INTRODUCTION

CLOTRISURE CREAM contains Clotrimazole which belongs to the group of medicines called Antifungals. It is used in the treatment of fungal skin infections such as ringworm (fungal infection of the skin or scalp), athlete’s foot (fungal infection between the toes), fungal nappy rash (skin rash affecting the nappy area) and fungal sweat rash. It also relieves irritation of the vulva (external thrush) or at the end of the penis, which may be associated with thrush.

Before applying CLOTRISURE CREAM inform your doctor about your previous existing disease conditions. CLOTRISURE CREAM is not recommended for use in patients who are allergic to clotrimazole. Avoid smoking or going near flames and wearing fabrics that catch fire easily due to the increased risk of severe burns.

CLOTRISURE CREAM can be used in pregnant and breastfeeding women. Avoid using latex contraceptives (condoms or diaphragms) as this medicine may reduce the effectiveness of such contraceptives, use alternative precautions for at least five days after using the medicine. Consult your doctor immediately if you experience any unusual effects.

USES OF CLOTRISURE CREAM

• Treats fungal skin infections (such as ringworm, athlete’s foots, fungal nappy rash and sweat rash)
• Relieves irritation of the vulva or at the end of the penis (which may be associated with thrush)

HOW CLOTRISURE CREAM WORKS

CLOTRISURE CREAM acts by specifically inhibiting the biosynthesis of ergosterol and other sterols (enzymes) required for cell membrane production, therefore it inhibits the division and growth of fungi eventually leading to cell death, which further prevents fungal growth.

DIRECTIONS FOR USE

Always apply CLOTRISURE CREAM as directed by your physician. It is for external use only. Clean and dry the affected surface before applying the medicine. Apply and rub gently a thin layer of this medicine on the affected area. Wash your hands before and after applying the medicine. Do not use CLOTRISURE CREAM on your face, eyes, or large area. Do not use under bandages or for a long time without consulting your doctor. Your doctor will decide the duration and time interval for application depending on the type of infection.

SIDE EFFECTS OF CLOTRISURE CREAM

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before applying CLOTRISURE CREAM, inform your doctor if you have recently taken or take any other medicines including non-prescription medicines and using:

• latex contraceptives (such as condoms or diaphragms) used to prevent pregnancy

Overdosage:

There is no risk of acute intoxication of topical administration. If you or anyone else accidentally ingest CLOTRISURE CREAM, consult your doctor immediately or visit the nearby hospital. Symptoms include dizziness, nausea or vomiting.

SYNOPSIS

MORE INFORMATION

• Keep CLOTRISURE CREAM out of reach from children
• Store at room temperature

FAQs ABOUT CLOTRISURE CREAM

Q: What is CLOTRISURE CREAM used for?

A: CLOTRISURE CREAM is used in the treatment of fungal skin infections such as ringworm (fungal infection of the skin or scalp), athlete’s foot (fungal infection between the toes), fungal nappy rash (skin rash affecting the nappy area) and fungal sweat rash. It also relieves irritation of the vulva (external thrush) or at the end of the penis, which may be associated with thrush. 

Q: How does CLOTRISURE CREAM work?

A: CLOTRISURE CREAM acts by specifically inhibiting the biosynthesis of ergosterol and other sterols (enzymes) required for cell membrane production, therefore it inhibits the division and growth of fungi eventually leading to cell death, which further prevents fungal growth. 

Q: What are the side effects of CLOTRISURE CREAM?

A: The side effects that can be associated with the use of CLOTRISURE CREAM are itching, rash, blisters, burning, discomfort, swelling, irritation, tingling or prickling sensation, redness and peeling of the skin. Consult your doctor immediately if any of the side effects get worse

Q: Can CLOTRISURE CREAM be used in children?

A: No, the safety and effectiveness of CLOTRISURE CREAM are not established in children. Consult the child’s doctor to select a suitable alternative therapy for your child depending upon the type of infection.

Q: Does CLOTRISURE CREAM cause an allergic reaction?

A: CLOTRISURE CREAM may cause allergic reactions rarely in some individuals. Signs include rash, swelling of the lips, throat, tongue or face, feeling faint or dizzy, weakness, nausea and swallowing or breathing problems. If you experience this effect, consult your doctor immediately.

REFERENCES

1. K. D. Tripathi, Antimicrobial Drugs Essentials of pharmacology seventh edition 2013 page no- 792

2. Dan Zhao, Bing Chen, Ying-Ting Wang, Chuan-Hua Jiao. Topical clotrimazole cream for the treatment of tinea cruris. NIH. National Library of Medicine, National center for biotechnology information. Pubmed Central. November 2020 [Accessed on 12th August 2022]  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676513/

3. P R Sawyer, R N Brogden, R M Pinder, T M Speight, Avery. Clotrimazole: a review of its antifungal activity and therapeutic efficacy. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 1975. [Accessed on 12th August 2022] https://pubmed.ncbi.nlm.nih.gov/1097234/

4. Mylan UK Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 12th August 2022] https://www.medicines.org.uk/emc/files/pil.2598.pdf

5. Glenmark Pharmaceuticals Ltd. DailyMed; National Library of Medicine. National Institute of Health. [Revised in September 2014] [Accessed on 12th August 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f6898117-14f3-42d2-bc0e-d296add3ad70&type=display

6. Palsons Derma. Kanel-DS Gel/Lotion (clotrimazole) [Accessed on 12th August 2022] https://www.palsonsderma.com/kansel-ds-gel-ds-lotion

7. Albatross pharma. (Clotrimazole 1, 2% topical gel) [Accessed on 12th August 2022] http://www.albatrosspharma.com/PDFs/canitross-DS.pdf