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INTRODUCTION
CO MUPIMET GRANULES is a combination of Mupirocin and Metronidazole which belongs to the group of medicines called Antibiotics. It helps to treat chronic wounds and prevents the bacterial infections. It is also helps to treat chronic tunnel wounds, bed sores and diabetic foot ulcers.
Bacterial skin infections develop when bacteria enter through hair follicles, small breaks in the skin that result from scrapes, punctures, surgery, burns, sunburn, animal or insect bites, wounds and pre-existing skin disorders.
Before applying CO MUPIMET GRANULES inform your doctor if you have kidney, liver, nervous system problems, bleeding disorder, open wounds or damaged skin.
Before applying CO MUPIMET GRANULES inform your doctor if you are pregnant or breastfeeding women.
CO MUPIMET GRANULES should be used with caution in children and elderly patients. The most common side effects of applying CO MUPIMET GRANULES are burning sensation, itching, redness, irritation at the application site. Consult your doctor if the above side effects does not improve.
USES OF CO MUPIMET GRANULES
It is used to:
- treat chronic wounds, bed sores and diabetic foot ulcers
- prevent bacterial infections
HOW CO MUPIMET GRANULES WORKS
CO MUPIMET GRANULES works against the bacteria and promoting faster healing of the infection in which mupirocin exerts its action by reversibly binding to an enzyme (isoleucyl transfer RNA synthetase) and inhibits its activity of synthesis of proteins in the bacteria and produce microbicidal action. Metronidazole destroys the bacteria and other microorganisms that cause infections by damaging the DNA.
DIRECTIONS FOR USE
Use CO MUPIMET GRANULES as advised by your physician. It is for external use only. Clean the wound bed with sterile saline and sprinkle the medicine directly to the affected area. Your doctor will decide the right dose and duration depending upon your age, body weight and disease condition.
SIDE EFFECTS OF CO MUPIMET GRANULES
COMMON
- burning, irritation, itching and redness (at application site)
UNCOMMON
- allergic rash, redness or soreness of the skin on the face, hands or body
RARE
Stop applying CO MUPIMET GRANULES and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reaction which may include a red and lumpy skin rash, difficulty breathing, swelling of face, mouth, lips or eyelids, unexplained high temperature (fever), difficulty breathing and swallowing and feeling faint
- inflammation of the colon (larger intestine), causing diarrhea, usually with blood and mucus, stomach pain, fever (pseudomembranous colitis)
WARNING & PRECAUTIONS
PREGNANCY
Safety and effectiveness of CO MUPIMET GRANULES in pregnant women has not been established yet, it should be used with caution in pregnant women or if planning to have a baby. Consult your doctor before applying it.
BREASTFEEDING
CO MUPIMET GRANULES should be used with caution in breastfeeding women. Consult your doctor before applying it.
DRIVING AND USING MACHINES
CO MUPIMET GRANULES is unlikely to affect your ability to drive or use machines. Consult your doctor before applying it.
KIDNEY
CO MUPIMET GRANULES should be used with caution in patients with kidney problems. Consult your doctor before applying.
LIVER
CO MUPIMET GRANULES should be used with caution in patients with liver problems. Consult your doctor before applying.
ALLERGY
Do not apply CO MUPIMET GRANULES if you are allergic to Mupirocin, Metronidazole or any other ingredients of this medicine.
OTHERS
CO MUPIMET GRANULES is not recommended for use if you:
- have bleeding disorders
- have central nervous system disorder
Before applying CO MUPIMET GRANULES, inform your doctor if you:
- have open wounds or damaged skin
Use in Pediatrics:
CO MUPIMET GRANULES should be used with caution in children above 2 months of age. Consult your doctor before applying.
Use in Geriatrics:
CO MUPIMET GRANULES should be used with caution in elderly patients above 65 years of age as they are more sensitive to the side effects. Consult your doctor before applying.
