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INTRODUCTION
CLINOL 300 INJECTION contains Clindamycin, which belongs to the group of medicines called Antibiotics. It is used to treat serious bacterial infections in adults and adolescents above 12 years of age. Bacterial infection occurs when bacteria enter the body, increasing in number and causing a reaction in the body. Symptoms include fever, fatigue, headache, nausea, vomiting and swollen lymph nodes in the neck, armpits, groin or elsewhere.
Before receiving CLINOL 300 INJECTION, inform your doctor if you have or ever had impaired kidney and liver function, gastrointestinal diseases (colon inflammation) or problems with muscle function (Parkinson’s disease, myasthenia gravis). CLINOL 300 INJECTION should be used with caution in pregnant and breastfeeding women, consult your doctor before receiving.
CLINOL 300 INJECTION is generally not recommended for use in children below 12 years of age. CLINOL 300 INJECTION should be used with caution in elderly patients above 60 years of age. The most common side effects of receiving CLINOL 300 INJECTION are nausea, abdominal pain, vomiting, diarrhea, blood abnormalities and skin rashes. Consult your doctor if your symptoms do not improve.
USES OF CLINOL 300 INJECTION
- Treats serious bacterial infections in adults and adolescents (over 12 years of age)
HOW CLINOL 300 INJECTION WORKS
CLINOL 300 INJECTION acts against the bacteria by binding to the 50S subunit of the bacterial ribosome (site of protein synthesis). Which in turn prevents protein synthesis and kills the infection-causing bacteria.
DIRECTIONS FOR USE
CLINOL 300 INJECTION will be administered to you only by a doctor or a nurse into your vein (intravenous infusion with a drip). Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF CLINOL 300 INJECTION
COMMON
- gastrointestinal disorders (nausea, abdominal pain, vomiting, diarrhea)
- severe or prolonged or bloody diarrhea during or after treatment may be a sign of bowel inflammation (pseudomembranous colitis)
- blood abnormalities (changes in the number of white blood cells or reduction in blood platelets (which increases the risk of bleeding or bruising))
- diseases of the blood vessels such as inflammation of the veins(thrombophlebitis).
- skin lesions with large blistering skin rash (maculopapular exanthema, morbilliform exanthema), ’nettle rash’ (urticaria)
- the results of liver tests may be affected
UNCOMMON
- nervous system disturbances, such as an inhibiting nerve impulse progression (neuromuscular blocking effect) and altered taste (dysgeusia)
- difficulty breathing, low blood pressure
- pain and abscess at the site of injection
RARE
- fever
- itchy skin (pruritus).
- inflammation of the vaginal mucosa (vaginitis)
- serious skin reactions:
- Stevens-Johnson syndrome (peeling of large areas of skin, especially around the mouth, nose, eyes, and genitals) and Lyell syndrome (a more serious illness with blistering of the skin)
- extensive red skin rash with skin flaking (exfoliative dermatitis, bullous dermatitis, erythema multiforme)
- serious allergic reaction which causes swelling of the face or throat(angioedema)
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if symptoms do not show improvement.
Diarrhea:
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Consult your doctor if symptoms do not show improvement.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have smaller meals. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.
WARNING & PRECAUTIONS
PREGNANCY
CLINOL 300 INJECTION should be used with caution in pregnant women or women planning to have a baby. It will be given to you by the doctor only if it's clearly necessary. Consult your doctor before receiving it.
BREASTFEEDING
CLINOL 300 INJECTION should be used with caution in breastfeeding women as it can pass into breast milk. The breastfed infant can have diarrhea, fungal infections, and hypersensitivity. Consult your doctor before receiving it.
DRIVING AND USING MACHINES
Do not drive or use machines as CLINOL 300 INJECTION may cause mild to moderate side effects like feeling dizzy, tired or headaches. Consult your doctor for advice.
KIDNEY
CLINOL 300 INJECTION should be used with caution in patients with impaired kidney problems. Consult your doctor before receiving it.
LIVER
CLINOL 300 INJECTION should be used with caution in patients with impaired liver problems. Consult your doctor before receiving it.
ALLERGY
Do not receive CLINOL 300 INJECTION if you are allergic to Clindamycin or any other ingredients of this medicine.
