Cilodoc 100mg Tablet 10'S

INTRODUCTION

CILODOC 100MG TABLET contains Cilostazol which belongs to the group of medicines called Phosphodiesterase type 3 inhibitors. It is used in the treatment of intermittent claudication, which is defined as the cramp-like pain in the legs while walking caused by insufficient blood supply in the legs. Symptoms include pain, ache, discomfort or fatigue in muscles every time, when those muscles are used (usually the calves, thighs, buttocks, hips or feet).

Along with this treatment your doctor might advise you to make lifestyle modifications like increasing regular exercise and stop smoking. Prior to the treatment, your doctor may want you to take ankle-brachial index test to understand your existing condition.

CILODOC 100MG TABLET is not recommended for use in patients having severe heart problems (such as heart failure, heart attack), uncontrolled blood pressure, kidney or liver disease, active stomach ulcer and stroke.

Do not drink large amounts of grapefruit juice while taking CILODOC 100MG TABLET as it may reduce the effect of this medicine. CILODOC 100MG TABLET is not recommended for use among pregnant or breastfeeding women, therefore consult your doctor before taking it. This medicine is not recommended for use in children and adolescents.

The most common side effects of taking CILODOC 100MG TABLET are headache, abnormal stools, diarrhea, abdominal discomfort, dizziness, nausea and loss of appetite.  Consult your doctor if any of the side effects worsen over the time.

USES OF CILODOC 100MG TABLET

• Treats intermittent claudication

HOW CILODOC 100MG TABLET WORKS

CILODOC 100MG TABLET acts by inhibiting the activity of certain enzymes (phosphodiesterase) which helps in the increase in the level of cAMP (cellular messengers to initiate certain actions) in platelets and blood vessels. The cAMP helps in widening of some blood vessels and reducing the clotting activity of platelets inside the blood vessels. Hence increasing the blood circulation to the legs making it easier and less painful to walk.

DIRECTIONS FOR USE

Take CILODOC 100MG TABLET as advised by your physician. Swallow CILODOC 100MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF CILODOC 100MG TABLET

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom does not improve. 

Dizziness Or Drowsiness

Lie down until dizziness goes away and then move slowly and carefully. Take sufficient rest and drink plenty of fluids. Rise slowly after sitting or lying down. Be careful while going up and down stairs. Consult your doctor if the symptom worsens.

Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve. 

Nausea And Vomiting

Stick to simple meals while taking this medicine. Avoid eating oily, fried and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom does not improve.

Stomach Pain

Try to rest and relax. Eat and drink slowly or try to eat smaller meals more frequently. Keep a heat pad on your stomach. Consult your doctor if the symptom does not improve.  

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

CILODOC 100MG TABLET is not recommended for use in pregnant women. Consult your doctor before taking CILODOC 100MG TABLET.

BREASTFEEDING

Contraindicated

CILODOC 100MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking CILODOC 100MG TABLET.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate heavy machines if you experience dizziness while taking CILODOC 100MG TABLET.

KIDNEY

Contraindicated

CILODOC 100MG TABLET is not recommended for use in patients with severe kidney disease. Consult your doctor before taking CILODOC 100MG TABLET.

LIVER

Contraindicated

CILODOC 100MG TABLET is not recommended for use in patients with moderate or severe liver disease. Consult your doctor before taking CILODOC 100MG TABLET.

ALLERGY

Contraindicated

Do not take CILODOC 100MG TABLET if you are allergic to Cilostazol or any other ingredients of this medicine.

HEART DISEASE

Consult your doctor

CILODOC 100MG TABLET is not recommended for use in patients with heart failure, had heart attack, persistent chest pain at rest, any heart surgery in the last 6 months, suffered from blackouts due to heart disease or any severe disturbances of the heartbeat. It should be taken with caution in patients with severe heart problem or any other problems with your heart beat and high blood pressure. Consult your doctor before taking CILODOC 100MG TABLET.

