients with heart disease. Consult your doctor before using it.
OTHERS
Before using COMBIZOL + SUSPENSION, inform your doctor if you:
- have a disease of the nervous system
- are on hemodialysis
- have a history of joint problems or rheumatoid arthritis
- are suffering from Alzheimer’s disease, seizures, stroke
- have decreased in blood minerals
Use in Pediatrics:
COMBIZOL + SUSPENSION should be used with caution in children. Consult your doctor before using it.
Use in Geriatrics:
COMBIZOL + SUSPENSION should be used with caution. Consult your doctor before using it.
INTERACTIONS
A. Drug-Drug interactions:
Before taking COMBIZOL + SUSPENSION, inform your doctor if you are taking any of these medicines:
- warfarin (anticoagulants)
- lithium (used to treat mental illness)
- phenytoin, carbamazepine, phenobarbitone (used to treat epilepsy)
- 5 fluorouracil, busulfan (used to treat cancer)
- ciclosporin (immunosuppressant)
- disulfiram
Overdosage:
If you or anyone else accidentally receive too much of COMBIZOL + SUSPENSION, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Metronidazole, Ofloxacin |
| Pharmacological Category | : | Nitroimidazole antibiotic, Quinolone antibiotic |
| Therapeutic Indication | : | Bacterial and parasitic infections, diarrhea, systemic infection |
| Dosage Forms | : | Tablet, Syrup, Suspension, Oral Suspension |
MORE INFORMATION
- Keep COMBIZOL + SUSPENSION out of reach from children
- Store at room temperature
FAQs ABOUT COMBIZOL + SUSPENSION
Can I drive after taking COMBIZOL + SUSPENSION?
Do not drive or operate any machines if you feel sleepy or dizzy or if it could affect your eyesight after taking COMBIZOL + SUSPENSION. Since COMBIZOL + SUSPENSION is an antibiotic, it will affect the body’s normal functioning. So, it is advised not to drive or operate any machinery after taking COMBIZOL + SUSPENSION.
Can breast-feeding women take COMBIZOL + SUSPENSION?
A few clinical trial studies show that COMBIZOL + SUSPENSION passes through the breast milk from mother to infant while breastfeeding. So, COMBIZOL + SUSPENSION is not recommended for breastfeeding women. Consult your doctor before taking it.
I am presently undergoing kidney dialysis. Can I take COMBIZOL + SUSPENSION?
COMBIZOL + SUSPENSION should be used with caution in dialysis patients. Since dialysis purifies intoxicants and other materials in the blood, COMBIZOL + SUSPENSION can also be removed. So, the effect of COMBIZOL + SUSPENSION might be reduced. It is better to inform your doctor if you are on dialysis and you are taking COMBIZOL + SUSPENSION.
Does COMBIZOL + SUSPENSION cause vomiting?
Since vomiting is the most common side effect observed for COMBIZOL + SUSPENSION, it may cause vomiting. So, eat simple meals and avoid oily or spicy foods and take this medicine with or just after meals. Consult your doctor if the symptom does not improve.
How many doses of COMBIZOL + SUSPENSION can I take in a day?
Take COMBIZOL + SUSPENSION as advised by your physician. Do not crush or chew the medicine. Swallow the medicine with a glass of water. Your doctor will determine the correct dose and duration for you depending on your age, body weight and disease condition.
Does COMBIZOL + SUSPENSION cause sleeplessness?
Yes, the use of COMBIZOL + SUSPENSION may cause sleeplessness. COMBIZOL + SUSPENSION may influence the normal sleep cycle, resulting in reduced sleep compared to normal. So, it is better to make your surroundings comfortable, which can have a positive influence on sleep (like the room light being dimmed or minimizing external noises).
REFERENCES
1. KD Tripathi, Anti-microbial drugs and Beta-lactam Antibiotics, Essentials of medical pharmacology, Seventh edition. 2013 Page 894 & 713.
2. Connor B. Weir; Jacqueline K. Le., Metronidazole, National Library of Medicine. [Revised April 2022] [Accessed 22 June 2022] https://www.ncbi.nlm.nih.gov/books/NBK539728/
3. JB Chemicals, OFM SUSP, CIMS. [Accessed 22 June 2022] https://www.mims.com/india/drug/info/ofm%20susp
4. Rosemont, Metronidazole. [Revised April 2020] [Accessed 22 June 2022] https://www.medicines.org.uk/emc/files/pil.6690.pdf
5. Medindia, Ofloxacin. [Accessed 22 June 2022] https://www.medindia.net/drug-price/ofloxacin/zo-60ml.htm#Indication
PRODUCT DETAILS
ALTERNATE BRANDS View All
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.