OTHERS
Before receiving CLINOL 300 INJECTION, inform your doctor if you:
- have problems with your muscle functions (Ex. myasthenia gravis (pathological muscular weakness) or Parkinson’s disease (shaking palsy)
- have previously suffered from gastrointestinal diseases (Ex. inflammation of the colon)
Use in pediatrics:
CLINOL 300 INJECTION is not recommended for use in children below 12 years of age. Consult your doctor before receiving CLINOL 300 INJECTION.
Use in geriatrics:
CLINOL 300 INJECTION should be used with caution in elderly patients above 60 years of age. consult your doctor before receiving CLINOL 300 INJECTION.
INTERACTIONS
A. Drug-Drug interactions:
Before receiving CLINOL 300 INJECTION, inform your doctor if you are taking any of the following medicine:
- warfarin or similar medicines (Ex. acenocoumarol and fluindione) used to thin the blood.
- muscle relaxants (Ex. cyclobenzaprine)
- rifampicin (to treat tuberculosis)
- St John's wort (Hypericum perforatum) to treat depression
- carbamazepine, phenytoin or phenobarbital (to treat epilepsy)
- enzalutamide (treats prostate cancer), dabrafenib (cancer drug)
- efavirenz (treats HIV/AIDS)
Overdosage:
CLINOL 300 INJECTION will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
SYNOPSIS
| Drug | : | Clindamycin |
| Pharmacological Category | : | Lincosamides |
| Therapeutic Indication | : | Serious bacterial infections |
| Dosage Forms | : | Injection, Tablet, Capsule, Gel, Cream, Lotion, Solution, Spray, Soap |
MORE INFORMATION
- Keep CLINOL 300 INJECTION out of reach of children
- Do not store above 25°C
FAQs ABOUT CLINOL 300 INJECTION
What is CLINOL 300 INJECTION used for?
CLINOL 300 INJECTION is used to treat serious bacterial infections in adults and adolescents above 12 years of age. Bacterial infection occurs when bacteria enter the body, increasing in number and causing a reaction in the body. Symptoms include fever, fatigue, headache, nausea, vomiting and swollen lymph nodes in the neck, armpits, groin or elsewhere.
Can I drive while receiving CLINOL 300 INJECTION?
Do not drive or use machines as CLINOL 300 INJECTION may cause mild to moderate side effects like feeling dizzy, tiredness or headaches. Consult your doctor for advice.
How does CLINOL 300 INJECTION work?
CLINOL 300 INJECTION acts against the bacteria by binding to the 50S subunit of the bacterial ribosome (site of protein synthesis). Which in turn prevents protein synthesis and kills the infection-causing bacteria.
Can CLINOL 300 INJECTION be used in pregnancy?
CLINOL 300 INJECTION should be used with caution in pregnant women or women planning to have a baby. It will be given to you by the doctor only if it's clearly necessary. Consult your doctor before receiving it.
Can CLINOL 300 INJECTION be used in children?
CLINOL 300 INJECTION is not recommended for use in children below 12 years of age. Consult your doctor before receiving it for more information on safety measures.
REFERENCES
1. KD Tripathi. Macrolide, Lincosamide, Glycopeptide and Other Anti bacteria IN Antibiotics. Urinary Antiseptics. Essentials of Medical Pharmacology. Eighth Edition. 2019. Page –805-806.
2. Patrick B, Murphy, Karlyle G. Bistas, Jacqueline K.Le. Clindamycin. National Library of medicine, National center for biotechnology information.[Revised in July 2021] [Accessed on 11th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK519574/
3. Manuel Polanco Morales, Anna Paola Thome Carvallo, Karla Adriana Bautista Espinosa,and Edgar Enrique Meza Murillo. A young man with myelosuppression caused by clindamycin: a case report. National Library of medicine, National center for biotechnology information. Pubmed central 2014. [Accessed on 11th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917410/
4. Infomed Fluids Srl. Electronic Medicines Compendium (EMC). [Revised in March 2019] [Accessed on 11th May 2022] https://www.medicines.org.uk/emc/files/pil.11006.pdf
5. Pfizer. Pharmacia & Upjohn Co. U.S Food and Drug Administration. [Revised in October 2013] [Accessed on 11th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/050441s079,050639s038lbl.pdf
6. Clindamycin. Healthdirect. [Revised in August 2020] [Accessed on 11th May 2022] https://www.healthdirect.gov.au/bacterial-infections
USEFUL DIAGNOSTIC TESTS
- Complete blood count test
- Liver function test
- Kidney function test
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