INTRODUCTION

CIPREMI RTU 100 INJECTION contains Remdesivir which belongs to the group of medicines called Antiviral drugs. It is used in adults and children (older than 28 days and weighing at least 3 kg) for the treatment of coronavirus disease 2019 (COVID-19) who have pneumonia, need extra oxygen to help them breathe, but who are not on artificial ventilation.

It also treats adults and children (weighing at least 40 kg) who do not need extra oxygen to breathe and are at increased risk for progressing to severe COVID-19. Coronavirus causes short-term, mild upper respiratory infection (common cold), with symptoms like nasal obstruction, sneezing, runny nose, and sometimes cough.

Prior to the treatment, your doctor may want you to take several blood tests to understand your existing condition. Before receiving CIPREMI RTU 100 INJECTION, inform your doctor if you have any liver, kidney problems, or if you are immunocompromised.

CIPREMI RTU 100 INJECTION should be used with caution among pregnant or breastfeeding women, therefore consult your doctor before receiving. CIPREMI RTU 100 INJECTION is not recommended for children younger than 28 days of age or weighing less than 3 kg.

CIPREMI RTU 100 INJECTION should be used with caution in elderly patients above 65 years of age. The most common side effects of receiving CIPREMI RTU 100 INJECTION are nausea, headache, or rash. Contact your doctor if any of the symptoms worsen.

USES OF CIPREMI RTU 100 INJECTION

• It is used in adults and children (older than 28 days and weighing at least 3 kg) for the treatment of coronavirus disease 2019 (COVID-19)
• It also treats adults and children (weighing at least 40 kg) who do not need extra oxygen to breathe and are at increased risk for progressing to severe COVID-19

HOW CIPREMI RTU 100 INJECTION WORKS

CIPREMI RTU 100 INJECTION stops the viral RNA (converts information in DNA to proteins) synthesis which in turn works by stopping the virus multiplication in cells and even the virus multiplication in the body. Thus, helping your body to overcome the virus infection.

DIRECTIONS FOR USE

CIPREMI RTU 100 INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF CIPREMI RTU 100 INJECTION

HOW TO MANAGE SIDE EFFECTS

Nausea:

Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if symptoms do not improve.

Headache:

Drink an ample amount of water. Get adequate rest. Try to be relaxed and stress-free. Ask your doctor before taking any medicine for headaches. Avoid bright lights. Consult your doctor if symptoms do not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before receiving CIPREMI RTU 100 INJECTION, inform your doctor if you are taking any of the following medicine:

• chloroquine phosphate (used to treat and prevent malaria)
• hydroxychloroquine sulfate (used to treat joint inflammation)
• midazolam (used to induce sleep)
• pitavastatin (used to reduce blood cholesterol)
• theophylline (used to treat symptoms of asthma, bronchitis, or other lung diseases)
• rifampicin (used to treat infections like tuberculosis)

Overdosage:

CIPREMI RTU 100 INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so you are unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

SYNOPSIS

MORE INFORMATION

• Keep CIPREMI RTU 100 INJECTION out of reach of children
• Store at 30°C

FAQs ABOUT CIPREMI RTU 100 INJECTION

What is CIPREMI RTU 100 INJECTION used for?

CIPREMI RTU 100 INJECTION is used in adults and children (older than 28 days and weighing at least 3 kg) for the treatment of coronavirus disease 2019 (COVID-19) who have pneumonia, need extra oxygen to help them breathe, but who are not on artificial ventilation. It also treats adults and children (weighing at least 40 kg) who do not need extra oxygen to help them breathe and are at increased risk for progressing to severe COVID-19.

Do I need to take any tests while receiving CIPREMI RTU 100 INJECTION?

Yes. You will be given blood tests before and during treatment with CIPREMI RTU 100 INJECTION as determined by your doctor. These tests are to check for kidney or liver problems, and the time taken by your blood to clot.

Is CIPREMI RTU 100 INJECTION safe in pregnancy?

CIPREMI RTU 100 INJECTION should be received with caution in pregnant women or women planning to have a baby as it is not known if it can harm your unborn baby. It will only be given if the potential benefits of treatment outweigh the potential risks to the mother and the unborn child. You must use effective contraception during this treatment. Consult your doctor before receiving it.

How does CIPREMI RTU 100 INJECTION work?

CIPREMI RTU 100 INJECTION stops the viral RNA (converts information in DNA to proteins) synthesis which in turn works by stopping the virus multiplication in cells and even the virus multiplication in the body. Thus, helping your body to overcome the virus infection.

Can CIPREMI RTU 100 INJECTION cause a headache?

Yes. Headache is a common side effect of CIPREMI RTU 100 INJECTION. In such cases, drink ample amount of water and get adequate rest. Try to be relaxed and stress-free. Avoid bright lights. Ask your doctor before taking any medicine for headaches.

REFERENCES

1. KD Tripathi. Drugs for cough and bronchial asthma. Essentials of Medical Pharmacology. 8th edition. 2019. Page – 237.

2. Richard T. Eastman, Jacob S. Roth, Kyle R. Brimacombe, Anton Simeonov, Min Shen, Samarjit Patnaik, and Matthew D. Hall. Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19. NIH, National library of medicine, National center for biotechnology information. Pubmed Central. May 2020. [Accessed on 1st June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202249/

3. Abdul Aleem, Jiten P. Kothadia. Remdesivir. NIH, National library of medicine, National center for biotechnology information. Pubmed.gov. September 2022. [Accessed on 1st June 2022] https://pubmed.ncbi.nlm.nih.gov/33085408/

4. Gilead Sciences Ireland UC. Electronic Medicines Compendium (EMC). [Revised in September 2022] [Accessed on 1st June 2022] https://www.medicines.org.uk/emc/files/pil.11597.pdf

5. Gilead Sciences, Inc. U.S. Food & Drug Administration. [Revised in October 2020] [Accessed on 1st June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/214787Orig1s000lbl.pdf

USEFUL DIAGNOSTIC TESTS

• RT-PCR test
• Antigen test