INTRODUCTION

CLINBIOTIC SOFTGEL SUPPOSITORIES is a combination of Clindamycin, Clotrimazole, and Tinidazole which belongs to the group of medicines called Antibiotics, Antifungals, and Antiprotozoals respectively. It is used to treat vaginal infections caused by fungus alone or secondarily infected with bacteria.

Fungal vaginal infections often involve both the vulva and the vagina, with symptoms like intense vulvar itching, soreness, irritation, burning while urinating, pain, redness, curdy cheese like discharge, small injuries, and swelling.

Before using CLINBIOTIC SOFTGEL SUPPOSITORIES, inform your doctor if you have any problems with formation of blood clots or fits. Consult your doctor for advice.

CLINBIOTIC SOFTGEL SUPPOSITORIES is not recommended for use in first trimester of pregnancy and should be used with caution in rest of the pregnancy, and in breastfeeding women. Consult your doctor for advice before using.

The most common side effects of using CLINBIOTIC SOFTGEL SUPPOSITORIES are loss of appetite, bitter taste, nausea, vomiting, diarrhea, extreme tiredness, dry mouth, stomach distress, and headache. Contact your doctor if any of above the side effects worsen.

USES OF CLINBIOTIC SOFTGEL SUPPOSITORIES

• Used to treat vaginal infections

HOW CLINBIOTIC SOFTGEL SUPPOSITORIES WORKS

CLINBIOTIC SOFTGEL SUPPOSITORIES works by stopping the growth of infecting fungus where Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit and directly preventing the formation of bacterial protein. Clotrimazole inhibits the synthesis of a substance (ergosterol), which is an integral part of the cell membrane, thus impairing the fungal cell membrane, and Tinidazole releases certain unstable molecules (free radicals) during cell metabolism that bind to DNA, damage it, and results in cell death.

DIRECTIONS FOR USE

Use CLINBIOTIC SOFTGEL SUPPOSITORIES as advised by your physician. It is for vaginal use only. Check the label for directions before use. Wash and dry your vaginal area and lie on your back and gently insert the medicine into the vagina as high as possible with or without the use of an applicator as mentioned in the label. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of infection.

SIDE EFFECTS OF CLINBIOTIC SOFTGEL SUPPOSITORIES

HOW TO MANAGE SIDE EFFECTS

Nausea or Vomiting:

Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to simple meals. Avoid eating oily or spicy foods. Get adequate rest. Drink lots of fluids, especially water. Do not take any medicine for nausea or vomiting without asking the doctor.  

Headache:

Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Ask your doctor before taking any medicine for headache. If headache does not improve, contact your doctor.

Diarrhoea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If diarrhea does not improve, contact your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before using CLINBIOTIC SOFTGEL SUPPOSITORIES, inform your doctor if you are using, have used, or might use any other medicine, including prescription, non-prescription or any herbal medicine.

Overdosage:

If you or anyone else accidentally uses too much of CLINBIOTIC SOFTGEL SUPPOSITORIES, contact your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep CLINBIOTIC SOFTGEL SUPPOSITORIES out of reach of children
• Store below 30°C

FAQs ABOUT CLINBIOTIC SOFTGEL SUPPOSITORIES

Q: What if I forget to use a dose of CLINBIOTIC SOFTGEL SUPPOSITORIES?

A: If you forget to use a dose of CLINBIOTIC SOFTGEL SUPPOSITORIES, use it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not use CLINBIOTIC SOFTGEL SUPPOSITORIES twice to make up for a forgotten dose. If you have any more doubts regarding the use of CLINBIOTIC SOFTGEL SUPPOSITORIES, ask your doctor.

Q: Does CLINBIOTIC SOFTGEL SUPPOSITORIES cause vomiting?

A: Vomiting is a common side effect of CLINBIOTIC SOFTGEL SUPPOSITORIES. In such cases, get adequate rest and drink lots of fluids, especially water. Have small sips if you feel sick. Do not take any medicine for vomiting without asking your doctor. Tell your doctor if you have continuous vomiting.

Q: What precautions do I need to follow while using CLINBIOTIC SOFTGEL SUPPOSITORIES?

A: Patients using CLINBIOTIC SOFTGEL SUPPOSITORIES must inform their doctor about their pre-existing disease conditions like blood cell formation problems, low neutrophil count, or fits. Contact your doctor immediately if you have any unusual symptoms.

Q: Can CLINBIOTIC SOFTGEL SUPPOSITORIES be used in pregnancy?

A: CLINBIOTIC SOFTGEL SUPPOSITORIES is not recommended for use in first trimester of pregnancy. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before using CLINBIOTIC SOFTGEL SUPPOSITORIES. Inform your doctor immediately if you become pregnant during treatment with CLINBIOTIC SOFTGEL SUPPOSITORIES.

Q: Does CLINBIOTIC SOFTGEL SUPPOSITORIES cause headache?

A: Headache is a common side effect of CLINBIOTIC SOFTGEL SUPPOSITORIES. In such case, drink ample amount of water and get adequate rest. Try to be relaxed and stress free. Ask your doctor before taking any medicine for headache. If symptom does not improve, contact your doctor.

REFERENCES

1. Joseph T. DiPiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. Wells, L. Michael Posey. Superficial Fungal Infections. Pharmacotherapy- A Pathophysiologic Approach. Eighth edition. Page-2056.

2. M. Maladkar, C. Tekchandani, U. Dave. Clindamycin, Clotrimazole and Tinidazole in Mixed Vaginosis- A “Real World” Clinical Experience. Journal of Gynecology and Obstetrics. January 2015. [Accessed on 24th June 2022] https://www.researchgate.net/publication/284617556_Clindamycin_Clotrimazole_and_Tinidazole_in_Mixed_Vaginosis-A_Real_World_Clinical_Experience

3. DM Pharma. Clindamycin + Clotrimazole +Tinidazole. [Accessed on 24th June 2022] https://www.dmpharma.co.in/Clindamycin%20Phosphate,%20Clotrimazole%20and%20Tinidazole%20Soft%20Gelatin%20Capsules.html

USEFUL DIAGNOSTIC TESTS

• Pelvic exam