INTRODUCTION

CLIN contains Clindamycin which belongs to the group of medicines called antibiotics. It fights against bacteria and used in the treatment of severe bacterial infections. Clindamycin acts by inhibiting bacterial protein synthesis which stops bacterial growth and prevents further spread of infection. It is not suitable for the treatment of brain infections because it cannot pass through your brain.

It can be taken either before or after a meal. Depending upon your age and health condition, your doctor will decide a suitable dose for you. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results. Patients receiving this medicine for a very long time should regularly undergo blood tests and/or liver and kidney functioning. Long-term use of this medicine may also cause certain other infections resistant to clindamycin. In such cases, please inform your doctor.

The most common side effects of this medicine are diarrhea, stomach pain, nausea and vomiting. Contact your doctor if any of the symptom bothers you. However, if you experience severe persistent bloody diarrhea following treatment with CLIN, contact your doctor immediately, as it could be a sign of bowel inflammation (pseudomembranous colitis). Before taking this medicine, inform your doctor if you have any serious kidney or liver disease. Proper dose adjustments and regular monitoring of amount of clindamycin in blood are required in such patients. It should be used with caution in pregnant women and in children. Consult your doctor before taking. It is not recommended for use in lactating mothers, because it may pass into breast milk.

USES OF CLIN

• Treats severe bacterial infections

HOW CLIN WORKS

Clindamycin acts by reversibly binding to the 50S ribosomal subunits of the bacteria, which prevents peptide bond formation thus inhibiting bacterial protein synthesis. Inhibition of protein synthesis stops bacterial growth and prevents further spread of infection.

DIRECTIONS FOR USE

Take CLIN as directed by your physician. It can be taken either before or after a meal. Swallow the medicine as whole with a sip of water. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your age, body weight and health condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF CLIN

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after meals. Stick to simple meals. Do not eat rich or spicy food.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor, if you are taking:

• erythromycin (an antibiotic used to treat infections)
• muscle relaxants used for operations (e.g. baclofen, dantrolene, diazepam)
• warfarin or similar medicines (used to thin your blood)
• rifampicin (used to treat tuberculosis)
• St. John’s Wort (used to treat depression)
• phenytoin (used to treat epilepsy)
• carbamazepine (used to treat epilepsy or nerve pain)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT CLIN

Can CLIN cause diarrhea?

Yes. It may cause diarrhea in some individuals. Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor. However, if you experience severe persistent bloody diarrhea following treatment with this medicine, contact your doctor immediately, as it could be a sign of bowel inflammation (pseudomembranous colitis).

Can CLIN be ineffective?

While taking this medicine, it is important to inform your doctor if you do not feel better or if you feel worse. Long-term use of this medicine may also cause certain other infections resistant to clindamycin. Based upon the outcomes, your doctor might decide a suitable dose or alternate therapy for you.

Can CLIN cause stomach pain?

Yes. It may cause stomach pain in some individuals. Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keep a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

REFERENCES

1. KD. Tripathi. Macrolide, Lincosamide, Glycopeptide and Other Antibacterial Antibiotics; Urinary Antiseptics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 756-757.

2. Conan MacDougall and Henry F. Chambers. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1534-1535.

3. Gerald G. Briggs and Roger K. Freeman. C. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 856-857.

4. Teva Pharmaceuticals USA. Clindamycin 300 mg Capsules in Healthy Subjects Under Fasting Conditions. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on September 2009] [Accessed 9th December 2020]. https://clinicaltrials.gov/ct2/show/NCT00836056

5. Marek Smieja. Current indications for the use of clindamycin: A critical review. NCBI; PMC US National Library of Medicine, National Institute of Health. January-February 1998. [Accessed 9th December 2020]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250868/

6. Balkanpharma-Razgrad AD. Electronic Medicines Compendium (EMC); [Revised on January 2016] [Accessed 9th December 2020] https://www.medicines.org.uk/emc/files/pil.7337.pdf

7. Chanelle Medical. Electronic Medicines Compendium (EMC); [Revised on September 2020] [Accessed 9th December 2020] https://www.medicines.org.uk/emc/files/pil.10202.pdf

8. Balkanpharma-Dupnitsa AD and Balkanpharma – Razgrad AD. Health Products Regulatory Authority (HPRA). [Revised on October 2017] [Accessed 9th December 2020] http://www.hpra.ie/img/uploaded/swedocuments/PIL-2198972-08022018172614-636537075764375000.pdf

USEFUL DIAGNOSTIC TESTS

• Complete Blood Count
• Peripheral Smear Examination