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COENAC 400 Injection 2ml
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INTRODUCTION
COENAC 400 contain Acetylcysteine which belongs to a group of medicine called mucolytic agents. It is used to treat paracetamol overdose (where you may have taken too much paracetamol). It helps to protect the liver from damage by the high levels of paracetamol. It is very effective when given during the first 8 hour following paracetamol overdose. The effectiveness is reduced as the time interval increase, but it can still help when given up to 24 hours after the overdose. It work by increasing the level of glutathione, an antioxidant that neutralises the toxic products of paracetamol.
This medicine must be given by a doctor or nurse. Do not drive or operate machinery while taking this medicine, since it may cause feeling unwell. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
USES OF COENAC 400
- Treat paracetamol overdose
HOW COENAC 400 WORKS
COENAC 400 work by increasing the level of glutathione, an antioxidant that neutralises the toxic products of paracetamol.
DIRECTIONS FOR USE
COENAC 400 given as an intravenous infusion (a drip into a vein) by a doctor or nurse.
SIDE EFFECTS OF COENAC 400
SERIOUS
- swelling of the face, lips, or tongue
- wheezing, difficulty in breathing
- nausea, vomiting
- irritation at the injection site
- skin rash, itching
- flushing (red face or feeling hot)
- low blood pressure resulting in dizziness
- rapid heartbeat or increased blood pressure
RARE
- coughing, noisy breathing
- respiratory arrest (stop breathing)
- chest tightness or pain
- puffy eye, blurred vision, pain in the face or eye
- sweating, feeling unwell
- raised temperature, hot, red face, and skin
- liver problems
- slow heartbeat, cardiac arrest (heart stops beating)
- fainting, collapsing, fits
- reduction in blood platelets, which increases the risk of bleeding or bruising
- acidosis which may cause weariness, vomiting, thirst or restlessness
- anxiety
- joint pain or disease
- bluish skin from low oxygen level in the blood
HOW TO MANAGE SIDE EFFECTS
Nausea and Vomiting:
Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
Skin itching:
Apply a cold, wet cloth, or ice pack on the skin. Moisturize your skin. Apply cooling agents, such as menthol or calamine.
Dizziness:
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
Cough:
Drink fluids which helps thin the mucus in your throat. Suck on cough drops or hard candies.
WARNING & PRECAUTIONS
PREGNANCY
COENAC 400 should be used with caution in pregnant women. Consult your doctor before taking this medicine.
BREASTFEEDING
COENAC 400 should be used with caution in breast feeding women. Consult your doctor before taking this medicine.
DRIVING AND USING MACHINES
Do not drive or operate machinery while taking this medicine, since it may cause feeling unwell.
ALCOHOL
Consumption of alcohol is not recommended during treatment with COENAC 400.
KIDNEY
COENAC 400 should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
COENAC 400 should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take COENAC 400 if you are allergic (hypersensitive) to acetylcysteine or any other ingredients in this medicine.
LUNGS
COENAC 400 should be used with caution in patients suffering from active lung diseases (asthma or breathing difficulties). Consult your doctor for advice.
INTERACTIONS
Tell your doctor about all the medicine you take, including prescription and non-prescription medicine, vitamins, and herbal supplements.
SYNOPSIS
| Drug | : | Acetylcysteine |
| Pharmacological Category | : | Antidote, Mucolytic Agent |
| Therapeutic Indication | : | Paracetamol overdose |
| Dosage Forms | : | Effervescent Tablet, Tablet, Capsule, Powder, Injection, Syrup |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT COENAC 400
How does COENAC 400 work?
It work by increasing the level of glutathione, an antioxidant that neutralises the toxic products of paracetamol.
Can COENAC 400 cause skin itching?
Yes, this medicine may cause skin itching in some individuals. Apply a cold, wet cloth, or ice pack on the skin. Moisturize your skin. Apply cooling agents, such as menthol or calamine.
How do you take COENAC 400?
This medicine given as an intravenous infusion (a drip into a vein) by a doctor or nurse.
REFERENCES
1. KD Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of Medical Pharmacology. seventh edition.2013. Page - 219.
2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 65-68.
3. Kennon J. Heard, M.D. Acetylcysteine for Acetaminophen Poisoning.US National Library of Medicines, National Institutes of Health. 17 Jul 2008. [Accessed 07 Nov 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637612/
4. Panpharma GmbH; Electronic Medicines Compendium (EMC); [Revised on Dec 2019] [Accessed 07 Nov 2020] https://www.medicines.org.uk/emc/files/pil.3447.pdf
PRODUCT DETAILS
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