INTRODUCTION

CLOFIRST 75MG contains Clopidogrel which belongs to a group of medicines called antiplatelet which prevents the clumping and reduces the formation of blood clots (thrombosis). Platelets are very small structures in the blood which clump together during blood clotting. This medicine is used to prevent blood clots in conditions such as atherosclerosis, where the arteries are hardened, unstable angina or heart attack and irregular heartbeat.

It works by preventing platelets from clumping together and forming clots. It binds irreversibly to the P2Y12 class of adenosine diphosphate (ADP) receptors on platelets and inhibits their clumping. This prevents the formation of blood clots and thus lowers the risk of heart attack or stroke. Before taking this medicine inform your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding.

CLOFIRST 75MG is not suitable for use in children. Your doctor will give the correct dose depends on your age, body weight and health condition. The most common side effects is bleeding. Do not take if you had bleeding disorder or have stomach ulcer or bleeding within the brain.

USES OF CLOFIRST 75MG

• Prevent blood clots in conditions such as atherosclerosis, unstable angina or myocardial infarction (heart attack) and atrial fibrillation (irregular heartbeat)

HOW CLOFIRST 75MG WORKS

Clopidogrel works by preventing platelets from clumping together and forming clots and lowers heart attack or stroke.

DIRECTIONS FOR USE

Always take CLOFIRST 75MG as instructed by your doctor. Swallow as a whole and do not crush or chew. Do not exceed the recommended dose. Your doctor will give the right dose depends on your condition. It may be taken with or without food.

SIDE EFFECTS OF CLOFIRST 75MG

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• heparin, ticlopidine and oral anticoagulants (used to reduce blood clotting)
• non-steroidal anti-inflammatory medicine (treat painful and inflammatory conditions of muscle or joints)
• fluoxetine, moclobemide and fluvoxamine (treat depression)
• omeprazole, esomeprazole (treat upset stomach)
• fluconazole, voriconazole (treat fungal infections)
• efavirenz (treats HIV infections)
• carbamazepine (treats epilepsy)
• repaglinide (used to treat diabetes)
• paclitaxel (used to treat cancer)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT CLOFIRST 75MG

How long can I take CLOFIRST 75MG for?

Take this medicine as prescribed by your doctor. Do not stop the treatment suddenly or take for a longer period than recommended by your doctor.

What does CLOFIRST 75MG do to your body?

It slows the blood's clotting action by making platelets less sticky and reduces the risk of heart attack or stroke.  

REFERENCES

1. KD Tripathi MD. Drugs affecting blood and blood formation. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page - 630.

2. Weitz JI. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 869-870.

3. Zehnder JL. Drugs Used in Disorders of Coagulation. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 598-599.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 304-305.

5. Fox KA, White HD, Gersh BJ, et al. Antithrombotic Agents: Platelet Inhibitors, Acute Anticoagulants, Fibrinolytics, and Chronic Anticoagulants. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. Page - 245-248.

6. Xi-Ling Jiang, Snehal Samant, Lawrence J. Lesko, and Stephan Schmidt. Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel. Feb 2015. [Accessed on March 27, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677184/

7. Torrent pharmaceuticals Ltd. Sep 09, 2013. [Revised on July, 2019] [Accessed on March 27, 2021] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1884.pdf

8. Sanofi-aventis groupe. Electronic Medicines Compendium (EMC); [Revised on Jan 2021] [Accessed on March 27, 2021] https://www.medicines.org.uk/emc/files/pil.5934.pd