INTERACTIONS
A. Drug - Drug interactions:
Before applying CO MUPIMET GRANULES, inform your doctor if you are taking any of the following medicine:
- medicines used to treat alcoholism (Ex. disulfiram)
- medicines used to treat HIV/AIDS infection (Ex. lopinavir, ritonavir)
- antidepressants (Ex. lithium)
- blood thinner (Ex. warfarin)
- fits medicine (Ex. phenytoin, phenobarbital)
- immunosuppressants (Ex. ciclosporin)
- anticancer medicines (Ex. fluorouracil, busulfan)
Overdosage:
If you or anyone else accidentally applies too much of CO MUPIMET GRANULES, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are severe allergic skin reactions.
SYNOPSIS
| Drug | : | Mupirocin, Metronidazole |
| Pharmacological Category | : | Anti-bacterial agents |
| Therapeutic Indication | : | Bacterial skin infections |
| Dosage Forms | : | Ointment, Cream, Granules |
MORE INFORMATION
- Keep CO MUPIMET GRANULES out of reach of children
- Store at room temperature
FAQs ABOUT CO MUPIMET GRANULES
Q: What is CO MUPIMET GRANULES used for?
A: CO MUPIMET GRANULES helps to treat chronic wounds and prevents the bacterial infections. It is also helps to treat chronic tunnel wounds, bed sores and diabetic foot ulcers.
Q: Can CO MUPIMET GRANULES cause any side effects?
A: The most common side effects of applying CO MUPIMET GRANULES are burning sensation, itching, redness, irritation at the application site. Consult your doctor if symptoms does not improve.
Q: How to apply CO MUPIMET GRANULES?
A: Use CO MUPIMET GRANULES as advised by your physician. It is for external use only. Clean the wound bed with sterile saline and sprinkle the medicine directly to the affected area. Your doctor will decide the right dose and duration depending upon your age, body weight and disease condition.
Q: Can CO MUPIMET GRANULES be used in pregnant women?
A: Safety and effectiveness of CO MUPIMET GRANULES in pregnant women has not been established yet, hence it should be used with caution in pregnant women or if planning to have a baby. Consult your doctor before applying it.
Q: What precaution need to be taken while using CO MUPIMET GRANULES?
A: CO MUPIMET GRANULES is not recommended for use in patients with hypersensitivity, bleeding disorders and nervous system problems. Consult your doctor before using.
REFERENCES
1. KD Tripathi. Antiamoebic and Other Antiprotozoal Drugs. Essentials of medical pharmacology. Eight Edition. 2019. Page – 894-897.
2. Connor B. Weir; Jacqueline K. Le. Metronidazole. [Revised on April 2022] [Accessed on 7th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK539728/#:~:text=Go%20to%3A-,Mechanism%20of%20Action,cell%20death%20in%20susceptible%20organisms.
3. Wingfield E. Rehmus. Overview of Bacterial Skin Infections. [Revised on April 2021] [Accessed on 7th June 2022] https://www.msdmanuals.com/en-in/home/skin-disorders/bacterial-skin-infections/overview-of-bacterial-skin-infections
4. Tejraj P. Kale, S.M.Kotrashetti, Sidramesh Muttagi, Anuj Kumar. Use of Co Mupimet as a Local Therapeutic Agent for Extensive Infected Lacerated Wound: A Case Report of few Cases and Extensive Review of Management. [Accessed on 7th June 2022] https://www.researchgate.net/publication/291519312_Use_of_Co_Mupimet_as_a_Local_Therapeutic_Agent_for_Extensive_Infected_Lacerated_Wound_A_Case_Report_of_few_Cases_and_Extensive_Review_of_Management
5. Kleva Pharmaceuticals. S.A. Electronic Medicines Compendium (EMC). [Revised in March 2018] [Accessed on 7th June 2022] https://www.medicines.org.uk/emc/files/pil.3365.pdf
6. Mupirocin + Metronidazole. Medicine India. [Accessed on 7th June 2022] https://www.medicineindia.org/pharmacology-for-generic/3369/mupirocin-metronidazole
7. Mupirocin + Metronidazole. Mayoclinic. [Revised in September 2021] [Accessed on 7th June 2022] https://www.mayoclinic.org/diseases-conditions/rosacea/symptoms-causes/syc-20353815
8. Fourrts pharmaceuticals. [Accessed on 7th June 2022] http://www.fourrts.com/comupimet/
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