INTRODUCTION

CLOTIVAC EAR DROPS is a combination of Beclomethasone, Clotrimazole, Lignocaine and Neomycin which belongs to the group of medicines called Corticosteroids, Antifungals, Local anesthetic agents and Antibiotics respectively. It is used to treat ear infections like otitis externa and chronic suppurative otitis media.

Otitis externa is a condition that causes inflammation (redness and swelling) of the external ear canal, which is the tube between the outer ear and eardrum. Chronic suppurative otitis media is a type of ear disease where there is an ongoing chronic infection of the middle ear without an intact tympanic membrane.

CLOTIVAC EAR DROPS is not recommended for use in patients with psychiatric illnesses, epilepsy and severe systemic infections. Contact your doctor before using. CLOTIVAC EAR DROPS should be used with caution in patients with lung, liver, kidney or heart diseases. Contact your doctor before using. CLOTIVAC EAR DROPS should be used with caution in pregnancy and breastfeeding women.

CLOTIVAC EAR DROPS is not recommended for use in children. Contact your doctor before using in children. Safety and effectiveness of CLOTIVAC EAR DROPS in geriatric patients have not been established. Contact your doctor before using. The most common side effects of this medicine are mild irritation, burning or stinging sensation in the ear. Contact your physician if any of the above symptoms worsen.

USES OF CLOTIVAC EAR DROPS

• Used to treat mixed ear infections like otitis externa and chronic suppurative otitis media

HOW CLOTIVAC EAR DROPS WORKS

CLOTIVAC EAR DROPS helps to treat infection, where Beclomethasone belongs to corticosteroid which blocks the production of certain chemical messengers which are responsible for pain, inflammation and allergy, Clotrimazole is an antifungal which stops the growth of fungi, while Lignocaine is an anaesthetic that blocks the sensation of pain and Neomycin is an antibiotic which inhibits the bacterial growth in the ear.

DIRECTIONS FOR USE

Use CLOTIVAC EAR DROPS as advised by the physician. Instill the medicine in the affected ear with a dropper as directed by your physician. It is for external use only. Your doctor will prescribe the right dose depends on your age, body weight and severity of infection.

SIDE EFFECTS OF CLOTIVAC EAR DROPS

WARNING & PRECAUTIONS

PREGNANCY

Use with Caution

CLOTIVAC EAR DROPS should be used with caution in pregnant women. Contact your doctor before using.

BREASTFEEDING

Use with Caution

CLOTIVAC EAR DROPS should be used with caution in breastfeeding women. Contact your doctor before using.

DRIVING AND USING MACHINES

Use with Caution

Be cautious while driving or operating machines until the response to CLOTIVAC EAR DROPS is known.

KIDNEY

Use with Caution

CLOTIVAC EAR DROPS should be used with caution in patients with kidney failure. Contact your doctor before using.

LIVER

Use with Caution

CLOTIVAC EAR DROPS should be used with caution in patients with liver disease. Contact your doctor before using.

ALLERGY

Contraindicated

Do not use CLOTIVAC EAR DROPS if you are allergic to Beclomethasone, Clotrimazole, Lignocaine and Neomycin or to any other ingredients of this medicine.

USE IN PEDIATRICS

Contraindicated

CLOTIVAC EAR DROPS is not recommended for use in children. Contact your doctor before using the medicine.

USE IN GERIATRICS

Consult your doctor

Safety and effectiveness of CLOTIVAC EAR DROPS in geriatric patients have not been established. Contact your doctor before using.

INTERACTIONS

A. Drug-Drug interactions:

Tell your doctor if you are using or have recently taken any other medicines, including medicines obtained without a prescription, vitamin supplement or herbal products.

Overdosage:

If you or anyone else accidentally uses too much of CLOTIVAC EAR DROPS, consult your doctor immediately or visit the nearby hospital. In all cases of overdosage, start general symptomatic and supportive measures.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Store CLOTIVAC EAR DROPS below 30°C

FAQs ABOUT CLOTIVAC EAR DROPS

Q: What are the side effects of using CLOTIVAC EAR DROPS?

A: The most common side effects of this medicine are mild irritation, burning or stinging sensation in the ear. Contact your physician if any of the symptoms worsen.

Q: Can I stop using CLOTIVAC EAR DROPS when my symptoms are relieved?

A: Do not stop using CLOTIVAC EAR DROPS on your own, even if the symptoms are relieved until the course advised by the doctor is finished.

Q: Who should not use CLOTIVAC EAR DROPS?

A: CLOTIVAC EAR DROPS is not recommended for use in patients with psychiatric illnesses, epilepsy and severe systemic infections, children and elderly patients. Contact your doctor before using.

Q: How to use CLOTIVAC EAR DROPS?

A: Instil CLOTIVAC EAR DROPS in affected ear with dropper as directed by your physician. It is for external use only. Your doctor will prescribe the right dose depends on your age, body weight and severity of infection.

REFERENCES

1. K.D. Tripathi. Corticosteroids, Antifungal drugs, Local Anaesthetics & Aminoglycoside Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 294,792,366, 750.

2. Bethesda (MD). Beclomethasone Dipropionate. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 30th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/21700

3. Bethesda (MD). Clotrimazole. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 30th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/2812

4. Bethesda (MD). Lignocaine. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 30th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/3676

5. Bethesda (MD). Neomycin sulphate. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 30th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/8378

6. Mayuresh Kiran, Shruthi George, Lalit Pawaskar. Uses of Beclomethasone dipropionate + Clotrimazole + Lignocaine +Neomycin sulphate. Research gate Journals. June 2017. [Accessed on 30th June 2022] https://www.researchgate.net/publication/331222914_Safety_and_Efficacy_of_a_topical_combination_of_Neomycin_Clotrimazole_Beclomethasone_and_Lignocaine_for_management_of_Ear_Infections_Phase_IV_Study

7. Able Pharma. Otiflox Ear drops (Beclomethasone dipropionate + Clotrimazole + Lignocaine +Neomycin sulphate). [Revised in January 2021] [Accessed on 30th June 2022] https://www.centaurpharma.com/downloads/2021/entchestphysician/anti-infectives/Otiflox%20new%20ear%20drops.pdf