INTERACTIONS

A. Drug-Drug interactions:

Before taking CILODOC 100MG TABLET, inform your doctor if you are taking any of the following medicines:

• acetylsalicylic acid (aspirin) (used to treat painful inflammatory condition of muscle or joints)
• anticoagulant medicines (Ex. heparin, warfarin, clopidogrel, dabigatran, rivaroxaban, apixaban) (used to prevent or treat blood clots)
• certain antibiotics Ex. erythromycin, clarithromycin or rifampicin (used to treat bacterial infections)
• ketoconazole (used to treat fungal infections)
• omeprazole (used to treat acidity in the stomach)
• diltiazem (used to treat high blood pressure or chest pain)
• cisapride (used to treat stomach disorders)
• medicines used to treat high cholesterol in the blood (Ex. lovastatin, simvastatin)
• halofantrine (used to treat malaria)
• protease inhibitors such as atazanavir, darunavir (used to treat HIV infection)
• pimozide (used to treat mental illnesses)
• ergot derivatives Ex. ergotamine, dihydroergotamine (used to prevent or treat migraine headaches)
• st. john’s wort (herbal remedy), carbamazepine or phenytoin (used to treat convulsions)
• diuretics Ex. hydrochlorothiazide, furosemide (used to treat fluid retention)
• calcium channel blockers such as verapamil, amlodipine, angiotensin-converting-enzyme inhibitors such as captopril, lisinopril, angiotensin II receptor blockers such as valsartan, candesartan and beta blockers such as labetalol, carvedilol (used to treat high blood pressure)

B. Drug-Food interactions:

Do not drink large amounts of grapefruit juice while taking CILODOC 100MG TABLET as it may reduce the effect of this medicine and do not take together with meals as it may affects its absorption and increase the risk of side effects.

Overdosage:

If you or anyone else accidentally take too much of CILODOC 100MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of CILODOC 100MG TABLET includes severe headache, diarrhea, increase in heart rate and irregularities of the heartbeat.

SYNOPSIS

MORE INFORMATION

• Keep CILODOC 100MG TABLET out of reach of children
• Store CILODOC 100MG TABLET at room temperature

FAQs ABOUT CILODOC 100MG TABLET

Q: How does CILODOC 100MG TABLET work?

A: CILODOC 100MG TABLET acts by inhibiting the activity of certain enzymes (phosphodiesterase) which helps in the increase in the level of cAMP (cellular messengers to initiate certain actions) in platelets and blood vessels. The cAMP helps in widening of some blood vessels and reducing the clotting activity of platelets inside the blood vessels. Hence increasing the blood circulation to the legs making it easier and less painful to walk.

Q: What is CILODOC 100MG TABLET used for?

A: CILODOC 100MG TABLET is used in the treatment of intermittent claudication, which is defined as the cramp-like pain in the legs while walking caused by insufficient blood supply in the legs. Symptoms include pain, ache, discomfort or fatigue in muscles every time, when those muscles are used (usually the calves, thighs, buttocks, hips or feet).

Q: Can I stop taking CILODOC 100MG TABLET on my own?

A: If you stop taking CILODOC 100MG TABLET the pain in your legs may come back or get worse. Therefore, you should only stop taking it if you notice side effects requiring urgent medical attention or if your doctor tells you to.  

Q: What to do If I forget to take a dose of CILODOC 100MG TABLET?

A: You should take CILODOC 100MG TABLET immediately when you remember. If it is time for the next dose skip the missed dose and follow the regular dose schedule. Do not double the dose to match up the missed dose.

Q: Can CILODOC 100MG TABLET be used in pregnant or breast-feeding women?

A: CILODOC 100MG TABLET is not recommended for use in pregnant and breast-feeding women. Consult your doctor before taking this medicine if you are pregnant, planning to become pregnant or breast-feeding your child.  

REFERENCES

1. K.D.Tripathi, Antianginal and Other Anti-ischemic Drugs. Essentials of Medical Pharmacology. Eighth Edition.2019. Page – 601, 602.

2. Alexander M. Balinski; Charles V. Preuss. Cilostazol. NIH National Library of Medicine, National center for biotechnology information. [Revised in September 2021] [Accessed on 3rd May 2022] https://www.ncbi.nlm.nih.gov/books/NBK544363/

3. Tamara Brown, Rachel B Forster, Marcus Cleanthis, Dimitri P Mikhailidis, Gerard Stansby, Marlene Stewart. Cilostazol for intermittent claudication. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. June 2001. [Accessed on 3rd May 2022] https://pubmed.ncbi.nlm.nih.gov/34192807/#:~:text=Authors'%20conclusions%3A%20Cilostazol%20has%20been,higher%20odds%20of%20experiencing%20headache.

4. Adamed Pharma S.A. Electronic Medicines Compendium (EMC). [Revised in February 2020] [Accessed on 3rd May 2022] https://www.medicines.org.uk/emc/files/pil.2590.pdf 

USEFUL DIAGNOSTIC TESTS

• Ankle-brachial index test

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 27 Jan 2023 | 05:43 PM(IST)